<Ul> <Li> Chris Rock as Osmosis "Ozzy" Jones, an overzealous blue and white blood cell with little respect for authority . Since he was discredited, he was suspended for unnecessary force and placed in out - of - the - way patrols for making Frank throw up all over Mrs. Boyd in front of public after seeing a virus in the oyster to keep Frank healthy . Therefore, he seizes any opportunity to be able to make a difference . He is able to combine his eyes into one, to ooze through narrow spaces like cracks and under doors, and to contort his body . </Li> <Li> Laurence Fishburne as Thrax, a tall, extremely virulent, pathogenic agent . Thrax is referred to as "The Red Death" (a common nickname for the Ebola virus) but does not appear to cause an existing disease, although he claims loudly, "Ebola is a case of dandruff compared to me!", and has killed numerous people before arriving in Frank . He carries a chain consisting of numerous chromosomes removed from his other victims' hypothalamus as a trophy . His left index finger is a long claw that can cause instant inflammation . This lets him bypass the blood - brain barrier, alter the properties of other cells, or outright kill them . Although Thrax is a virus, his name appears to be a pun on "anthrax"; despite the fact that the anthrax microbe is the bacteria bacillus Bacillus_anthracis rather than a virus . </Li> <Li> David Hyde Pierce as Drixenol "Drix" Koldreliff, a stoic cold pill who becomes Ozzy's best friend . His right arm is a cannon used to shoot an assorted variety of medication, including one that freezes any target . He is a follower of written rules and compensates for his doubts of himself by acting haughtily . He is intelligent, clever, and dedicated to work . Straight - laced and by - the - book, he is in disagreement with the crude humor and unorthodox methods of Ozzy, but respects Ozzy as a partner due to his dedication to fighting diseases . </Li> <Li> Brandy Norwood as Leah Estrogen, Mayor Phlegmming's secretary and Ozzy's love interest, greatly relied upon by him for her skills . She is one of few inhabitants of Frank who realize the flaws of the current administration and one of the few willing to believe Osmosis' claims of a large - scale infection . </Li> <Li> William Shatner as Mayor Phlegmming, the short, overweight, and self - centered mayor of the "City of Frank". He is constantly preoccupied with everything but his job, except when it concerns planning his re-election . His name is a pun on the word phlegm . </Li> <Li> Ron Howard as Tom Colonic, Phlegmming's rival for the mayoralty of the City of Frank . His political platform is diametrically opposed to the incumbent's, instead promoting less junk food and a healthier "City of Frank". His manner and attitude appears to be modeled after President John F. Kennedy . His name represents the human Colon . </Li> <Li> Joel Silver as the Police Chief, Ozzy's boss who works at the precinct . </Li> <Li> Steve Susskind as Mob Germ Boss </Li> <Li> Carlos Alazraqui as Spanish Germ . </Li> <Li> Rodger Bumpass as Announcer for Nerve News Network </Li> <Li> Kid Rock as Kidney Rock (voice) </Li> <Li> Kenny Olson as Kidney Rock (voice) </Li> <Li> Jason Krause as Kidney Rock (voice) </Li> <Li> Joe C. as Kidney Rock (voice) </Li> <Li> Stefanie Eulinberg as Kidney Rock (voice) </Li> <Li> Jimmie Bones as Kidney Rock (voice) </Li> <Li> Uncle Kracker as Kidney Rock (voice) </Li> </Ul> <Li> Chris Rock as Osmosis "Ozzy" Jones, an overzealous blue and white blood cell with little respect for authority . Since he was discredited, he was suspended for unnecessary force and placed in out - of - the - way patrols for making Frank throw up all over Mrs. Boyd in front of public after seeing a virus in the oyster to keep Frank healthy . Therefore, he seizes any opportunity to be able to make a difference . He is able to combine his eyes into one, to ooze through narrow spaces like cracks and under doors, and to contort his body . </Li> <Li> Laurence Fishburne as Thrax, a tall, extremely virulent, pathogenic agent . Thrax is referred to as "The Red Death" (a common nickname for the Ebola virus) but does not appear to cause an existing disease, although he claims loudly, "Ebola is a case of dandruff compared to me!", and has killed numerous people before arriving in Frank . He carries a chain consisting of numerous chromosomes removed from his other victims' hypothalamus as a trophy . His left index finger is a long claw that can cause instant inflammation . This lets him bypass the blood - brain barrier, alter the properties of other cells, or outright kill them . Although Thrax is a virus, his name appears to be a pun on "anthrax"; despite the fact that the anthrax microbe is the bacteria bacillus Bacillus_anthracis rather than a virus . </Li> <Li> David Hyde Pierce as Drixenol "Drix" Koldreliff, a stoic cold pill who becomes Ozzy's best friend . His right arm is a cannon used to shoot an assorted variety of medication, including one that freezes any target . He is a follower of written rules and compensates for his doubts of himself by acting haughtily . He is intelligent, clever, and dedicated to work . Straight - laced and by - the - book, he is in disagreement with the crude humor and unorthodox methods of Ozzy, but respects Ozzy as a partner due to his dedication to fighting diseases . </Li>

What disease was the bad guy in osmosis jones
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