<Ul> <Li> Leukotrienes are eicosanoid lipid mediators made by the metabolism of arachidonic acid by ALOX5 (also termed 5 - lipoxygenase). Their most prominent member with chemotactic factor activity is leukotriene B4, which elicits adhesion, chemotaxis, and aggregation of leukocytes . The chemoattractant action of LTB4 is induced via either of two G protein--coupled receptors, BLT 1 and BLT2, which are highly expressed in cells involved in inflammation and allergy . </Li> <Li> The family of 5 - Hydroxyicosatetraenoic acid eicosanoids are arachidonic acid metabolites also formed by ALOX5 . Three members of the family form naturally and have prominent chemotactic activity . These, listed in order of decreasing potency, are: 5 - oxo - eicosatetraenoic acid, 5 - oxo - 15 - hydroxy - eicosatetraenoic acid, and 5 - Hydroxyeicosatetraenoic acid . This family of agonists stimulates chemotactic responses in human eosinophils, neutrophils, and monocytes by binding to the Oxoeicosanoid receptor 1, which like the receptors for leukotriene B4, is a G protein - coupled receptor . Aside from the skin, neutrophils are the body's first line of defense against bacterial infections . After leaving nearby blood vessels, these cells recognize chemicals produced by bacteria in a cut or scratch and migrate "toward the smell". </Li> <Li> 5 - hydroxyeicosatrieonic acid and 5 - oxoeicosatrienoic acid are metabolites of Mead acid (5Z, 8Z, 11Z - eicosatrirenoid acid); they stimulate leukocyte chemotaxis through the oxoeicosanoid receptor 1 with 5 - oxoeicosatrienoic acid being as potent as its arachidonic acid - derived analog, 5 - oxo - eicosatetraenoic acid, in stimulating human blood eosinophil and neutrophil chemotaxis . </Li> <Li> 12 - Hydroxyeicosatetraenoic acid is an eicosanoid metabolite of arachidonic acid made by ALOX12 which stimulates leukocyte chemotaxis through the leukotriene B4 receptor, BLT2 . </Li> <Li> Prostaglandin D2 is an eicosanoid metabolite of arachidononic acid made by cyclooxygenase 1 or cyclooxygenase 2 that stimulates chemotaxis through the Prostaglandin DP2 receptor . It elicits chemotactic responses in eosinophils, basophils, and T helper cells of the Th2 subtype . </Li> <Li> 12 - Hydroxyheptadecatrienoic acid is a non-eicosanoid metabolite of arachidonic acid made by cyclooxygenase 1 or cyclooxygenase 2 that stimulates leukocyte chemataxis though the leukotriene B4 receptor, BLT2 . </Li> <Li> 15 - oxo - eicosatetraenoic acid is an eicosanoid metabolite of arachidonic acid made my ALOX15; it has weak chemotactic activity for human monocytes (sees 15 - Hydroxyeicosatetraenoic acid #15 - oxo - ETE). The receptor or other mechanism by which this metabolite stimulates chemotaxis has not been elucidated . </Li> </Ul> <Li> Leukotrienes are eicosanoid lipid mediators made by the metabolism of arachidonic acid by ALOX5 (also termed 5 - lipoxygenase). Their most prominent member with chemotactic factor activity is leukotriene B4, which elicits adhesion, chemotaxis, and aggregation of leukocytes . The chemoattractant action of LTB4 is induced via either of two G protein--coupled receptors, BLT 1 and BLT2, which are highly expressed in cells involved in inflammation and allergy . </Li> <Li> The family of 5 - Hydroxyicosatetraenoic acid eicosanoids are arachidonic acid metabolites also formed by ALOX5 . Three members of the family form naturally and have prominent chemotactic activity . These, listed in order of decreasing potency, are: 5 - oxo - eicosatetraenoic acid, 5 - oxo - 15 - hydroxy - eicosatetraenoic acid, and 5 - Hydroxyeicosatetraenoic acid . This family of agonists stimulates chemotactic responses in human eosinophils, neutrophils, and monocytes by binding to the Oxoeicosanoid receptor 1, which like the receptors for leukotriene B4, is a G protein - coupled receptor . Aside from the skin, neutrophils are the body's first line of defense against bacterial infections . After leaving nearby blood vessels, these cells recognize chemicals produced by bacteria in a cut or scratch and migrate "toward the smell". </Li> <Li> 5 - hydroxyeicosatrieonic acid and 5 - oxoeicosatrienoic acid are metabolites of Mead acid (5Z, 8Z, 11Z - eicosatrirenoid acid); they stimulate leukocyte chemotaxis through the oxoeicosanoid receptor 1 with 5 - oxoeicosatrienoic acid being as potent as its arachidonic acid - derived analog, 5 - oxo - eicosatetraenoic acid, in stimulating human blood eosinophil and neutrophil chemotaxis . </Li>

What cells are able to move in a swimming motion