<Tr> <Th_colspan="2"> Other data </Th> </Tr> <Tr> <Th> Locus </Th> <Td> Chr. 14 q21 - q22 </Td> </Tr> <P> Estrogen receptors (ERs) are a group of proteins found inside cells . They are receptors that are activated by the hormone estrogen (17β - estradiol). Two classes of ER exist: nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER - X, and G - mER), which are mostly G protein - coupled receptors . This article refers to the former (ER). </P> <P> Once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different genes (i.e. it is a DNA - binding transcription factor). However, it also has additional functions independent of DNA binding . </P>

Where are estrogen receptors located in the body