<P> A canaliculus is an adaptation found on gastric parietal cells . It is a deep infolding, or little channel, which serves to increase the surface area, e.g. for secretion . The parietal cell membrane is dynamic; the numbers of canaliculi rise and fall according to secretory need . This is accomplished by the fusion of canalicular precursors, or "tubulovesicles", with the membrane to increase surface area, and the reciprocal endocytosis of the canaliculi (reforming the tubulovesicles) to decrease it . </P> <P> Hydrochloric acid is formed in the following manner: </P> <Ul> <Li> Hydrogen ions are formed from the dissociation of carbonic acid . Water is a very minor source of hydrogen ions in comparison to carbonic acid . Carbonic acid is formed from carbon dioxide and water by carbonic anhydrase . </Li> <Li> The bicarbonate ion (HCO) is exchanged for a chloride ion (Cl) on the basal side of the cell and the bicarbonate diffuses into the venous blood, leading to an alkaline tide phenomenon . </Li> <Li> Potassium (K) and chloride (Cl) ions diffuse into the canaliculi . </Li> <Li> Hydrogen ions are pumped out of the cell into the canaliculi in exchange for potassium ions, via the H / K ATPase . These receptors are increased in number on luminal side by fusion of tubulovesicles during activation of parietal cells and removed during deactivation . This receptor maintains a million fold difference in proton concentration . ATP is provided by the numerous mitochondria . </Li> </Ul> <Li> Hydrogen ions are formed from the dissociation of carbonic acid . Water is a very minor source of hydrogen ions in comparison to carbonic acid . Carbonic acid is formed from carbon dioxide and water by carbonic anhydrase . </Li>

How is hcl produced by parietal cells in the stomach
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