<Li> Using a counterfactual consideration as the basis for applying each criterion . </Li> <Li> Subdividing them into three categories: direct, mechanistic and parallel evidence, expected to complement each other . This operational reformulation of the criteria has been recently proposed in the context of evidence - based medicine . </Li> <Li> Considering confounding factors and bias . </Li> <Li> Using Hill's criteria as a guide, but not considering them to give definitive conclusions . </Li>

Which of the following is not an important consideration for assessing causality