<P> Anna Devane is a fictional character from the original ABC Daytime soap opera, General Hospital, played by Finola Hughes . Hughes also appeared as Anna on All My Children, and the General Hospital prime time, spin - off series, General Hospital: Night Shift . The character first appeared on the April 10, 1985 episode of General Hospital as a fence . The character was created and introduced by executive producer, Gloria Monty, and co-head writers, Pat Falken Smith and Norma Monty . Upon her introduction, Anna is revealed to be the super spy ex-wife of Robert Scorpio and romantic rival to his current wife, Holly Sutton . Anna remained a prominent character in the series until 1992 due to her romantic pairings with Robert and former mobster, Duke Lavery . The storyline in which Duke tries to evade his criminal past with the Jerome family, allows for Duke and Anna to become one of the show's supercouples, along with Robert and Anna . However, the storyline ends in tragedy when Duke dies in Anna's arms . Robert and Anna eventually reunite to raise their daughter, Robin, and eventually remarry; the happiness is short lived and the duo are killed off in 1992 along with their rival, Cesar Faison . </P> <P> However, all three were eventually revealed to be alive . Anna reappeared on All My Children as the twin sister of Dr. Alex Devane on March 2, 2001 . In addition working as chief of police, and a brief romance with Edmund Grey, Anna marries Dr. David Hayward and they had a child together; however, that child dies as an infant . Hughes returned to General Hospital for several guest stints between 2006 and 2008 . Throughout the summer and fall of 2008, Anna appeared on Night Shift where she supported Robert through his battle with cancer and helped Robin prepare for motherhood . Anna returned to the series indefinitely in 2012 when Robin is presumed dead . She has a romance with Robert's best friend, Luke Spencer, and reunites with Duke, whom Faison is masquerading as . Fortunately, the real Duke is revealed to be alive . Anna has become one of the most respected and celebrated heroines in all of daytime . </P> <P> Hughes joined the cast of General Hospital in the spring of 1985, and made her first appearance on April 10, 1985 . Hughes auditioned for the role of Anna in early 1985, about three months after she relocated to New York City . About two weeks later, Hughes was shocked when she actually got hired because the role was originally written for an American actress . In late 1991, rumors circulated that Hughes had been fired . However, instead during contract negotiations, she took advantage of an out clause to work on another project . Hughes last taped scenes aired during December 16, last airing on December 17, 1991 . If negotiations went well, Hughes was slated to return by the spring of 1992 . In the interim, she was replaced by Camilla Moore who made her first appearance December 20, 1991 . Moore last appeared on January 20, 1992 and Hughes returned to the role for one episode on February 25, 1992 . Hughes briefly returned from November 13 to 22, 1995 as Anna's spirit to comfort the character's daughter Robin Scorpio (Kimberly McCullough), who is dealing with the loss of her boyfriend to AIDS - related illness and is herself HIV - positive . On All My Children, when Hughes reprised the role of Alex in February 2001 after her maternity leave, Hughes also made her first appearance as Anna on March 2, 2001 . </P> <P> In late July 2003, All My Children announced that Hughes would exit in the role of Anna when her contract expired . Hughes made her final appearance on September 11, 2003 . An ABC spokesperson hinted that Hughes could return to the series in a recurring capacity but she never did . Rumors immediately followed that Hughes would return to GH . However, Hughes later revealed in an interview that she was open to a return, but had not been contacted by the series . When Tristan Rogers returned to the series as Robert in 2006, many speculated that Hughes would return to the series as well . However instead, Emma Samms instead returned to the series . Samms and Rogers's returns intensified speculation that Hughes would eventually reprise her role, Though initial reports hinted that Hughes refused to return, ABC finally confirmed Hughes's return in April 2006 . Hughes first reappeared May 12, 2006 . Hughes concluded her stint on August 30, and returned once again from July 13 to August 24, 2007 . </P>

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