<Tr> <Td_colspan="2"> View / Edit Human </Td> <Td_colspan="2"> View / Edit Mouse </Td> </Tr> <P> The epidermal growth factor receptor (EGFR; ErbB - 1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands . </P> <P> The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB - 1), HER2 / neu (ErbB - 2), Her 3 (ErbB - 3) and Her 4 (ErbB - 4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer . </P> <P> Epidermal growth factor and its receptor was discovered by Stanley Cohen of Vanderbilt University . Cohen shared the 1986 Nobel Prize in Medicine with Rita Levi - Montalcini for their discovery of growth factors . </P>

Epidermal growth factor receptor cell proliferation signaling pathways