<Li> Sutures and ties - Sutures are often used to close an open wound, allowing for the injured area to stay free of pathogens and other unwanted debris to enter the site; however, it is also essential to the process of hemostasis . Sutures and ties allow for skin to be joined back together allowing for platelets to start the process of hemostasis at a quicker pace . Using sutures results in a quicker recovery period because the surface area of the wound has been decreased . </Li> <Li> Physical agents (gelatin sponge) - Gelatin sponges have been indicated as great hemostatic devices . Once applied to a bleeding area, a gelatin sponge quickly stops or reduces the amount of bleeding present . These physical agents are mostly used in surgical settings as well as after surgery treatments . These sponges absorb blood, allow for coagulation to occur faster, and give off chemical responses that decrease the time it takes for the hemostasis pathway to start . </Li> <P> The body's hemostasis system requires careful regulation in order to work properly . If the blood does not clot sufficiently, it may be due to bleeding disorders such as hemophilia or immune thrombocytopenia; this requires careful investigation . Over-active clotting can also cause problems; thrombosis, where blood clots form abnormally, can potentially cause embolisms, where blood clots break off and subsequently become lodged in a vein or artery . </P> <P> Hemostasis disorders can develop for many different reasons . They may be congenital, due to a deficiency or defect in an individual's platelets or clotting factors . A number of disorders can be acquired as well, such as in HELLP syndrome, which is due to pregnancy, or Hemolytic - uremic syndrome (HUS), which is due to E. coli toxins . </P>

Which is the correct sequence of responses involved in hemostasis