<Table> <Tr> <Td> </Td> <Td> This article may require cleanup to meet Wikipedia's quality standards . The specific problem is: the article reproduces content from other articles, reproducing / introducing problems: (i) material lacking citations, (ii) extensive information marginally germane to the title subject (on generalities, rather than mechanism). Please help improve this article if you can . (June 2016) (Learn how and when to remove this template message) </Td> </Tr> </Table> <Tr> <Td> </Td> <Td> This article may require cleanup to meet Wikipedia's quality standards . The specific problem is: the article reproduces content from other articles, reproducing / introducing problems: (i) material lacking citations, (ii) extensive information marginally germane to the title subject (on generalities, rather than mechanism). Please help improve this article if you can . (June 2016) (Learn how and when to remove this template message) </Td> </Tr> <P> Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever . Much of this is believed to be due to decreased production of prostaglandins and TXA2 . Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme . Cyclooxygenase is required for prostaglandin and thromboxane synthesis . Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme . This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors . However, other effects of aspirin, such as uncoupling oxidative phosphorylation in mitochondria, and the modulation of signaling through NF - κB, are also being investigated . Some of its effects are like those of salicylic acid, which is not an acetylating agent . </P> <Table> <Tr> <Td> </Td> <Td> This section may stray from the topic of the article into the topic of another article, ((instead of covering the hist . discov. of the mechanism of action of aspirin, per se)). Please help improve this section or discuss this issue on the talk page . (June 2016) </Td> </Tr> </Table>

What is the mode of action of aspirin
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