<P> Fullmetal Alchemist takes place in an alternate history, in the fictional country of Amestris (アメストリス, Amesutorisu). In this world, alchemy is one of the most - practiced sciences; Alchemists who work for the government are known as State Alchemists (国家 錬金術 師, Kokka Renkinjutsushi) and are automatically given the rank of Major in the military . Alchemists have the ability, with the help of patterns called Transmutation Circles, to create almost anything they desire . However, when they do so, they must provide something of equal value in accordance with the Law of Equivalent Exchange . The only things Alchemists are forbidden from transmuting are humans and gold . There has never been a successful human transmutation; those who attempt it lose a part of their body and the result is a horrific inhuman mass . Attemptees are confronted by Truth (真理, Shinri), a pantheistic and semi-cerebral God - like being who tauntingly regulates all alchemy use and whose nigh - featureless appearance is relative to the person to whom Truth is conversing with; the series' antagonist, Father, and some other characters, claim and believe that Truth is a personal God who punishes the arrogant, a belief that Edward denies, citing a flaw in Father's interpretation of Truth's works . </P> <P> Attemptees of Human Transmutation are also thrown into the Gate of Truth (真理 の 扉, Shinri no Tobira), where they receive an overwhelming dose of information, but also allowing them to transmute without a circle . All living things possess their own Gate of Truth, and per the Gaea hypothesis heavenly bodies like planets also have their own Gates of Truth . It is possible to bypass the Law of Equivalent Exchange (to an extent) using a Philosopher's Stone, a red, enigmatic substance . Philosopher's Stones can be used to create Homunculi, artificial humans of proud nature . Homunculi have numerous superhuman abilities unique amongst each other and look down upon all humanity . With the exception of one, they do not age and can only be killed via the destruction of their Philosopher's Stones . </P> <P> There are several cities throughout Amestris . The main setting is the capital of Central City (セントラル シティ, Sentoraru Shiti), along with other military cities such as the northern city of Briggs (ブリッグズ, Burigguzu). Towns featured include Resembool (リゼンブール, Rizenbūru), the rural hometown of the Elrics; Liore (リオール, Riōru), a city tricked into following a cult; Rush Valley (ラッシュ バレー, Rasshu Barē), a town that specializes in automail manufacturing; and Ishbal, a conservative - religion region that rejects alchemy and was destroyed in the Ishbalan Civil War instigated after a soldier (actually the homunculus Envy) shot an Ishbalan child . Outside of Amestris, there are few named countries, and none are seen in the main story . The main foreign country is Xing . Heavily reminiscent of China, Xing has a complex system of clans and emperors, as opposed to Amestris's government - controlled election of a Führer . It also has its own system of alchemy, called Alkahestry (錬 丹 術, Rentanjutsu), which is more medical and can be bi-located using kunai; in turn, it is implied that all countries have different forms of alchemy . </P> <P> Edward and Alphonse Elric live in the rural town of Resembool with their mother Trisha, their father Van Hohenheim having left without a reason . Edward since bore a grudge against their father as he and Alphonse showed a talent for alchemy before Trisha died of the plague . After finishing their alchemy training under Izumi Curtis, the brothers attempt to bring their mother back with alchemy . But the transmutation backfires and in law with equivalent exchange, Edward lost his left leg while Alphonse was dragged into the Gate of Truth . Edward sacrifices his right arm to retrieve Alphonse's soul, binding it to a suit of armor with a blood seal . Edward is invited by Roy Mustang to become a State Alchemist to research a way to restore Alphonse's body, passing his exams while given the title of Fullmetal Alchemist back on his prosthetic automail limbs and use of metal in his alchemy . The Elrics spent the next three years searching for the mythical Philosopher's Stone to achieve their goals . One such lead resulted in them exposing a corrupt religious leader in the city of Liore while unaware of events occurring behind the scenes by the mysterious Homunculi . </P>

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