<P> As the disease became better understood, more effective treatments were found . An antimicrobial used for treating disease was the organo - arsenical drug Salvarsan, developed in 1908 by Sahachiro Hata in the laboratory of Nobel prize winner Paul Ehrlich . This group later discovered the related arsenic, Neosalvarsan, which is less toxic . </P> <P> It was observed that sometimes patients who developed high fevers were cured of syphilis . Thus, for a brief time malaria was used as treatment for tertiary syphilis because it produced prolonged and high fevers (a form of pyrotherapy). This was considered an acceptable risk because the malaria could later be treated with quinine, which was available at that time . Malaria as a treatment for syphilis was usually reserved for late disease, especially neurosyphilis, and then followed by either Salvarsan or Neosalvarsan as adjuvant therapy . This discovery was championed by Julius Wagner - Jauregg, who won the 1927 Nobel Prize for Medicine for his discovery of the therapeutic value of malaria inoculation in the treatment of neurosyphilis . Later, hyperthermal cabinets (sweat - boxes) were used for the same purpose . These treatments were finally rendered obsolete by the discovery of penicillin, and its widespread manufacture after World War II allowed syphilis to be effectively and reliably cured . </P> <P> In 1905, Schaudinn and Hoffmann discovered Treponema pallidum in tissue of patients with syphilis . One year later, the first effective test for syphilis, the Wassermann test, was developed . Although it had some false positive results, it was a major advance in the detection and prevention of syphilis . By allowing testing before the acute symptoms of the disease had developed, this test allowed the prevention of transmission of syphilis to others, even though it did not provide a cure for those infected . In the 1930s the Hinton test, developed by William Augustus Hinton, and based on flocculation, was shown to have fewer false positive reactions than the Wassermann test . Both of these early tests have been superseded by newer analytical methods . </P> <P> While working at the Rockefeller University (then called the Rockefeller Institute for Medical Research) in 1913, Hideyo Noguchi, a Japanese scientist, demonstrated the presence of the spirochete Treponema pallidum in the brain of a progressive paralysis patient, associating Treponema pallidum with neurosyphilis . Prior to Noguchi's discovery, syphilis had been a burden to humanity in many lands . Without its cause being understood, it was sometimes misdiagnosed and often misattributed to damage by political enemies . It is called "the great pretender" for its variety of symptoms . Felix Milgrom developed a test for syphilis . The Hideyo Noguchi Africa Prize was named to honor the man who identified the agent in association with the late form of the infectious disease . </P>

Who invented and gave his name to the blood test for syphilis
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