<Ul> <Li> James Franco as Dr. William "Will" Rodman, a biologist who is trying to discover a cure for his father's Alzheimer's disease by testing ALZ - 112 on chimps . He is a father figure to Caesar . James Franco was cast after talks with Tobey Maguire broke down . </Li> <Li> Freida Pinto as Dr. Caroline Aranha, a primatologist who begins a relationship with Will and grows attached to Caesar . </Li> <Li> John Lithgow as Charles Rodman, Will's Alzheimer's - afflicted father and a former music teacher who improves after Will gives him the ALZ - 112 and forms a grandfatherly bond with Caesar . </Li> <Li> Brian Cox as John Landon, manager of the San Bruno Primate Shelter where Caesar is confined for a time . His full name is a reference to one of the astronauts in the original Planet of the Apes . </Li> <Li> Tom Felton as Dodge Landon, John's son and an animal caretaker at the shelter, who abuses the apes for sport . His first and last name are references to two of the astronauts in the original Planet of the Apes . </Li> <Li> David Oyelowo as Steven Jacobs, Will's arrogant boss . His last name is a reference to Arthur P. Jacobs, the producer of the original Planet of the Apes series . </Li> <Li> Tyler Labine as Robert Franklin, a chimp handler at Gen - Sys and one of Will's friends . His surname is a reference to Franklin Schaffner, the director of the original film . </Li> <Li> Jamie Harris as Rodney, a caretaker and a nightwatchman who is much kinder to the apes at the sanctuary and is regularly mocked by Dodge for this . </Li> <Li> David Hewlett as Hunsiker, Will's hot - headed neighbor . </Li> <Li> Chelah Horsdal as Irena, a nurse who is looking after Charles . </Li> </Ul> <Li> James Franco as Dr. William "Will" Rodman, a biologist who is trying to discover a cure for his father's Alzheimer's disease by testing ALZ - 112 on chimps . He is a father figure to Caesar . James Franco was cast after talks with Tobey Maguire broke down . </Li> <Li> Freida Pinto as Dr. Caroline Aranha, a primatologist who begins a relationship with Will and grows attached to Caesar . </Li> <Li> John Lithgow as Charles Rodman, Will's Alzheimer's - afflicted father and a former music teacher who improves after Will gives him the ALZ - 112 and forms a grandfatherly bond with Caesar . </Li>

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