<Ul> <Li> This rapid partitioning model is the most drastic alteration of the traditional vesicular trafficking point of view . Proponents of this model hypothesize that the Golgi works as a single unit, containing domains that function separately in the processing and export of protein cargo . Cargo from the ER move between these two domains, and randomly exit from any level of the Golgi to their final location . This model is supported by the observation that cargo exits the Golgi in a pattern best described by exponential kinetics . The existence of domains is supported by fluorescence microscopy data . <Ul> <Li> Strengths: Notably, this model explains the exponential kinetics of cargo exit of both large and small proteins whereas other models cannot . </Li> <Li> Weaknesses: This model cannot explain the transport kinetics of large protein cargo, such as collagen . This model falls short on explaining the observation of discrete compartments and polarized biochemistry of the Golgi cisternae . It also does not explain formation and disintegration of the Golgi network, nor the role of COPI vesicles . </Li> </Ul> </Li> </Ul> <Li> This rapid partitioning model is the most drastic alteration of the traditional vesicular trafficking point of view . Proponents of this model hypothesize that the Golgi works as a single unit, containing domains that function separately in the processing and export of protein cargo . Cargo from the ER move between these two domains, and randomly exit from any level of the Golgi to their final location . This model is supported by the observation that cargo exits the Golgi in a pattern best described by exponential kinetics . The existence of domains is supported by fluorescence microscopy data . <Ul> <Li> Strengths: Notably, this model explains the exponential kinetics of cargo exit of both large and small proteins whereas other models cannot . </Li> <Li> Weaknesses: This model cannot explain the transport kinetics of large protein cargo, such as collagen . This model falls short on explaining the observation of discrete compartments and polarized biochemistry of the Golgi cisternae . It also does not explain formation and disintegration of the Golgi network, nor the role of COPI vesicles . </Li> </Ul> </Li> <Ul> <Li> Strengths: Notably, this model explains the exponential kinetics of cargo exit of both large and small proteins whereas other models cannot . </Li> <Li> Weaknesses: This model cannot explain the transport kinetics of large protein cargo, such as collagen . This model falls short on explaining the observation of discrete compartments and polarized biochemistry of the Golgi cisternae . It also does not explain formation and disintegration of the Golgi network, nor the role of COPI vesicles . </Li> </Ul> <Li> Strengths: Notably, this model explains the exponential kinetics of cargo exit of both large and small proteins whereas other models cannot . </Li>

Function of the golgi apparatus in eukaryotic cells