<P> Intermediate filaments are most commonly known as the support system or "scaffolding" for the cell and nucleus while also playing a role in some cell functions . In combination with proteins and desmosomes, the intermediate filaments form cell - cell connections and anchor the cell - matrix junctions that are used in messaging between cells as well as vital functions of the cell . These connections allow the cell to communicate through the desmosome of multiple cells to adjust structures of the tissue based on signals from the cells environment . Mutations in the IF proteins have been shown to cause serious medical issues such as premature aging, desmin mutations compromising organs, Alexander Disease, and muscular dystrophy . </P> <P> Different intermediate filaments are: </P> <Ul> <Li> made of vimentins . Vimentin intermediate filaments are in general present in mesenchymal cells . </Li> <Li> made of keratin . Keratin is present in general in epithelial cells . </Li> <Li> neurofilaments of neural cells . </Li> <Li> made of lamin, giving structural support to the nuclear envelope . </Li> <Li> made of desmin, play an important role in structural and mechanical support of muscle cells . </Li> </Ul> <Li> made of vimentins . Vimentin intermediate filaments are in general present in mesenchymal cells . </Li>

Where is the cytoskeleton located in a cell