<P> Apart from the latter two, which occur in excitable cells (neurons, muscles, and some secretory cells in glands), membrane voltage in the majority of non-excitable cells can also undergo changes in response to environmental or intracellular stimuli . In principle, there is no difference between resting membrane potential and dynamic voltage changes like action potential from a biophysical point of view: all these phenomena are caused by specific changes in membrane permeabilities for potassium, sodium, calcium, and chloride ions, which in turn result from concerted changes in functional activity of various ion channels, ion transporters, and exchangers . Conventionally, resting membrane potential can be defined as a relatively stable, ground value of transmembrane voltage in animal and plant cells . </P> <P> Any voltage is a difference in electric potential between two points--for example, the separation of positive and negative electric charges on opposite sides of a resistive barrier . The typical resting membrane potential of a cell arises from the separation of potassium ions from intracellular, relatively immobile anions across the membrane of the cell . Because the membrane permeability for potassium is much higher than that for other ions (disregarding voltage - gated channels at this stage), and because of the strong chemical gradient for potassium, potassium ions flow from the cytosol into the extracellular space carrying out positive charge, until their movement is balanced by build - up of negative charge on the inner surface of the membrane . Again, because of the high relative permeability for potassium, the resulting membrane potential is almost always close to the potassium reversal potential . But in order for this process to occur, a concentration gradient of potassium ions must first be set up . This work is done by the ion pumps / transporters and / or exchangers and generally is powered by ATP . </P> <P> In the case of the resting membrane potential across an animal cell's plasma membrane, potassium (and sodium) gradients are established by the Na / K - ATPase (sodium - potassium pump) which transports 2 potassium ions inside and 3 sodium ions outside at the cost of 1 ATP molecule . In other cases, for example, a membrane potential may be established by acidification of the inside of a membranous compartment (such as the proton pump that generates membrane potential across synaptic vesicle membranes). </P> <P> In most quantitative treatments of membrane potential, such as the derivation of Goldman equation, electroneutrality is assumed; that is, that there is no measurable charge excess in any side of the membrane . So, although there is an electric potential across the membrane due to charge separation, there is no actual measurable difference in the global concentration of positive and negative ions across the membrane (as it is estimated below), that is, there is no actual measurable charge excess on either side . That occurs because the effect of charge on electrochemical potential is hugely greater than the effect of concentration so an undetectable change in concentration creates a great change in electric potential . </P>

Role of sodium-potassium pump in resting membrane potential
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