<Tr> <Td_colspan="2"> Anatomical terms of microanatomy (edit on Wikidata) </Td> </Tr> <P> The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone - producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans . The pancreatic islets constitute 1 to 2% of the pancreas volume and receive 10--15% of its blood flow . The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose . </P> <P> There are about 3 million islets distributed in the form of density routes throughout the pancreas of a healthy adult human, each of which measures an average of about 0.1 mm (109 μm) in diameter . Each is separated from the surrounding pancreatic tissue by a thin fibrous connective tissue capsule which is continuous with the fibrous connective tissue that is interwoven throughout the rest of the pancreas . The combined mass of the islets is 2 grams . Islets of Langerhans can also form superstructures called islet clusters surrounding large blood vessels . The roundness of islets along the pancreas has also been quantified as an index of sphericity . Islets closest to the spherical form are mainly found in the tail of the pancreas, whereas the least - spherical islets are found in the neck of the pancreas . </P> <P> Hormones produced in the pancreatic islets are secreted directly into the blood flow by (at least) five types of cells . In rat islets, endocrine cell subsets are distributed as follows: </P>

Where is the islets of langerhans gland located