<P> The genotype--a term coined by Danish botanist, plant physiologist and geneticist Wilhelm Johannsen in 1903--is the part (DNA sequence) of the genetic makeup of a cell, and therefore of an organism or individual, which determines a specific characteristic (phenotype) of that cell / organism / individual . Genotype is one of three factors that determine phenotype, the other two being inherited epigenetic factors, and non-inherited environmental factors . DNA mutations which are acquired rather than inherited, such as cancer mutations, are not part of the individual's genotype; hence, scientists and physicians sometimes talk for example about the (geno) type of a particular cancer, that is the genotype of the disease as distinct from the diseased . </P> <P> An example of how genotype determines a characteristic is petal color in a pea plant . </P> <P> The genotype of an organism is the inherited map it carries within its genetic code . Not all organisms with the same genotype look or act the same way because appearance and behavior are modified by environmental and developmental conditions . Likewise, not all organisms that look alike necessarily have the same genotype . One's genotype differs subtly from one's genomic sequence . A sequence is an absolute measure of base composition of an individual, or a representative of a species or group; a genotype typically implies a measurement of how an individual differs or is specialized within a group of individuals or a species . So, typically, one refers to an individual's genotype with regard to a particular gene of interest and, in polyploid individuals, it refers to what combination of alleles the individual carries (see homozygous, heterozygous). The genetic constitution of an organism is referred to as its genotype, such as the letters Bb (B--dominant genotype and b--recessive genotype). </P> <P> Any given gene will usually cause an observable change in an organism, known as the phenotype . The terms genotype and phenotype are distinct for at least two reasons: </P>

The combination of alleles of an organism is referred to as the organism's