<Li> High fever (39 ° C; 102 ° F) </Li> <Li> Smooth, painful lymph gland swelling called a bubo, commonly found in the groin, but may occur in the armpits or neck, most often near the site of the initial infection (bite or scratch) </Li> <Li> Pain may occur in the area before the swelling appears </Li> <Li> Gangrene of the extremities such as toes, fingers, lips and tip of the nose . </Li>

When was the cure for the bubonic plague discovered