<Table> <Tr> <Td> ← Previous "Break on Through" </Td> <Td> Next → "As We Know It" </Td> </Tr> </Table> <Tr> <Td> ← Previous "Break on Through" </Td> <Td> Next → "As We Know It" </Td> </Tr> <Tr> <Td_colspan="2"> Grey's Anatomy (season 2) List of Grey's Anatomy episodes </Td> </Tr> <P> "It's the End of the World" is the 16th episode of the second season of the ABC series, Grey's Anatomy . The episode was written by series creator Shonda Rhimes and directed by co-executive producer Peter Horton . This episode is the first of a two - part story, concluding its plot on the following episode, "As We Know It". It originally aired on February 5, 2006, serving as the lead - out program for the Super Bowl XL . On its original broadcast, "It's the End of the World" was watched by 38.1 million viewers . It is the highest rated and most watched episode of the series . </P>

The end of the world grey's anatomy