<Li> Expansion of bone marrow in infants and children with severe chronic hemolysis - changes in bone configuration visible on X-ray </Li> <Li> The balance between red cell destruction and marrow compensation determines the severity of anemias . </Li> <P> In a healthy person, a red blood cell survives 90 to 120 days in the circulation, so about 1% of human red blood cells break down each day . The spleen (part of the reticulo - endothelial system) is the main organ that removes old and damaged RBCs from the circulation . In healthy individuals, the breakdown and removal of RBCs from the circulation is matched by the production of new RBCs in the bone marrow . </P> <P> In conditions where the rate of RBC breakdown is increased, the body initially compensates by producing more RBCs; however, breakdown of RBCs can exceed the rate that the body can make RBCs, and so anemia can develop . Bilirubin, a breakdown product of hemoglobin, can accumulate in the blood, causing jaundice . </P>

Which causes the failure of erythrocytes to nature