<Li> Integral monotopic proteins are integral membrane proteins that are attached to only one side of the membrane and do not span the whole way across . </Li> <P> Peripheral membrane proteins are temporarily attached either to the lipid bilayer or to integral proteins by a combination of hydrophobic, electrostatic, and other non-covalent interactions . Peripheral proteins dissociate following treatment with a polar reagent, such as a solution with an elevated pH or high salt concentrations . </P> <P> Integral and peripheral proteins may be post-translationally modified, with added fatty acid or prenyl chains, or GPI (glycosylphosphatidylinositol), which may be anchored in the lipid bilayer . </P> <P> Polypeptide toxins and many antibacterial peptides, such as colicins or hemolysins, and certain proteins involved in apoptosis, are sometimes considered a separate category . These proteins are water - soluble but can aggregate and associate irreversibly with the lipid bilayer and become reversibly or irreversibly membrane - associated . </P>

Where are membrane bound proteins made in the cell