<Tr> <Th> Deaths </Th> <Td> 114,800 (2015) </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Sickle - cell disease (SCD) is a group of blood disorders typically inherited from a person's parents . The most common type is known as sickle - cell anaemia (SCA). It results in an abnormality in the oxygen - carrying protein haemoglobin (haemoglobin S) found in red blood cells . This leads to a rigid, sickle - like shape under certain circumstances . Problems in sickle cell disease typically begin around 5 to 6 months of age . A number of health problems may develop, such as attacks of pain ("sickle - cell crisis"), anemia, swelling in the hands and feet, bacterial infections, and stroke . Long term pain may develop as people get older . The average life expectancy in the developed world is 40 to 60 years . </P> <P> Sickle - cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent . This gene occurs in chromosome 11 . Several subtypes exist, depending on the exact mutation in each haemoglobin gene . An attack can be set off by temperature changes, stress, dehydration, and high altitude . A person with a single abnormal copy does not usually have symptoms and is said to have sickle - cell trait . Such people are also referred to as carriers . Diagnosis is by a blood test and some countries test all babies at birth for the disease . Diagnosis is also possible during pregnancy . </P>

What type of inheritance is associated with sickle cell anemia