<Tr> <Td_colspan="4"> <Table> <Tr> <Th_colspan="4"> show Gene ontology </Th> </Tr> <Tr> <Th> Molecular function </Th> <Td> type 1 angiotensin receptor binding hormone activity superoxide - generating NADPH oxidase activator activity growth factor activity type 2 angiotensin receptor binding protein binding sodium channel regulator activity serine - type endopeptidase inhibitor activity angiotensin receptor binding receptor ligand activity </Td> </Tr> <Tr> <Th> Cellular component </Th> <Td> cytoplasm extracellular exosome blood microparticle extracellular space cytosol extracellular region </Td> </Tr> <Tr> <Th> Biological process </Th> <Td> uterine smooth muscle contraction renal system process regulation of extracellular matrix assembly vasoconstriction positive regulation of cholesterol esterification positive regulation of catalytic activity positive regulation of cardiac muscle hypertrophy phospholipase C - activating G - protein coupled receptor signaling pathway cell surface receptor signaling pathway cellular response to mechanical stimulus blood vessel remodeling positive regulation of reactive oxygen species metabolic process stress - activated MAPK cascade artery smooth muscle contraction positive regulation of extrinsic apoptotic signaling pathway regulation of systemic arterial blood pressure by renin - angiotensin regulation of apoptotic process positive regulation of cellular protein metabolic process regulation of blood vessel size negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of branching involved in ureteric bud morphogenesis regulation of long - term neuronal synaptic plasticity positive regulation of renal sodium excretion kidney development positive regulation of fibroblast proliferation cellular sodium ion homeostasis ERK1 and ERK2 cascade activation of phospholipase C activity angiotensin maturation positive regulation of extracellular matrix constituent secretion positive regulation of transcription, DNA - templated positive regulation of blood pressure negative regulation of cell growth positive regulation of peptidyl - tyrosine phosphorylation regulation of norepinephrine secretion positive regulation of inflammatory response catenin import into nucleus female pregnancy positive regulation of protein tyrosine kinase activity negative regulation of tissue remodeling regulation of heart rate regulation of blood pressure positive regulation of macrophage derived foam cell differentiation regulation of vasoconstriction positive regulation of NF - kappaB transcription factor activity positive regulation of NAD (P) H oxidase activity nitric oxide mediated signal transduction G - protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger smooth muscle cell proliferation positive regulation of epidermal growth factor receptor signaling pathway regulation of blood volume by renin - angiotensin regulation of cardiac conduction regulation of calcium ion transport regulation of transmission of nerve impulse regulation of blood vessel diameter by renin - angiotensin cell growth involved in cardiac muscle cell development regulation of renal sodium excretion positive regulation of cytokine production positive regulation of membrane hyperpolarization response to muscle activity involved in regulation of muscle adaptation negative regulation of sodium ion transmembrane transporter activity positive regulation of nitric oxide biosynthetic process cytokine secretion angiotensin - mediated drinking behavior cell - cell signaling renin - angiotensin regulation of aldosterone production aging vasodilation positive regulation of endothelial cell migration low - density lipoprotein particle remodeling regulation of cell proliferation regulation of cell growth positive regulation of cell proliferation fibroblast proliferation negative regulation of angiogenesis positive regulation of gap junction assembly positive regulation of phosphatidylinositol 3 - kinase signaling positive regulation of superoxide anion generation positive regulation of L - lysine import across plasma membrane positive regulation of glucose import in response to insulin stimulus positive regulation of cardiac muscle cell apoptotic process angiotensin - activated signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of cytosolic calcium ion concentration negative regulation of gene expression regulation of renal output by angiotensin negative regulation of endopeptidase activity positive regulation of vascular associated smooth muscle cell migration regulation of molecular function positive regulation of activation of Janus kinase activity regulation of lipid metabolic process positive regulation of blood vessel diameter positive regulation of L - arginine import across plasma membrane regulation of receptor activity G - protein coupled receptor signaling pathway positive regulation of neuron projection development response to estradiol cellular response to angiotensin </Td> </Tr> <Tr> <Td_colspan="4"> Sources: Amigo / QuickGO </Td> </Tr> </Table> </Td> </Tr> <Table> <Tr> <Th_colspan="4"> show Gene ontology </Th> </Tr> <Tr> <Th> Molecular function </Th> <Td> type 1 angiotensin receptor binding hormone activity superoxide - generating NADPH oxidase activator activity growth factor activity type 2 angiotensin receptor binding protein binding sodium channel regulator activity serine - type endopeptidase inhibitor activity angiotensin receptor binding receptor ligand activity </Td> </Tr> <Tr> <Th> Cellular component </Th> <Td> cytoplasm extracellular exosome blood microparticle extracellular space cytosol extracellular region </Td> </Tr> <Tr> <Th> Biological process </Th> <Td> uterine smooth muscle contraction renal system process regulation of extracellular matrix assembly vasoconstriction positive regulation of cholesterol esterification positive regulation of catalytic activity positive regulation of cardiac muscle hypertrophy phospholipase C - activating G - protein coupled receptor signaling pathway cell surface receptor signaling pathway cellular response to mechanical stimulus blood vessel remodeling positive regulation of reactive oxygen species metabolic process stress - activated MAPK cascade artery smooth muscle contraction positive regulation of extrinsic apoptotic signaling pathway regulation of systemic arterial blood pressure by renin - angiotensin regulation of apoptotic process positive regulation of cellular protein metabolic process regulation of blood vessel size negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of branching involved in ureteric bud morphogenesis regulation of long - term neuronal synaptic plasticity positive regulation of renal sodium excretion kidney development positive regulation of fibroblast proliferation cellular sodium ion homeostasis ERK1 and ERK2 cascade activation of phospholipase C activity angiotensin maturation positive regulation of extracellular matrix constituent secretion positive regulation of transcription, DNA - templated positive regulation of blood pressure negative regulation of cell growth positive regulation of peptidyl - tyrosine phosphorylation regulation of norepinephrine secretion positive regulation of inflammatory response catenin import into nucleus female pregnancy positive regulation of protein tyrosine kinase activity negative regulation of tissue remodeling regulation of heart rate regulation of blood pressure positive regulation of macrophage derived foam cell differentiation regulation of vasoconstriction positive regulation of NF - kappaB transcription factor activity positive regulation of NAD (P) H oxidase activity nitric oxide mediated signal transduction G - protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger smooth muscle cell proliferation positive regulation of epidermal growth factor receptor signaling pathway regulation of blood volume by renin - angiotensin regulation of cardiac conduction regulation of calcium ion transport regulation of transmission of nerve impulse regulation of blood vessel diameter by renin - angiotensin cell growth involved in cardiac muscle cell development regulation of renal sodium excretion positive regulation of cytokine production positive regulation of membrane hyperpolarization response to muscle activity involved in regulation of muscle adaptation negative regulation of sodium ion transmembrane transporter activity positive regulation of nitric oxide biosynthetic process cytokine secretion angiotensin - mediated drinking behavior cell - cell signaling renin - angiotensin regulation of aldosterone production aging vasodilation positive regulation of endothelial cell migration low - density lipoprotein particle remodeling regulation of cell proliferation regulation of cell growth positive regulation of cell proliferation fibroblast proliferation negative regulation of angiogenesis positive regulation of gap junction assembly positive regulation of phosphatidylinositol 3 - kinase signaling positive regulation of superoxide anion generation positive regulation of L - lysine import across plasma membrane positive regulation of glucose import in response to insulin stimulus positive regulation of cardiac muscle cell apoptotic process angiotensin - activated signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of cytosolic calcium ion concentration negative regulation of gene expression regulation of renal output by angiotensin negative regulation of endopeptidase activity positive regulation of vascular associated smooth muscle cell migration regulation of molecular function positive regulation of activation of Janus kinase activity regulation of lipid metabolic process positive regulation of blood vessel diameter positive regulation of L - arginine import across plasma membrane regulation of receptor activity G - protein coupled receptor signaling pathway positive regulation of neuron projection development response to estradiol cellular response to angiotensin </Td> </Tr> <Tr> <Td_colspan="4"> Sources: Amigo / QuickGO </Td> </Tr> </Table> <Tr> <Th_colspan="4"> show Gene ontology </Th> </Tr> <Tr> <Th> Molecular function </Th> <Td> type 1 angiotensin receptor binding hormone activity superoxide - generating NADPH oxidase activator activity growth factor activity type 2 angiotensin receptor binding protein binding sodium channel regulator activity serine - type endopeptidase inhibitor activity angiotensin receptor binding receptor ligand activity </Td> </Tr>

How does angiotensin ii (ang ii) directly affect the kidneys