<P> Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases: thrombin, FIXa, FXa, FXIa, and FXIIa . It is constantly active, but its adhesion to these factors is increased by the presence of heparan sulfate (a glycosaminoglycan) or the administration of heparins (different heparinoids increase affinity to FXa, thrombin, or both). Quantitative or qualitative deficiency of antithrombin (inborn or acquired, e.g., in proteinuria) leads to thrombophilia . </P> <P> Tissue factor pathway inhibitor (TFPI) limits the action of tissue factor (TF). It also inhibits excessive TF - mediated activation of FVII and FX . </P> <P> Plasmin is generated by proteolytic cleavage of plasminogen, a plasma protein synthesized in the liver . This cleavage is catalyzed by tissue plasminogen activator (t - PA), which is synthesized and secreted by endothelium . Plasmin proteolytically cleaves fibrin into fibrin degradation products that inhibit excessive fibrin formation . </P> <P> Prostacyclin (PGI) is released by endothelium and activates platelet G protein - linked receptors . This, in turn, activates adenylyl cyclase, which synthesizes cAMP . cAMP inhibits platelet activation by decreasing cytosolic levels of calcium and, by doing so, inhibits the release of granules that would lead to activation of additional platelets and the coagulation cascade . </P>

Which of the following is a correct sequence in the clotting cascade