<P> I - 65 also has interchanges with I - 265, I - 264, and a complex junction with I - 64 and I - 71 along the south bank of the Ohio River in central Louisville . From there, northbound motorists on I - 65 cross into Indiana on the Abraham Lincoln Bridge, while southbound I - 65 traffic enters Kentucky from Jeffersonville, Indiana via the John F. Kennedy Memorial Bridge . </P> <P> The widest stretch of I - 65 in its entirety is in Louisville, at Kentucky Route 1065 (Outer Loop) where the mainline is 14 lanes wide . </P> <P> The highway crosses between the Central and Eastern time zones at the border of Hart and LaRue counties, respectively . </P> <P> For most of 2016, the Ohio River Bridges Project routed all I - 65 traffic onto the Abraham Lincoln Bridge (a six - lane cable - stayed bridge now carrying only northbound traffic) while rebuilding the deck of the 1963 John F. Kennedy Memorial Bridge to accommodate six lanes of all - southbound traffic . The project is also completing the rebuild of the Kennedy Interchange just south of both bridges in downtown Louisville . On December 30, 2016, both I - 65 bridges began using electronic toll collection (ETC) to charge motorists for their use of this previously toll - free Interstate crossing . </P>

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