<Li> 10 or fewer rotatable bonds and </Li> <Li> Polar surface area no greater than 140 Ǻ </Li> <P> are predicted to have good oral bioavailability . </P> <P> During drug discovery, lipophilicity and molecular weight are often increased in order to improve the affinity and selectivity of the drug candidate . Hence it is often difficult to maintain drug - likeness (i.e., RO5 compliance) during hit and lead optimization . Hence it has been proposed that members of screening libraries from which hits are discovered should be biased toward lower molecular weight and lipophility so that medicinal chemists will have an easier time in delivering optimized drug development candidates that are also drug - like . Hence the rule of five has been extended to the rule of three (RO3) for defining lead - like compounds . </P>

Which of the following is one of the rules in lipinski's rule of five