<P> S. pyogenes can also cause disease in the form of post-infectious "non-pyogenic" (not associated with local bacterial multiplication and pus formation) syndromes . These autoimmune - mediated complications follow a small percentage of infections and include rheumatic fever and acute post-infectious glomerulonephritis . Both conditions appear several weeks following the initial streptococcal infection . Rheumatic fever is characterized by inflammation of the joints and / or heart following an episode of streptococcal pharyngitis . Acute glomerulonephritis, inflammation of the renal glomerulus, can follow streptococcal pharyngitis or skin infection . </P> <P> This bacterium remains acutely sensitive to penicillin . Failure of treatment with penicillin is generally attributed to other local commensal organisms producing β - lactamase, or failure to achieve adequate tissue levels in the pharynx . Certain strains have developed resistance to macrolides, tetracyclines, and clindamycin . </P> <P> Many S. pyogenes proteins have unique properties, which have been harnessed in recent years to produce a highly specific "superglue" and a route to enhance the effectiveness of antibody therapy . </P> <P> The CRISPR system from this organism that is used to recognize and destroy DNA from invading viruses, stopping the infection, was appropriated in 2012 for use as a genome - editing tool that could potentially alter any piece of DNA and later RNA . </P>

Streptococcus pyogenes causes which of the following diseases