<Li> Second cholera pandemic 1829--1851 . Reached Russia (see Cholera Riots), Hungary (about 100,000 deaths) and Germany in 1831, London in 1832 (more than 55,000 persons died in the United Kingdom), France, Canada (Ontario), and United States (New York City) in the same year, and the Pacific coast of North America by 1834 . A two - year outbreak began in England and Wales in 1848 and claimed 52,000 lives . It is believed that over 150,000 Americans died of cholera between 1832 and 1849 . </Li> <Li> Third pandemic 1852--1860 . Mainly affected Russia, with over a million deaths . Throughout Spain, cholera caused more than 236,000 deaths in 1854--55 . It claimed 200,000 lives in Mexico . </Li> <Li> Fourth pandemic 1863--1875 . Spread mostly in Europe and Africa . At least 30,000 of the 90,000 Mecca pilgrims fell victim to the disease . Cholera claimed 90,000 lives in Russia in 1866 . </Li> <Li> In 1866, there was an outbreak in North America . It killed some 50,000 Americans . </Li>

The five deadliest outbreaks and pandemics in history