<P> A 2014 meta - analysis from the Cochrane Collaboration found the antidepressant duloxetine to be effective for the treatment of pain resulting from diabetic neuropathy . The same group reviewed data for amitriptyline in the treatment of neuropathic pain and found limited useful randomized clinical trial data . They concluded that the long history of successful use in the community for the treatment of fibromyalgia and neuropathic pain justified its continued use . The group was concerned about the potential for overestimating the amount of pain relief provided by amitriptyline, and highlighted that only a small number of people will experience significant pain relief by taking this medication . </P> <P> Antidepressants may be modestly helpful for treating people who both have depression and alcohol dependence, however the evidence supporting this association of low quality . </P> <P> Difficulty tolerating adverse effects is the most common reason for antidepressant discontinuation . </P> <P> Almost any medication involved with serotonin regulation has the potential to cause serotonin toxicity (also known as serotonin syndrome)--an excess of serotonin that can induce mania, restlessness, agitation, emotional lability, insomnia and confusion as its primary symptoms . Although the condition is serious, it is not particularly common, generally only appearing at high doses or while on other medications . Assuming proper medical intervention has been taken (within about 24 hours) it is rarely fatal . </P>

The first group of drugs developed and used to treat depression were