<Li> 1935--Hugh Davson and James Danielli proposed that lipid membranes are layers composed by proteins and lipids with pore - like structures that allow specific permeability for certain molecules . Then, they suggested a model for the cell membrane, consisting of a lipid layer surrounded by protein layers at both sides of it . </Li> <Li> 1957--J. David Robertson, based on electron microscopy studies, establishes the "Unit Membrane Hypothesis". This, states that all membranes in the cell, i.e. plasma and organelle membranes, have the same structure: a bilayer of phospholipids with monolayers of proteins at both sides of it . </Li> <Li> 1972--SJ Singer and GL Nicolson proposed the fluid mosaic model as an explanation for the data and latest evidence regarding the structure and thermodynamics of cell membranes . </Li> <Ol> <Li> ^ Jump up to: Nicolson GL (2014). "The Fluid--Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years". Biochimica et Biophysica Acta. 1838 (6): 1451--146 . PMID 24189436 . doi: 10.1016 / j. bbamem. 2013.10. 019 . </Li> <Li> ^ Jump up to: Singer SJ, Nicolson GL (Feb 1972). "The fluid mosaic model of the structure of cell membranes". Science . 175 (4023): 720--31 . PMID 4333397 . doi: 10.1126 / science. 175.4023. 720 . </Li> <Li> Jump up ^ Frye LD, Edidin M (1970). "The rapid intermixing of cell surface antigens after formation of mouse - human heterokaryons". J Cell Sci. 7 (2): 319--35 . PMID 4098863 . </Li> <Li> Jump up ^ Silvius JR (2005). "Partitioning of membrane molecules between raft and non-raft domains: Insights from model - membrane studies". Biochimica et Biophysica Acta. 1746 (3): 193--202 . PMID 16271405 . doi: 10.1016 / j. bbamcr. 2005.09. 003 . </Li> <Li> Jump up ^ Mouritsen OG, Bloom M (1984). "Mattress model of lipid - protein interactions in membranes". Biophys J. 46 (2): 141--153 . PMC 1435039 . PMID 6478029 . doi: 10.1016 / S0006 - 3495 (84) 84007 - 2 . </Li> <Li> Jump up ^ Daleke DL (2003). "Regulation of transbilayer plasma membrane phospholipid asymmetry". J Lipid Res. 44 (2): 233--242 . PMID 12576505 . doi: 10.1194 / jlr. R200019 - JLR200 . </Li> <Li> Jump up ^ Fadok, VA; et al. (1998). "The role of phosphatidylserine in recognition of apoptotic cells by phagocytes". Cell Death and Differ. 5 (7): 551--562 . PMID 10200509 . doi: 10.1038 / sj. cdd. 4400404 . </Li> <Li> Jump up ^ van den Brink - van der Laan E; et al. (2004). "Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile". Biochim Biophys Acta. 1666 (1--2): 275--88 . PMID 15519321 . doi: 10.1016 / j. bbamem. 2004.06. 010 . </Li> <Li> Jump up ^ Frost A; et al. (2009). "The BAR domain superfamily: membrane - molding macromolecules". Cell. 137 (2): 191--6 . PMID 19379681 . doi: 10.1016 / j. cell. 2009.04. 010 . </Li> <Li> Jump up ^ Rodríguez - García R; et al. (2009). "Bimodal spectrum for the curvature fluctuations of bilayer vesicles: pure bending plus hybrid curvature - dilation modes". Phys Rev Lett. 102 (12): 128101 . PMID 19392326 . doi: 10.1103 / PhysRevLett. 102.128101 . </Li> <Li> ^ Jump up to: Alberts B, Johnson A, Lewis J, et al. (2008). Molecular Biology of the Cell (5th ed .). New York: Garland Science . pp. 621--622 . ISBN 978 - 0 - 8153 - 4105 - 5 . </Li> <Li> Jump up ^ Lingwood D, Simons K (2010). "Lipid rafts as a membrane - organizing principle". Science . 327 (5961): 46--50 . PMID 20044567 . doi: 10.1126 / science. 1174621 . </Li> <Li> Jump up ^ G. Vereb; et al. (2003). "Dynamic, yet structured: The cell membrane three decades after the Singer--Nicolson model". PNAS. 100 (14): 8053--8058 . PMC 166180 . PMID 12832616 . doi: 10.1073 / pnas. 1332550100 . </Li> <Li> Jump up ^ Juha Saarikangas; Yves Barral (2011). "The emerging functions of septins in metazoans". EMBO Reports . 12 (11): 1118--1126 . PMC 3207108 . PMID 21997296 . doi: 10.1038 / embor. 2011.193 . </Li> <Li> Jump up ^ Overton, E (1895). "Uberdie osmotischen Eigenshafter der Lebenden Pflanzen und tierzelle". Vjschr Naturf Ges Zurich . 40: 159--201 . </Li> <Li> Jump up ^ E. Gorter; F. Grendel (1925). "On Biomolecular Layers of Lipoids on the Chromocytes of the Blood". Journal of Experimental Medicine . 41: 439--443 . PMC 2130960 . PMID 19868999 . doi: 10.1084 / jem. 41.4. 439 . </Li> <Li> Jump up ^ James Danielli; Hugh Davson (1935). "A contribution to the theory of permeability of thin films". Journal of Cellular and Comparative Physiology. 5 (4): 495--508 . doi: 10.1002 / jcp. 1030050409 . </Li> <Li> Jump up ^ John E. Heuser (1995). "In Memory of J. David Robertson" (PDF). Newsletter of the American Society of Cell Biology . </Li> </Ol>

Why is the model of a membrane referred to as the fluid mosaic model