<P> During gluconeogenesis mitochondrial oxaloacetate is reduced to malate which is then transported out of the mitochondrion, to be oxidized back to oxaloacetate in the cytosol . Cytosolic oxaloacetate is then decarboxylated to phosphoenolpyruvate by phosphoenolpyruvate carboxykinase, which is the rate limiting step in the conversion of nearly all the gluconeogenic precursors (such as the glucogenic amino acids and lactate) into glucose by the liver and kidney . </P> <P> Because the citric acid cycle is involved in both catabolic and anabolic processes, it is known as an amphibolic pathway . </P> <P> Click on genes, proteins and metabolites below to link to respective articles . </P> <Ol> <Li> Jump up ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". </Li> </Ol>

The net yield from acetyl-coa in one round of the citric acid cycle