<P> Copper sulfate is an irritant . The usual routes by which humans can receive toxic exposure to copper sulfate are through eye or skin contact, as well as by inhaling powders and dusts . Skin contact may result in itching or eczema . Eye contact with copper sulfate can cause conjunctivitis, inflammation of the eyelid lining, ulceration, and clouding of the cornea . </P> <P> Upon oral exposure, copper sulfate is moderately toxic . According to studies, the lowest dose of copper sulfate that had a toxic effect on humans is 11 mg / kg . Because of its irritating effect on the gastrointestinal tract, vomiting is automatically initiated in case of the ingestion of copper sulfate . However, if copper sulfate is retained in the stomach, the symptoms can be severe . After 1--12 grams of copper sulfate are swallowed, such poisoning signs may occur as a metallic taste in the mouth, burning pain in the chest, nausea, diarrhea, vomiting, headache, discontinued urination, which leads to yellowing of the skin . In cases of copper sulfate poisoning, injury to the brain, stomach, liver, or kidneys may also occur . </P> <P> Copper sulfate is highly soluble in water and therefore is easy to distribute in the environment . Copper in the soil may be from industry, motor vehicle, and architectural materials . According to studies, copper sulfate exists mainly in the surface soil and tends to bind organic matter . The more acidic the soil is, the less binding occurs . </P>

Is copper ii sulfate pentahydrate soluble in water