<Li> Within the H - zone is a thin M - line (from the German "Mittelscheibe", the disc in the middle of the sarcomere) formed of cross-connecting elements of the cytoskeleton . </Li> <P> The relationship between the proteins and the regions of the sarcomere are as follows: </P> <Ul> <Li> Actin filaments, the thin filaments, are the major component of the I - band and extend into the A-band . </Li> <Li> Myosin filaments, the thick filaments, are bipolar and extend throughout the A-band . They are cross-linked at the centre by the M - band . </Li> <Li> The giant protein titin (connectin) extends from the Z - line of the sarcomere, where it binds to the thick filament (myosin) system, to the M - band, where it is thought to interact with the thick filaments . Titin (and its splice isoforms) is the biggest single highly elasticated protein found in nature . It provides binding sites for numerous proteins and is thought to play an important role as sarcomeric ruler and as blueprint for the assembly of the sarcomere . </Li> <Li> Another giant protein, nebulin, is hypothesised to extend along the thin filaments and the entire I - Band . Similar to titin, it is thought to act as a molecular ruler along for thin filament assembly . </Li> <Li> Several proteins important for the stability of the sarcomeric structure are found in the Z - line as well as in the M - band of the sarcomere . </Li> <Li> Actin filaments and titin molecules are cross-linked in the Z - disc via the Z - line protein alpha - actinin . </Li> <Li> The M - band proteins myomesin as well as C - protein crosslink the thick filament system (myosins) and the M - band part of titin (the elastic filaments). </Li> <Li> The M - line also binds creatine kinase, which facilitates the reaction of ADP and phosphocreatine into ATP and creatine . </Li> <Li> The interaction between actin and myosin filaments in the A-band of the sarcomere is responsible for the muscle contraction (sliding filament model). </Li> </Ul> <Li> Actin filaments, the thin filaments, are the major component of the I - band and extend into the A-band . </Li>

Where are myosin filaments located in the sarcomere
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