<P> Intestinal glands are found in the epithelia of the small intestine, namely the duodenum, jejunum, and ileum, and in the large intestine (colon), where they are sometimes called colonic crypts . Intestinal glands of the small intestine contain a base of replicating stem cells, Paneth cells of the innate immune system, and goblet cells, which produce mucus . In the colon, crypts do not have Paneth cells . </P> <P> The enterocytes in the small intestinal mucosa contain digestive enzymes that digest specific foods while they are being absorbed through the epithelium . These enzymes include peptidase, sucrase, maltase, lactase and intestinal lipase . This is in contrast to the gastric glands of the stomach where chief cells secrete pepsinogen . </P> <P> Also, new epithelium is formed here, which is important because the cells at this site are continuously worn away by the passing food . The basal (further from the intestinal lumen) portion of the crypt contains multipotent stem cells . During each mitosis, one of the two daughter cells remains in the crypt as a stem cell, while the other differentiates and migrates up the side of the crypt and eventually into the villus . Goblet cells are among the cells produced in this fashion . Many genes have been shown to be important for the differentiation of intestinal stem cells . </P> <P> Loss of proliferation control in the crypts is thought to lead to colorectal cancer . </P>

Where are stem cells of the small intestine located
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