<P> CRP is synthesized by the liver in response to factors released by macrophages and fat cells (adipocytes). It is a member of the pentraxin family of proteins . It is not related to C - peptide (insulin) or protein C (blood coagulation). C - reactive protein was the first pattern recognition receptor (PRR) to be identified . </P> <P> Discovered by Tillett and Francis in 1930, it was initially thought that CRP might be a pathogenic secretion since it was elevated in a variety of illnesses, including cancer . The later discovery of hepatic synthesis demonstrated that it is a native protein . Intially, CRP was measured using Quellung reaction which gave a positive or a negative reaction . More precise methods nowadays is using dynamic light scattering on antibodies specific to CRP . </P> <P> CRP was so named because it was first identified as a substance in the serum of patients with acute inflammation that reacted with the somatic' C' carbohydrate antigen of the capsule of pneumococcus . </P> <P> The CRP gene is located on chromosome 1 (1q23. 2). It is a member of the small pentraxins family . It has 224 amino acids, has a monomer molecular mass of 25,106 Da, and has an annular pentameric discoid shape . </P>

What does the c stand for in crp
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