<P> In the aftermath, Gargamel wakes up and learns that he is still in the present and he looks at the audience before breaking the fourth wall and asking them "What are you looking at?" and blasts them with his wand . </P> <Ul> <Li> Hank Azaria as Gargamel, the nemesis of the Smurfs who plots to use the Smurfs as part of a spell which would turn lead into gold . As opposed to the television show where Gargamel's goal is to use the Smurfs as the key ingredient in an alchemical formula to create gold or eat them or destroy them, in the film he wants to capture them to serve as charms, "whose mystical essence will make his inept magic more powerful--and dangerous". To look the part of Gargamel, Azaria wore a prosthetic nose, ears, buck teeth, eyebrows, and a wig (to make the process easier, he shaved his head). The initial make - up test took three hours, but by mid-production, the process took 90 minutes to complete . Azaria was transformed over 50 times and spent approximately 130 hours in the make - up chair . </Li> <Li> Neil Patrick Harris as Patrick "Pat" Winslow, the new VP of marketing at Anjelou Cosmetics </Li> <Li> Jayma Mays as Grace Winslow, Patrick's pregnant wife </Li> <Li> Sofía Vergara as Odile Anjelou, an executive at Anjelou Cosmetics who is Patrick's boss . </Li> <Li> Tim Gunn as Henri, Odile's executive assistant at Anjelou Cosmetics . </Li> <Li> Paula Pizzi as Odile's Mother </Li> </Ul> <Li> Hank Azaria as Gargamel, the nemesis of the Smurfs who plots to use the Smurfs as part of a spell which would turn lead into gold . As opposed to the television show where Gargamel's goal is to use the Smurfs as the key ingredient in an alchemical formula to create gold or eat them or destroy them, in the film he wants to capture them to serve as charms, "whose mystical essence will make his inept magic more powerful--and dangerous". To look the part of Gargamel, Azaria wore a prosthetic nose, ears, buck teeth, eyebrows, and a wig (to make the process easier, he shaved his head). The initial make - up test took three hours, but by mid-production, the process took 90 minutes to complete . Azaria was transformed over 50 times and spent approximately 130 hours in the make - up chair . </Li> <Li> Neil Patrick Harris as Patrick "Pat" Winslow, the new VP of marketing at Anjelou Cosmetics </Li>

Who played gargamel in the first smurfs movie