<Tr> <Th> Box office </Th> <Td> $300.1 million </Td> </Tr> <P> Stuart Little is a 1999 American live - action / computer animated family film directed by Rob Minkoff . It is loosely based on the novel by E.B. White . It combines live action and computer animation . The screenplay was written by M. Night Shyamalan and Greg Brooker . The plot bears little resemblance to that of the book, as only some of the characters and one or two minor plot elements are the same . The film's sequel more closely resembles the original novel . </P> <P> In this, Minkoff's first live - action film, Michael J. Fox is the voice of Stuart Little . Geena Davis and Hugh Laurie star as Eleanor and Frederick Little, with Jonathan Lipnicki as Stuart's big brother George and Nathan Lane as the voice of the family cat Snowbell . </P> <P> The film was released on December 17, 1999, by Columbia Pictures . It received an Academy Award for Best Visual Effects nomination, but lost to The Matrix . The film, the first in the film series, spawned a sequel in 2002, Stuart Little 2, the short - lived television series Stuart Little: The Animated Series in 2003, and another sequel in 2005, the direct - to - video Stuart Little 3: Call of the Wild . </P>

Who plays snowball the cat in stuart little