<P> Human knee osteoarthritis may have doubled since the mid-20th century, per a study of skeletons . </P> <P> Osteoarthritis is derived from the prefix osteo - (from Ancient Greek: ὀστέον, translit . ostéon, lit .' bone') combined with arthritis (from ἀρθρῖτῐς, arthrîtis, lit.' of or in the joint'), which is itself derived from arthr - (from ἄρθρον, árthron, lit .' joint, limb') and - itis (from - ῖτις, - îtis, lit .' pertaining to'), the latter suffix having come to be associated with inflammation . The - itis of osteoarthritis could be considered misleading as inflammation is not a conspicuous feature . Some clinicians refer to this condition as osteoarthrosis to signify the lack of inflammatory response, the suffix - osis (from - ωσις, - ōsis, lit .' (abnormal) state, condition, or action') simply referring to the pathosis itself . </P> <P> There are ongoing efforts to determine if there are agents that modify outcomes in osteoarthritis . Sprifermin is one candidate drug . There is also tentative evidence that strontium ranelate may decrease degeneration in osteoarthritis and improve outcomes . </P> <P> As well as attempting to find disease - modifying agents for osteoarthritis, there is emerging evidence that a system - based approach is necessary to find the causes of osteoarthritis . Changes may occur before clinical disease is evident due to abnormalities in biomechanics, biology or structure of joints that predispose them to develop clinical disease . Research is thus focusing on defining these early pre-osteoarthritis changes using biological, mechanical, and imaging markers of osteoarthritis risk, emphasising multi-disciplinary approaches, and looking into personalized interventions that can reverse osteoarthritis risk in healthy joints before the disease becomes evident . </P>

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