<P> Evidence is insufficient to determine whether or not hyperbaric oxygen therapy as an adjunctive treatment can assist in tissue salvage . Cases have been reported, but no randomized control trial has been performed on humans . </P> <P> Medical sympathectomy using intravenous reserpine has also been attempted with limited success . Studies have suggested that administration of tissue plasminogen activator (tPa) either intravenously or intra-arterially may decrease the likelihood of eventual need for amputation . </P>

Which condition results in the formation of frost