<P> Toxicology is a discipline, overlapping with biology, chemistry, pharmacology, medicine, and nursing, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants . The relationship between dose and its effects on the exposed organism is of high significance in toxicology . Factors that influence chemical toxicity include the dosage (and whether it is acute or chronic), route of exposure, species, age, sex, and environment . Toxicologists are experts on poisons and poisoning . </P> <P> Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect . Ibn Wahshiyya wrote the Book on Poisons in the 9th or 10th century . This was followed up in 1360 by Khagendra Mani Darpana . </P> <P> Mathieu Orfila is considered the modern father of toxicology, having given the subject its first formal treatment in 1813 in his Traité des poisons, also called Toxicologie générale . </P> <P> In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue . This allowed him to identify the use of nicotine as a poison in the famous Bocarmé murder case, providing the evidence needed to convict the Belgian Count Hippolyte Visart de Bocarmé of killing his brother - in - law . </P>

Who is known as the father of toxicology