<Li> Paul Rodriguez as Crazy Carlito (cameo), the mad bomber </Li> <Li> Kiernan Shipka as a young girl who makes a cameo appearance when Diggs, Butch, Catherine, and Seamus are in the park . She is scared away by Seamus talking in front of her . She reappears on the ferry and at the fairground (both instances seeing Duncan talking and Kitty pleading for help respectively). </Li> <Li> Betty Phillips as Cat Lady </Li> <Ul> <Li> James Marsden as Diggs, an arrogant, dimwitted, rebellious, impulsive, and egotistical German Shepherd who becomes an agent of D.O.G. </Li> <Li> Nick Nolte as Butch, a gruff - voiced Anatolian Shepherd dog . Nolte replaced Alec Baldwin in this movie . </Li> <Li> Christina Applegate as Catherine (Agent 47 at M.E.O.W.S.), a female Russian Blue cat, who becomes Diggs' partner . </Li> <Li> Katt Williams as Seamus, a dim - witted, clumsy carrier pigeon . </Li> <Li> Bette Midler as Kitty Galore, a Sphynx cat, formerly a M.E.O.W.S. agent named Ivana Clawyu . </Li> <Li> Neil Patrick Harris as Lou, who is now an adult beagle and the head official of D.O.G. HQ . Harris replaced Tobey Maguire in this movie . </Li> <Li> Sean Hayes as Mr. Tinkles, a Persian who is detained on Alcatraz Island . </Li> <Li> Wallace Shawn as Calico, an Exotic Shorthair who works for Mr. Tinkles . Wallace Shawn replaced Jon Lovitz in this movie . </Li> <Li> Roger Moore as Tab Lazenby, the head of M.E.O.W.S. HQ </Li> <Li> Joe Pantoliano as Peek, a Chinese Crested . He is the tech specialist and head of Covert Ops at D.O.G. HQ . </Li> <Li> Michael Clarke Duncan as Sam, an Old English Sheepdog . </Li> <Li> Elizabeth Daily as Scrumptious, Kitty's pet albino mouse . She also voices one of Catherine's nieces and Patches . </Li> <Li> Phil LaMarr as Paws, a robotic Maine Coon with metal teeth who works for Kitty . </Li> <Li> J.K. Simmons as Gruff K - 9 </Li> <Li> Carlos Alazraqui as Cat Gunner </Li> <Li> Michael Beattie as Angus MacDougall </Li> <Li> Jeff Bennett as Duncan MacDougall </Li> <Li> Bonnie Cahoon as Dog PA </Li> <Li> Grey DeLisle as Security English Bulldog / Catherine's niece / Cat Spy Anaylst </Li> <Li> Roger Jackson as Fat Cat Inmate </Li> <Li> Bumper Robinson as Cool Cat / Dog Killa / Slim </Li> <Li> André Sogliuzzo as Snobby K - 9 </Li> <Li> Rick D. Wasserman as Rocky </Li> <Li> Karen Strassman as French Poodle (uncredited) </Li> </Ul>

Cats and dogs the revenge of kitty galore catherine