<P> Intracerebroventricular injection (ICVI) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier . Although this barrier effectively protects the brain, it can prevent important medications to enter the CNS . The technique is widely used in biomedical research to introduce drugs, therapeutic RNAs, plasmid DNAs, and viral vectors into the CNS of diseased mice models . It can also be used in human in cases of neurodegenerative disorders like spinal muscular atrophy (SMA), or administering chemotherapy in gliomas as well as delivering neurotrophic factors to CNS . </P> <P> Ommaya reservoir is a catheter system invented by Ayub Ommaya, a Pakistani neurosurgeon in 1963 . The reservoir is implanted under the scalp and attached to a catheter which is intracerebroventricularly inserted into the lateral ventricle . </P>

Icv (intracerebroventricular) injection of a drug involves injections into the