<Tr> <Td_colspan="3">--Francis Crick </Td> </Tr> <P> A second version of the central dogma is popular but incorrect . This is the simplistic DNA → RNA → protein pathway published by James Watson in the first edition of The Molecular Biology of the Gene (1965). Watson's version differs from Crick's because Watson describes the two - step (DNA → RNA and RNA → protein) pathway as the central dogma . While the dogma, as originally stated by Crick, remains valid today, Watson's version does not . </P> <P> The dogma is a framework for understanding the transfer of sequence information between information - carrying biopolymers, in the most common or general case, in living organisms . There are 3 major classes of such biopolymers: DNA and RNA (both nucleic acids), and protein . There are 3 × 3 = 9 conceivable direct transfers of information that can occur between these . The dogma classes these into 3 groups of 3: three general transfers (believed to occur normally in most cells), three special transfers (known to occur, but only under specific conditions in case of some viruses or in a laboratory), and three unknown transfers (believed never to occur). The general transfers describe the normal flow of biological information: DNA can be copied to DNA (DNA replication), DNA information can be copied into mRNA (transcription), and proteins can be synthesized using the information in mRNA as a template (translation). The special transfers describe: RNA being copied from RNA (RNA replication), DNA being synthesised using an RNA template (reverse transcription), and proteins being synthesised directly from a DNA template without the use of mRNA . The unknown transfers describe: a protein being copied from a protein, synthesis of RNA using the primary structure of a protein as a template, and DNA synthesis using the primary structure of a protein as a template - these are not thought to naturally occur . </P> <P> The biopolymers that comprise DNA, RNA and (poly) peptides are linear polymers (i.e.: each monomer is connected to at most two other monomers). The sequence of their monomers effectively encodes information . The transfers of information described by the central dogma ideally are faithful, deterministic transfers, wherein one biopolymer's sequence is used as a template for the construction of another biopolymer with a sequence that is entirely dependent on the original biopolymer's sequence . </P>

Where does the process of transcription fit into the central dogma of molecular genetics
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