<P> Amelia Shepherd is the youngest sister of Dr. Derek Shepherd, and like her brother, an excellent neurosurgeon . Her ambition to prove herself equal to her brother is only surpassed by her surgical skill . After graduating in the top of her class at Harvard and completing her surgical residency at Johns Hopkins, she comes to Los Angeles on a medical case and decides to stay after she is fired from her fellowship . She asks Naomi Bennett for a job when the two practices merge . She has known Dr. Addison Montgomery for many years and views her as a close friend and surrogate sister . As a young woman, she was addicted to prescription medication and crashed Derek's car while high . When she came home, she overdosed and was dead for three minutes . Derek saved her life, but was and still is angry with her . Amelia ended up sleeping with Derek's best friend Mark Sloan, following in the footsteps of her sister Nancy and her ex sister - in - law Addison Montgomery after making peace with Derek following his own shooting . </P> <P> Amelia first appeared in season three, brought in because her boss was called for a consult on a comatose patient of Addison Montgomery's . Amelia came up with a plan, which was not approved by her boss, to wake the patient from her coma . The family of the patient urged her to perform the surgery which lead her to be fired from the original job she had . She soon begins to hang around Oceanside Wellness, annoying Addison a bit with her free - living attitude but also giving advice on Addison's relationship with Sam . Amelia was also the surgeon who operated on Dell Parker after the car crash . As season 4 begins, Amelia is reluctant to visit her brother, Derek, when he is shot, but Addison eventually encourages her to go to Seattle to see him . On the way, Amelia has an in - flight romance with a man with a brain tumor and brings him to Seattle Grace for surgery . She and Derek bicker constantly over the surgery, but eventually settle their differences . She also has a one - night stand with Mark Sloan . When she returns to Los Angeles, she learns that there is a merger going on between the two practices . Amelia asks Naomi Bennett if she could become Ocean Wellness' new neurosurgeon, a move that annoys Addison . </P> <P> When Charlotte is attacked and raped, Amelia is out with Cooper and Sam, but after receiving a visit from Violet, she comes to Charlotte's aid and confides in Charlotte about her addiction to prescription drugs and alcohol while stitching up a laceration on her arm . Later, when a drunken Cooper makes a move on Amelia, she rebuffs his advances and tells him to go home to his fiancée . Cooper eventually tells Charlotte about his interaction with Amelia and though Charlotte confronts her, they remain good friends . Charlotte asks Amelia to be her maid of honor in the episode "Something Old, Something New". At the wedding reception Amelia asks for a glass of ginger ale instead of champagne but by accident gets champagne, which she spits out . By the end of the season, however, Amelia relapses into addiction and refuses to get the help suggested by Charlotte . Charlotte tries to intervene with meetings, but Amelia skips them . Later, Charlotte discovers that Amelia operated on a patient while she was under the influence and as a result, Charlotte revokes all of her medical privileges . </P> <P> Amelia continues her downward spiral in the premiere, injuring herself at a bar falling down drunk . Sheldon picks her up and takes her to the hospital where she sutures herself up in private to avoid Charlotte . The two later find out Pete has had a heart attack and needs surgery . Furthermore, Amelia operates on Pete's brain while under the influence . Later, Amelia passes a breathalizer test, but is seen drinking alone at home in Addison's old condo . Amelia's friend with Huntington's disease returns from Italy and requests Amelia's help with physician - assisted suicide . Pete and Sheldon disagree over Amelia's decision to help her . Later, Amelia and Pete discuss Pete's past when he reveals he once assisted a dying patient . Later Amelia begins a benzodiazepine injection on her friend, who has an adverse reaction and requests to be saved before she stops breathing; Amelia rushes her to the hospital, where Pete tends to her friend . Shortly after discovering her friend had completed her own suicide after being rescued, Amelia consumes what is believed to be three OxyContin pills she palmed after discovering the friend's body . </P>

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