<Li> Tamsulosin (α blocker) </Li> <Li> Udenafil (PDE5 inhibitor) </Li> <P> Sulfonamides have the potential to cause a variety of untoward reactions, including urinary tract disorders, haemopoietic disorders, porphyria, and hypersensitivity reactions . When used in large doses, they may cause a strong allergic reaction . Two of the most serious are Stevens--Johnson syndrome and toxic epidermal necrolysis (also known as Lyell syndrome). </P> <P> Approximately 3% of the general population have adverse reactions when treated with sulfonamide antimicrobials . Of note is the observation that patients with HIV have a much higher prevalence, at about 60% . </P>

What are the indications for use of sulphonamides