<P> Grey's Anatomy is an American medical drama television series that premiered on American Broadcasting Company (ABC) as a mid-season replacement on March 27, 2005 . The series has aired for fourteen seasons, and focuses on the fictional lives of surgical interns and residents as they evolve into seasoned doctors while trying to maintain personal lives . The show's premise originated with Shonda Rhimes, who serves as an executive producer, along with Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg . The series was created to be racially diverse, utilizing a color - blind casting technique . It is primarily filmed in Los Angeles . The show's title is a play on Gray's Anatomy, the classic human anatomy textbook . </P> <P> Episodes have been broadcast on Thursday nights since Grey's third season . The first two seasons aired after Desperate Housewives in the Sunday 10: 00 pm EST time - slot . All episodes are approximately forty - three minutes, excluding commercials, and are broadcast in both high - definition and standard . Episodes are also available for download at the iTunes Store in standard and high definition, and Amazon Video, with new episodes appearing the day after their live airings . ABC Video on demand also releases episodes of the show, typically one to two days after their premieres . Recent episodes are available at ABC's official Grey's Anatomy website, and on Hulu . In 2010, ABC signed a deal allowing Grey's Anatomy episodes to be streamed on Netflix . </P>

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