<P> Toby Loobenfield (DJ Qualls) is a scientist at CalTech whom Sheldon hires to play his fictional drug - addicted cousin Leo . </P> <P> Dr. Oliver Lorvis (Billy Bob Thornton) is a medical doctor to whom Penny sells products . He misreads her flirtations and locks the guys in his basement while he goes to woo her (as well as Amy and Bernadette). </P> <P> Meemaw / Constance (June Squibb) is Sheldon's grandmother from Texas . She takes an immediate dislike to Amy upon meeting her . It appears she came to visit her grandson, but the real reason she came was to size Amy up and she dislikes Amy because of her breaking Sheldon's heart when she broke up with him . Meemaw keeps this to herself until dinner where she reveals this in front of her grandson, his girlfriend and the married Hofstadter couple . Later, Sheldon reasons with her about how she made her husband (Sheldon's maternal grandfather) a better person when he was stubborn and egotistical and Meemaw soon gives her blessings to Sheldon and Amy's relationship . </P> <P> Octavia (Octavia Spencer) is a DMV worker . </P>

The big bang theory actors in real life