<Tr> <Th> Synonyms </Th> <Td> Moschcowitz syndrome </Td> </Tr> <Tr> <Th> Specialty </Th> <Td> hematology </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood - coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body, resulting in low platelet counts . These small blood clots, called thrombi, can damage many organs including the kidneys, heart, brain, and nervous system . In the era before effective treatment with plasma exchange, the fatality rate was about 90% . With plasma exchange, this has dropped to 10% at six months . Because the disease generally results from antibodies that activate the immune system to inhibit the ADAMTS13 enzyme, agents that suppress the immune system, such as glucocorticoids, rituximab, cyclophosphamide, vincristine, or ciclosporin, may also be used if a relapse or recurrence follows plasma exchange . Platelets are not transfused unless the patient has a life - threatening bleed, since the transfused platelets would also quickly be consumed by thrombi formation, leading to a minimal increase in circulating platelets . </P>

Thrombotic thrombocytopenic purpura does not result in which of the following