<Table> <Tr> <Th_colspan="4"> NPPA </Th> </Tr> <Tr> <Td_colspan="4"> </Td> </Tr> <Tr> <Td_colspan="4"> <Table> <Tr> <Th_colspan="4"> Available structures </Th> </Tr> <Tr> <Th> PDB </Th> <Td_colspan="2"> Ortholog search: PDBe RCSB </Td> </Tr> <Tr> <Td> <Table> <Tr> <Th_colspan="2"> (show) List of PDB id codes </Th> </Tr> <Tr> <Td_colspan="2"> <P> 1ANP, 1YK0, 3N57 </P> </Td> </Tr> </Table> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th_colspan="4"> Identifiers </Th> </Tr> <Tr> <Th> Aliases </Th> <Td_colspan="3"> NPPA, ANF, ANP, ATFB6, ATRST2, CDD, CDD - ANF, CDP, PND, Atrial natriuretic peptide, natriuretic peptide A </Td> </Tr> <Tr> <Th> External IDs </Th> <Td_colspan="3"> OMIM: 108780 MGI: 97367 HomoloGene: 4498 GeneCards: NPPA </Td> </Tr> <Tr> <Td_colspan="4"> <Table> <Tr> <Th_colspan="4"> (hide) Gene location (Human) </Th> </Tr> <Tr> <Td_colspan="4"> </Td> </Tr> <Tr> <Th> Chr . </Th> <Td_colspan="3"> Chromosome 1 (human) </Td> </Tr> <Tr> <Td_colspan="4"> </Td> </Tr> <Tr> <Th> Band </Th> <Td> 1p36. 22 </Td> <Th> Start </Th> <Td> 11,845,709 bp </Td> </Tr> <Tr> <Th> End </Th> <Td> 11,848,345 bp </Td> </Tr> </Table> </Td> </Tr> <Tr> <Td_colspan="4"> <Table> <Tr> <Th_colspan="4"> (show) Gene location (Mouse) </Th> </Tr> <Tr> <Td_colspan="4"> </Td> </Tr> <Tr> <Th> Chr . </Th> <Td_colspan="3"> Chromosome 4 (mouse) </Td> </Tr> <Tr> <Td_colspan="4"> </Td> </Tr> <Tr> <Th> Band </Th> <Td> 4 E2 4 78.66 cM </Td> <Th> Start </Th> <Td> 148,000,722 bp </Td> </Tr> <Tr> <Th> End </Th> <Td> 148,002,079 bp </Td> </Tr> </Table> </Td> </Tr> <Tr> <Td_colspan="4"> <Table> <Tr> <Th_colspan="4"> (show) Gene ontology </Th> </Tr> <Tr> <Th> Molecular function </Th> <Td> neuropeptide receptor binding hormone activity peptide hormone receptor binding neuropeptide hormone activity protein binding receptor binding hormone receptor binding </Td> </Tr> <Tr> <Th> Cellular component </Th> <Td> cytoplasm mast cell granule nucleus perinuclear region of cytoplasm extracellular region extracellular space protein complex extracellular matrix </Td> </Tr> <Tr> <Th> Biological process </Th> <Td> response to muscle stretch positive regulation of cardiac muscle contraction response to hypoxia regulation of high voltage - gated calcium channel activity neuropeptide signaling pathway female pregnancy regulation of cardiac conduction negative regulation of collecting lymphatic vessel constriction positive regulation of potassium ion export across plasma membrane cellular protein metabolic process regulation of blood vessel size positive regulation of heart rate positive regulation of delayed rectifier potassium channel activity cGMP biosynthetic process regulation of blood pressure negative regulation of systemic arterial blood pressure regulation of calcium ion transmembrane transport via high voltage - gated calcium channel transcription initiation from RNA polymerase II promoter regulation of atrial cardiac muscle cell membrane repolarization response to insulin cell growth involved in cardiac muscle cell development negative regulation of cell growth cardiac muscle hypertrophy in response to stress cellular response to mechanical stimulus receptor guanylyl cyclase signaling pathway protein folding regulation of receptor activity positive regulation of histamine secretion by mast cell </Td> </Tr> <Tr> <Td_colspan="4"> Sources: Amigo / QuickGO </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th_colspan="4"> Orthologs </Th> </Tr> <Tr> <Th> Species </Th> <Td> Human </Td> <Td> Mouse </Td> </Tr> <Tr> <Th> Entrez </Th> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> 4878 </P> </Td> </Tr> </Table> </Td> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> 230899 </P> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th> Ensembl </Th> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> ENSG00000175206 </P> </Td> </Tr> </Table> </Td> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> ENSMUSG00000041616 </P> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th> UniProt </Th> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> P01160 </P> </Td> </Tr> </Table> </Td> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> P05125 </P> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th> RefSeq (mRNA) </Th> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> NM_006172 </P> </Td> </Tr> </Table> </Td> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> NM_008725 </P> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th> RefSeq (protein) </Th> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> NP_006163 </P> </Td> </Tr> </Table> </Td> <Td> <Table> <Tr> <Th_colspan="1"> </Th> </Tr> <Tr> <Td_colspan="1"> <P> NP_032751 </P> </Td> </Tr> </Table> </Td> </Tr> <Tr> <Th> Location (UCSC) </Th> <Td> Chr 1: 11.85--11.85 Mb </Td> <Td> Chr 1: 148--148 Mb </Td> </Tr> <Tr> <Th> PubMed search </Th> <Td> </Td> <Td> </Td> </Tr> <Tr> <Td_colspan="4"> Wikidata </Td> </Tr> <Tr> <Td_colspan="4"> <Table> <Tr> <Td_colspan="2"> View / Edit Human </Td> <Td_colspan="2"> View / Edit Mouse </Td> </Tr> </Table> </Td> </Tr> </Table> <Tr> <Th_colspan="4"> NPPA </Th> </Tr>

Elevated levels of the hormones anp and bnp