<P> At the front part of the cribriform plate, on either side of the crista galli, is a small fissure that is occupied by a process of dura mater . </P> <P> Lateral to this fissure is a notch or foramen which transmits the nasociliary nerve; from this notch a groove extends backward to the anterior ethmoidal foramen . </P> <P> A fractured cribriform plate (anterior skull trauma) can result in leaking of cerebrospinal fluid into the nose and loss of sense of smell . The tiny apertures of the plate transmitting the olfactory nerve become the route of ascent for a pathogen, Naegleria fowleri . This amoeba tends to destroy the olfactory bulb and the adjacent inferior surface of the frontal lobe of the brain . This surface initially becomes the site of proliferation of the trophozoites of Naegleria fowleri and their subsequent spread to the rest of the brain and CSF . Because of its initial involvement and trophozoite presence in early phases of Naegleria fowleri infection, flushing of this region with saline using a device, to obtain Naegelria fowleri for diagnostic PCR and microscopic viewing has been proposed for patients affected by Primary Amoebic Meningoencephalitis (PAM), by (Baig AM., et al) in a recent publication . Reseachers have suggested the same route to administer drugs at an early phase of infection by using a "Transcribrial Device" that has been proposed to kill this pathogen at a place of its maximum proliferation . In a 2017 the inventor of the device has suggested that after slight modifications this method could be effective in delivery of stem cells to the brain as well A recent Australian study as shown that bacterium causing the tropical disease melioidosis, Burkholderia pseudomallei can also invade the brain via the olfactory nerve within 24 h by transversing the cribriform plate . </P> <P> The Keros classification is a method of classifying the depth of the olfactory fossa . </P>

What is the significance of the cribriform plate of the ethmoid bone
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