<Tr> <Td_colspan="2"> Footnotes / references More </Td> </Tr> <P> Coordinates: 44 ° 1 ′ 20" N 92 ° 28 ′ 0" W ﻿ / ﻿ 44.02222 ° N 92.46667 ° W ﻿ / 44.02222; - 92.46667 </P> <P> The Mayo Clinic is a nonprofit academic medical center based in Rochester, Minnesota, focused on integrated clinical practice, education, and research . It employs more than 4,500 physicians and scientists and 58,400 administrative and allied health staff . The practice specializes in treating difficult cases through tertiary care . It spends over $660 million a year on research and employs over 3,000 full - time research personnel . </P> <P> William Worrall Mayo settled his family in Rochester in 1863 and opened a for - profit medical practice that evolved under his sons into Mayo Clinic . Mayo Clinic is widely regarded as one of the United States' greatest hospitals and ranked No. 1 in the country on the 2018--2019 U.S. News & World Report List of "Best Hospitals" of the United States, maintaining a position near the top for more than 27 years . It has been on the list of "100 Best Companies to Work For" published by Fortune magazine for fourteen consecutive years, and has continued to achieve this ranking through 2017 . </P>

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