<Li> Malassezia globosa, a fungus that is thought to be the cause of human dandruff, uses lipase to break down sebum into oleic acid and increase skin cell production, causing dandruff . </Li> <P> The main lipases of the human digestive system are pancreatic lipase (PL) and pancreatic lipase related protein 2 (PLRP2), which are secreted by the pancreas . Humans also have several other related enzymes, including hepatic lipase, endothelial lipase, and lipoprotein lipase . Not all of these lipases function in the gut (see table). </P> <Table> <Tr> <Td> Name </Td> <Td> Gene </Td> <Td> Location </Td> <Td> Description </Td> <Td> Disorder </Td> </Tr> <Tr> <Td> bile salt - dependent lipase </Td> <Td> bsdl </Td> <Td> pancreas, breast milk </Td> <Td> aids in the digestion of fats </Td> <Td> </Td> </Tr> <Tr> <Td> pancreatic lipase </Td> <Td> PNLIP </Td> <Td> digestive juice </Td> <Td> In order to exhibit optimal enzyme activity in the gut lumen, PL requires another protein, colipase, which is also secreted by the pancreas . </Td> <Td> </Td> </Tr> <Tr> <Td> lysosomal lipase </Td> <Td> LIPA </Td> <Td> interior space of organelle: lysosome </Td> <Td> Also referred to as lysosomal acid lipase (LAL or LIPA) or acid cholesteryl ester hydrolase </Td> <Td> Cholesteryl ester storage disease (CESD) and Wolman disease are both caused by mutations in the gene encoding lysosomal lipase . </Td> </Tr> <Tr> <Td> hepatic lipase </Td> <Td> LIPC </Td> <Td> endothelium </Td> <Td> Hepatic lipase acts on the remaining lipids carried on lipoproteins in the blood to regenerate LDL (low density lipoprotein). </Td> <Td> - </Td> </Tr> <Tr> <Td> lipoprotein lipase </Td> <Td> LPL or "LIPD" </Td> <Td> endothelium </Td> <Td> Lipoprotein lipase functions in the blood to act on triacylglycerides carried on VLDL (very low density lipoprotein) so that cells can take up the freed fatty acids . </Td> <Td> Lipoprotein lipase deficiency is caused by mutations in the gene encoding lipoprotein lipase . </Td> </Tr> <Tr> <Td> hormone - sensitive lipase </Td> <Td> LIPE </Td> <Td> intracellular </Td> <Td> - </Td> <Td> - </Td> </Tr> <Tr> <Td> gastric lipase </Td> <Td> LIPF </Td> <Td> digestive juice </Td> <Td> Functions in the infant at a near - neutral pH to aid in the digestion of lipids </Td> <Td> - </Td> </Tr> <Tr> <Td> endothelial lipase </Td> <Td> LIPG </Td> <Td> endothelium </Td> <Td> - </Td> <Td> - </Td> </Tr> <Tr> <Td> pancreatic lipase related protein 2 </Td> <Td> PNLIPRP2 or "PLRP2" - </Td> <Td> digestive juice </Td> <Td> - </Td> <Td> - </Td> </Tr> <Tr> <Td> pancreatic lipase related protein 1 </Td> <Td> PNLIPRP1 or "PLRP1" </Td> <Td> digestive juice </Td> <Td> Pancreatic lipase related protein 1 is very similar to PLRP2 and PL by amino acid sequence (all three genes probably arose via gene duplication of a single ancestral pancreatic lipase gene). However, PLRP1 is devoid of detectable lipase activity and its function remains unknown, even though it is conserved in other mammals . </Td> <Td> - </Td> </Tr> <Tr> <Td> lingual lipase </Td> <Td>? </Td> <Td> saliva </Td> <Td> Active at gastric pH levels . Optimum pH is about 3.5 - 6 . Secreted by several of the salivary glands (Ebner's glands at the back of the tongue (lingua), the sublingual glands, and the parotid glands) </Td> <Td> - </Td> </Tr> </Table> <Tr> <Td> Name </Td> <Td> Gene </Td> <Td> Location </Td> <Td> Description </Td> <Td> Disorder </Td> </Tr>

Give two places in the body that produce lipases