<P> One study found that the majority of capillaries in cherry hemangiomas are fenestrated because of staining for carbonic anhydrase activity . </P> <P> Cherry angiomas appear spontaneously in many people in middle age but can also, less commonly, occur in young people . They can also occur in an aggressive eruptive manner in any age . The underlying cause for the development of cherry angiomas is not understood . </P> <P> Findings suggest that cherry angioma may occur through two different mechanisms: angiogenesis (the formation of new blood vessels from pre-existing vessels), and vasculogenesis (the formation of totally new vessels, which usually occurs during embryonic and fetal development). </P> <P> The first study trying to bring light to the molecular and genetic mechanisms behind cherry / senile hemangioma was published in 2010 . The study found that the level of microRNA 424 is significantly reduced in senile hemangiomas compared to normal skin resulting in increased protein expression of MEK1 and cyclin E1 . By inhibiting mir - 424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which, important for the development of senile hemangioma, induced cell proliferation of the endothelial cells . They also found that targeting MEK1 and cyclin E1 with small interfering RNA decreased the number of endothelial cells . </P>

What causes red blood filled spots on skin