<Tr> <Th> MeSH </Th> <Td> D006975 </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Portal hypertension is hypertension (high blood pressure) in the hepatic portal system, which are the portal vein and its branches, which drain from most of the intestines to the liver . Portal hypertension is defined as a hepatic venous pressure gradient . Cirrhosis (a form of chronic liver failure) is the most common cause of portal hypertension; other, less frequent causes are therefore grouped as non-cirrhotic portal hypertension . When it becomes severe enough to cause symptoms or complications, treatment may be given to decrease portal hypertension itself or to manage its complications . </P> <P> Signs and symptoms of portal hypertension include: </P>

What is the most common manifestation of portal hypertension–induced splenomegaly