<Tr> <Th> Frequency </Th> <Td> 5--10% </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels through the wrist at the carpal tunnel . The main symptoms are pain, numbness, and tingling, in the thumb, index finger, middle finger, and the thumb side of the ring fingers . Symptoms typically start gradually and during the night . Pain may extend up the arm . Weak grip strength may occur and after a long period of time the muscles at the base of the thumb may waste away . In more than half of cases both sides are affected . </P> <P> Risk factors include obesity, repetitive wrist work, pregnancy, and rheumatoid arthritis . There is tentative evidence that hypothyroidism increases the risk . Diabetes mellitus is weakly associated with CTS . The use of birth control pills does not affect the risk . Types of work that are associated include computer work, work with vibrating tools, and work that requires a strong grip . Diagnosis is suspected based on signs, symptoms, and specific physical tests and may be confirmed with electrodiagnostic tests . If muscle wasting at the base of the thumb is present, the diagnosis is likely . </P>

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