<P> In atrial myocytes, ANP is made as a precursor form, i.e. prepro - ANP, a polypeptide of 151 amino acids . After the signal peptide is removed in the endoplasmic reticulum, the 126 - amino - acid pro-ANP is stored in the intracellular granules . When the cells are stimulated, pro-ANP is released and converted to the 28 - amino - acid C - terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin . </P> <P> ANP is secreted in response to: </P> <Ul> <Li> Stretching of the atrial wall, via Atrial volume receptors </Li> <Li> Increased Sympathetic stimulation of β - adrenoceptors </Li> <Li> Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion </Li> <Li> Endothelin, a potent vasoconstrictor </Li> </Ul> <Li> Stretching of the atrial wall, via Atrial volume receptors </Li>

What stimulus will cause the secretion of anh (atrial natriuretic hormone)
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