<Tr> <Th> Time zone </Th> <Td> Eastern: UTC − 5 / − 4 </Td> </Tr> <Tr> <Th> Website </Th> <Td> www.greenvillecounty.org </Td> </Tr> <P> Greenville County is a county located in the state of South Carolina, in the United States . As of the 2010 census, the population was 451,225, making it the most populous county in the state . In 2017, the estimated population of the county was 506,837 . Its county seat is Greenville . The county is also home to the Greenville County School District, the largest school system in South Carolina . County government is headquartered at Greenville County Square . </P> <P> Greenville County is included in the Greenville - Anderson - Mauldin, SC Metropolitan Statistical Area . </P>

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