<Li> Semiopen orthomitosis occurs with different variants in some amoebae (Lobosa) and some green flagellates (e.g., Raphidophyta or Volvox). </Li> <Li> Open orthomitosis is typical in mammals and other Metazoa, and in land plants; but it also occurs in some protists . </Li> <P> Errors can occur during mitosis, especially during early embryonic development in humans . Mitotic errors can create aneuploid cells that have too few or too many of one or more chromosomes, a condition associated with cancer . Early human embryos, cancer cells, infected or intoxicated cells can also suffer from pathological division into three or more daughter cells (tripolar or multipolar mitosis), resulting in severe errors in their chromosomal complements . </P> <P> In nondisjunction, sister chromatids fail to separate during anaphase . One daughter cell receives both sister chromatids from the nondisjoining chromosome and the other cell receives none . As a result, the former cell gets three copies of the chromosome, a condition known as trisomy, and the latter will have only one copy, a condition known as monosomy . On occasion, when cells experience nondisjunction, they fail to complete cytokinesis and retain both nuclei in one cell, resulting in binucleated cells . </P>

In a dividing cell the mitotic (m) phase alternates with interphase (i) a growth period