<P> The most severe cases of dysplasia are referred to as "carcinoma in situ ." In Latin, the term "in situ" means "in place", so carcinoma in situ refers to an uncontrolled growth of cells that remains in the original location and has not shown invasion into other tissues . Nevertheless, carcinoma in situ may develop into an invasive malignancy and is usually removed surgically, if possible . </P> <P> Just like a population of animals undergoes evolution, an unchecked population of cells also can undergo evolution . This undesirable process is called somatic evolution, and is how cancer arises and becomes more malignant . </P> <P> Most changes in cellular metabolism that allow cells to grow in a disorderly fashion lead to cell death . However once cancer begins, cancer cells undergo a process of natural selection: the few cells with new genetic changes that enhance their survival or reproduction continue to multiply, and soon come to dominate the growing tumor, as cells with less favorable genetic change are out - competed . This is exactly how pathogens such as MRSA can become antibiotic - resistant (or how HIV can become drug - resistant), and the same reason why crop blights and pests can become pesticide - resistant . This evolution is why cancer recurrences will have cells that have acquired cancer - drug resistance (or in some cases, resistance to radiation from radiotherapy). </P> <P> In a 2000 article by Hanahan and Weinberg, the biological properties of malignant tumor cells were summarized as follows: </P>

Which term refers to changes in a microbial dna sequence by way of rare replication mistakes