<Tr> <Th> Family </Th> <Td> John House (legal father, deceased) Blythe House (mother) </Td> </Tr> <Tr> <Th> Significant other (s) </Th> <Td> Stacy Warner (ex-girlfriend prior to series) Lisa Cuddy (ex-girlfriend) Dominika Petrova (ex-wife) </Td> </Tr> <P> Gregory House, M.D., commonly referred to by his surname House, is the title character of the American medical drama series House . Created by David Shore and portrayed by English actor Hugh Laurie, he leads a team of diagnosticians as the Head of Diagnostic Medicine at the fictional Princeton - Plainsboro Teaching Hospital in Princeton, New Jersey (based on the real - life Yale--New Haven Hospital in New Haven, Connecticut). </P> <P> House's character has been described as a misanthrope, cynic, narcissist, and curmudgeon, the last of which was named one of the top television words of 2005 in honor of the character . He is the only character to appear in all 177 episodes and, except for Wilson's brief appearance, is the only regular character to appear in the season six premiere . </P>

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