<Li> Key: RMRJXGBAOAMLHD - IHFGGWKQSA - N </Li> <Tr> <Th_colspan="2"> (what is this?) (verify) </Th> </Tr> <P> Buprenorphine, sold under the brand name Subutex, among others, is an opioid used to treat opioid addiction, acute pain, and chronic pain . It can be used under the tongue, by injection, as a skin patch, or as an implant . For opioid addiction it is typically only started when withdrawal symptoms have begun and for the first two days of treatment under direct observation of a health care provider . For longer term treatment of addiction a combination formulation of buprenorphine / naloxone is recommended to prevent misuse by injection . Maximum pain relief is generally within an hour with effects up to 24 hours . </P> <P> Side effects may include respiratory depression (decreased breathing), sleepiness, adrenal insufficiency, QT prolongation, low blood pressure, allergic reactions, and opioid addiction . Among those with a history of seizures, there is a risk of further seizures . Opioid withdrawal following stopping buprenorphine is generally less severe than with other opioids . It is unclear if use during pregnancy is safe and use while breastfeeding is not recommended . Buprenorphine affects different types of opioid receptors in different ways . Depending on the type of receptor it may be an agonist, partial agonist, or antagonist . </P>

Bupernorphine (buprenex® subutex® suboxone®) is used to treat which substance use disorder