<P> ALS is the central topic of the 2014 movie You're Not You, directed by George C. Wolfe, with Hilary Swank, Emmy Rossum and Josh Duhamel playing the main characters . </P> <P> HBO's VICE, covered ALS in Season 4 Episode 16: Die Trying . </P> <P> Repetitive transcranial magnetic stimulation had been studied in ALS in small and poorly designed clinical trials; as of 2013, there was insufficient evidence to know whether rTMS is safe or effective for ALS . </P> <P> One 2016 review of stem cell therapy trials found tentative evidence that intraspinal stem cell implantation was relatively safe and possibly effective . A 2016 Cochrane review of cell based therapies found that there was insufficient evidence to speculate about efficacy . Stem cell therapy can provide additional proteins and enzymes that have shown to help prolong survival and control the symptoms associated with ALS . Those proteins include neurotrophic factors and insulin - like growth factor 1 . Both those proteins are still under clinical trials and need to be further studied to evaluate their efficiency and associated side effects . </P>

When was the first case of als discovered