<P> LMNA missense mutation (c. 1580G> T) introduced at LMNA gene--position 1580 (nt) in the DNA sequence (CGT) causing the guanine to be replaced with the thymine, yielding CTT in the DNA sequence . This results at the protein level in the replacement of the arginine by the leucine at the position 527 . This leads to destruction of salt bridge and structure destabilization . At phenotype level this manifests with overlapping mandibuloacral dysplasia and progeria syndrome . </P> <P> The resulting transcript and protein product is: </P> <P> Cancer associated missense mutations can lead to drastic destabilisation of the resulting protein . A novel method to screen for such changes was proposed recently, namely fast parallel proteolysis (FASTpp). </P>

An example of a missense mutation would be changing cga to ___