<Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Fragile X syndrome (FXS) is a genetic disorder . Symptoms often include mild to moderate intellectual disability . Physical features may include a long and narrow face, large ears, flexible fingers, and large testicles . About a third of people have features of autism such as problems with social interactions and delayed speech . Hyperactivity is common and seizures occur in about 10% . Males are usually more affected than females . </P> <P> Fragile X syndrome is typically due to an expansion of the CGG triplet repeat within the Fragile X mental retardation 1 (FMR1) gene on the X chromosome . This results in not enough fragile X mental retardation protein (FMRP), which is required for normal development of the connection between neurons . Diagnosis is by genetic testing to determine the number of CGG repeats in the FMRI gene . Normal is between 5 and 40 repeats, fragile X syndrome occurs with more than 200, and a premutation is said to be present when a middle number of repeats occur . Testing for premutation carriers may allow for genetic counseling . </P> <P> There is no cure . Early intervention is recommended as it provides the most opportunity for developing a full range of skills . These interventions may include special education, speech therapy, physical therapy, or behavioral therapy . Medications may be used to treat associated seizures, mood problems, or ADHD . Fragile X syndrome occurs in about 1 in 4,000 males and 1 in 8,000 females . </P>

How did fragile x syndrome get its name