<Tr> <Th> Health </Th> <Td> Beneficial </Td> </Tr> <P> Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot . It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair . The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin . Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis). </P> <P> Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel . Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma Factor VII, which ultimately leads to fibrin formation . Platelets immediately form a plug at the site of injury; this is called primary hemostasis . Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII (listed below) respond in a complex cascade to form fibrin strands, which strengthen the platelet plug . </P> <P> Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component . The system in humans has been the most extensively researched and is the best understood . </P>

When is the process of blood clotting activated
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