<Tr> <Td> ← Previous "I Feel Good" </Td> <Td> Next →--</Td> </Tr> <Tr> <Td_colspan="2"> ER (season 15) List of ER episodes </Td> </Tr> <P> "And in the End ..." is the 331st and final episode of the American television series ER . The two - hour episode aired on April 2, 2009 and was preceded by a one - hour retrospective special . </P> <P> Dr. Tony Gates (John Stamos) treats a teenage girl in a coma with alcohol poisoning after she played drinking games with her friends . Gates calls the police when he discovers that the parents of the girl's friend supplied the alcohol, and has the friend's father arrested . Later, the girl's parents arrive and request she be transferred to Mercy Hospital . Before she can be transferred, the girl finally awakens but just thrashes around and is sent for a new CT to diagnose possible brain damage . </P>

What was the very last episode of er