<P> In the National Football League (NFL) and the American Football League (AFL), 130 different quarterbacks have passed for at least 400 yards in a single game: 309 times in the regular season and 20 more in the postseason . Sid Luckman was the first to pass for 400 yards, in 1943 . Drew Brees has recorded the most 400 - yard games, with 18 in total . Brees has also recorded the most 400 - yard postseason games, with 3, including 2 consecutive in a single postseason (unofficial 3 consecutive over two postseasons). Cam Newton is the only player to throw for 400 yards in his first career game, and the only rookie with two (coincidentally consecutive) 400 yard games . Don Strock is the only quarterback to have thrown for 400 yards in a game that he did not start . Kurt Warner and Tom Brady are the only two quarterbacks to have thrown a 400 - yard game in the Super Bowl, and Brady is the only quarterback to have thrown a 500 - yard game in the Super Bowl . </P> <P> There have been nine occurrences of a quarterback recording two consecutive 400 - yard games . There have been 13 games where two opposing quarterbacks collected 400 passing yards in the same game . There have been five single - days (September 21, 1986, January 1, 2012, October 26, 2014, October 18, 2015, and October 29, 2017) where three quarterbacks recorded 400 - yard games . There has been one NFL week (September 8--12, 2012) where four quarterbacks recorded 400 - yard games . </P>

Who has the most 400 yard passing games in the nfl