<P> The animated parts of Osmosis Jones were praised for their plot and fast pace, in contrast with the criticized live action segments . Robert Koehler of Variety praised the film for its animated and live - action segments intervening, claiming it to be "the most extensive interplay of live action and animation since Who Framed Roger Rabbit". The New York Times wrote "the film, with its effluvia - festival brand of humor, is often fun, and the rounded, blobby rendering of the characters is likable . But the picture tries too hard to be offensive to all ages . I suspect that even the littlest viewers will be too old for that spit ." Roger Ebert gave the film 3 stars out of 4 . </P> <P> The use of crude humor in the film, as seen in most films directed by the Farrelly brothers, was widely criticized . As such, Lisa Alspector of the Chicago Reader described the film as a "cathartically disgusting adventure movie". Maitland McDonagh of TV Guide praised the film's animation and its glimpse of intelligence although did criticize the humor as being "so distasteful". Lisa Schwarzbaum of Entertainment Weekly felt that the film had a diverse premise as it "oscillates between streaky black comedy and sanitary instruction", however the scatological themes were again pointed out . Jonathan Foreman of New York Post claimed Osmosis Jones to have generic plotting, saying that "It's no funnier than your average grade - school biology lesson and less pedagogically useful than your typical Farrelly brothers comedy ." Chris Hewitt of Miami Times described Chris Rock's, Brandy Norwood's and Laurence Fishburne's voice work as Osmosis, Leah and Thrax respectively as "classy" although considered the film to be politically correct as all three of these actors are African - American . Michael Sragow of Baltimore Sun praised David Hyde Pierce's performance as Drix, claiming him to be "hilarious" and "a take - charge dose of medicine". Despite of the mixed reviews, the film received numerous Annie award nominations including Best Animated Feature (losing to Shrek). </P> <P> A soundtrack containing hip hop and R&B music was released on August 7, 2001 by Atlantic Records . The soundtrack failed to make it to the Billboard charts, but Trick Daddy's single "Take It to da House" managed to make it to 88 on the Billboard Hot 100 singles chart . </P>

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