<P> Perhaps the most important plasma proteins are the albumins as they are present in relatively high concentrations and they readily bind to other substances . Other important proteins include the glycoproteins, the lipoproteins and to a lesser degree the globulins . </P> <P> It is therefore easy to see that clinical conditions that modify the levels of plasma proteins (for example, hypoalbuminemias brought on by renal dysfunction) may affect the effect and toxicity of a drug that has a binding rate with plasma proteins of above 90% . </P> <P> Highly lipid - soluble drugs given by intravenous or inhalation routes are initially distributed to organs with high blood flow . Later, less vascular but more bulky tissues (such as muscle and fat) take up the drug--plasma concentration falls and the drug is withdrawn from these sites . If the site of action of the drug was in one of the highly perfused organs, redistribution results in termination of the drug action . The greater the lipid solubility of the drug, the faster its redistribution will be . For example, the anaesthetic action of thiopentone is terminated in a few minutes due to redistribution . However, when the same drug is given repeatedly or continuously over long periods, the low - perfusion and high - capacity sites are progressively filled up and the drug becomes longer - acting . </P> <P> It is reversible process of moving drug of sites of highly perfused to systemic circulation, FMAS </P>

Where do lipid soluble drugs concentrate in the body
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