<P> In 1854, Dr. Wilhelm Gollmann addressed gonorrhea in his book, Homeopathic Guide to all Diseases Urinary and Sexual Organs . He noted that the disease was common in prostitutes and homosexuals in large cities . Gollmann recommended the following as cures: aconite to cure "shooting pains with soreness and inflammation;" mercury "for stitching pain with purulent discharge;" nux vomica and sulphur "when the symptoms are complicated with hemorrhoids and stricture of the rectum . Other remedies include argentum, aurum (gold), belladonna, calcarea, ignatia, phosphorus, and sepia . </P> <P> Silver nitrate was one of the widely used drugs in the 19th century . However, It became replaced by Protargol . Arthur Eichengrün invented this type of colloidal silver, which was marketed by Bayer from 1897 on . The silver - based treatment was used until the first antibiotics came into use in the 1940s . </P> <P> The exact time of onset of gonorrhea as prevalent disease or epidemic cannot be accurately determined from the historical record . One of the first reliable notations occurs in the Acts of the (English) Parliament . In 1161, this body passed a law to reduce the spread of "...the perilous infirmity of burning". The symptoms described are consistent with, but not diagnostic of, gonorrhea . A similar decree was passed by Louis IX in France in 1256, replacing regulation with banishment . Similar symptoms were noted at the siege of Acre by Crusaders . </P> <P> Coincidental to, or dependent on, the appearance of a gonorrhea epidemic, several changes occurred in European medieval society . Cities hired public health doctors to treat afflicted patients without right of refusal . Pope Boniface rescinded the requirement that physicians complete studies for the lower orders of the Catholic priesthood . </P>

When was the first case of gonorrhea discovered
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