<Tr> <Td> Brain </Td> <Td> BRA </Td> </Tr> <Tr> <Td> Distant lymph nodes </Td> <Td> LYM </Td> </Tr> <Tr> <Td> Bone marrow </Td> <Td> MAR </Td> </Tr> <Tr> <Td> Pleura </Td> <Td> PLE </Td> </Tr>

A characteristic of the stage of progression in the development of cancer is