<Tr> <Th> Medication </Th> <Td> Albendazole with ivermectin or diethylcarbamazine </Td> </Tr> <Tr> <Th> Frequency </Th> <Td> 38.5 million (2015) </Td> </Tr> <P> Lymphatic filariasis, also known as elephantiasis, is a human disease caused by parasitic worms known as filarial worms . Most cases of the disease have no symptoms . Some people, however, develop a syndrome called elephantiasis, which is marked by severe swelling in the arms, legs, breasts, or genitals . The skin may become thicker as well, and the condition may become painful . The changes to the body may harm the affected person's social and economic situation . </P> <P> The worms are spread by the bites of infected mosquitoes . Three types of worms are known to cause the disease: Wuchereria bancrofti, Brugia malayi, and Brugia timori, with Wuchereria bancrofti being the most common . These worms damage the lymphatic system . The disease is diagnosed by microscopic examination of blood collected during the night . The blood is typically examined as a smear after being stained with Giemsa stain . Testing the blood for antibodies against the disease may also permit diagnosis . Other roundworms from the same family are responsible for river blindness . </P>

What happens when filarial worms infect the lymphatic system
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