<P> In this context, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area . One manifestation of myxedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves disease, an autoimmune form of hyperthyroidism . Myxedema can also occur in Hashimoto's thyroiditis and other long - standing forms of hypothyroidism . </P> <P> The word myxedema originates from μύξα, taken from ancient Greek to convey' mucus' or' slimy substance', and ὁοίδημα for "swelling". It can also be thought as nonpitting edema, in contrast to pitting edema . </P> <P> Myxedema can occur in the lower leg (pretibial myxedema) and behind the eyes (exophthalmos). </P> <P> Myxedema is known to occur in various forms of hypothyroidism, and also in Graves' disease . One of the hallmarks of Grave's disease is pretibial myxedema, myxedema of the lower limb . </P>

What are the signs and symptoms of myxedema