<Dl> <Dd> (NH) CO + H O → CO + 2 NH </Dd> </Dl> <Dd> (NH) CO + H O → CO + 2 NH </Dd> <P> More specifically, urease catalyzes the hydrolysis of urea to produce ammonia and carbamate; the carbamate produced is subsequently degraded by spontaneous hydrolysis to produce another ammonia and carbonic acid . Urease activity tends to increase the pH of its environment as it produces ammonia, a basic molecule . Ureases are found in numerous bacteria, fungi, algae, plants and some invertebrates, as well as in soils, as a soil enzyme . They are nickel - containing metalloenzymes of high molecular weight . </P> <P> Its activity was first identified in 1876 by Frédéric Alphonse Musculus as a soluble ferment . In 1926, James B. Sumner, an assistant professor at Cornell University, showed that urease is a protein by examining its crystallized form . Sumner's work was the first demonstration that a pure protein can function as an enzyme, and led eventually to the recognition that most enzymes are in fact proteins, and the award of the Nobel prize in chemistry to Sumner in 1946 . The structure of urease was first solved by P.A. Karplus in 1995 . Urease was the first ever enzyme crystallized . </P>

To what class of enzymes does urease belong