<P> The rogues gallery of Spider - Man has garnered many positive reviews and has been considered as one of the greatest rogues gallery of all time by many alongside Batman's rogues gallery . </P> <P> The majority of supervillains depicted in Spider - Man comics first appeared in The Amazing Spider - Man while some first appeared in later spinoff comics such as The Spectacular Spider - Man and Marvel Team - Up and other titles . </P> <P> Most of the supervillains of Spider - Man would be introduced in The Amazing Spider - Man comic book starting with the Chameleon . The early villains would be introduced in the 1960s in the Silver Age of Comic Books . Originally created by Stan Lee and Steve Ditko . John Romita, Sr. would soon replace Ditko starting with the Rhino . Gerry Conway later replaced Stan Lee and helped create new adversaries for the web - slinger and also helped pave the way to the Bronze Age of Comic Books with depicting Green Goblin as the killer of Spider - Man's long time romantic interest, Gwen Stacy . Many collaborators would soon take over The Amazing Spider - Man title . One of the more popular examples included Todd McFarlane's Venom in the Modern Age of Comic Books . Note: Alter ego characters who are the most high profile in the supervillain alias but others have shared that supervillain name are in bold . Alter egos listed having N / A use their real name as the supervillain name . In chronological order . </P> <Table> <Tr> <Td> Supervillain name </Td> <Td> Notable alter ego </Td> <Td> First appearance issue #</Td> <Td> Creator </Td> </Tr> <Tr> <Td> Chameleon </Td> <Td> Dmitri Anatoly Nikolayevich </Td> <Td> #1 (March 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Vulture </Td> <Td> Adrian Toomes Blackie Drago </Td> <Td> #2 (May 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Tinkerer </Td> <Td> Phineas Mason </Td> <Td> #2 (May 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Doctor Octopus </Td> <Td> Doctor Otto Gunther Octavius </Td> <Td> #3 (July 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Sandman </Td> <Td> William Baker / Flint Marko </Td> <Td> #4 (September 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Lizard </Td> <Td> Doctor Curt Connors </Td> <Td> #6 (November 1963) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Living Brain </Td> <Td> N / A </Td> <Td> #8 (January 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Electro </Td> <Td> Maxwell Dillon </Td> <Td> #9 (February 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Big Man </Td> <Td> Frederick Foswell Janice Foswell </Td> <Td> #10 (March 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Mysterio </Td> <Td> Quentin Beck </Td> <Td> #13 (June 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Green Goblin </Td> <Td> Norman Osborn Harry Osborn </Td> <Td> #14 (July 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Kraven the Hunter </Td> <Td> Sergei Kravinoff Alyosha Kravinoff (son) Ana Kravinoff (daughter) </Td> <Td> #15 (August 1964) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Scorpion </Td> <Td> Mac Gargan </Td> <Td> #20 (January 1965) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Spencer Smythe / Spider - Slayers </Td> <Td> <Ul> <Li> Spencer Smythe: N / A </Li> <Li> Spider - Slayer: Multiple names </Li> </Ul> </Td> <Td> #25 (June 1965) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Crime Master </Td> <Td> Various </Td> <Td> #26 (July 1965) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Molten Man </Td> <Td> Mark Raxton </Td> <Td> #28 (September 1965) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Looter </Td> <Td> Norton G. Fester </Td> <Td> #36 (May 1966) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Robot Master / Gaunt </Td> <Td> Mendel Stromm </Td> <Td> #37 (June 1966) </Td> <Td> Stan Lee Steve Ditko </Td> </Tr> <Tr> <Td> Rhino </Td> <Td> Aleksei Mikhailovich Sytsevich </Td> <Td> #41 (October 1966) </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> Shocker </Td> <Td> Herman Schultz </Td> <Td> #46 (March 1967) </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> Kingpin </Td> <Td> Wilson Fisk </Td> <Td> #50 (July 1967) ("Spider - Man No More!") </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> The Finisher </Td> <Td> Karl Fiers </Td> <Td> Annual #5 (November 1968) </Td> <Td> Stan Lee Larry Lieber </Td> </Tr> <Tr> <Td> Man Mountain Marko </Td> <Td> Michael Marko </Td> <Td> #73 (June 1969) </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> Silvermane </Td> <Td> Silvio Manfredi </Td> <Td> #73 (June 1969) </Td> <Td> Stan Lee John Buscema </Td> </Tr> <Tr> <Td> Kangaroo </Td> <Td> Frank Oliver Brian Hibbs </Td> <Td> #81 (February 1980) </Td> <Td> Stan Lee John Buscama Jim Mooney John Romita, Sr . </Td> </Tr> <Tr> <Td> Schemer </Td> <Td> Richard Fisk </Td> <Td> #83 (April 1983) </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> Morbius </Td> <Td> Michael Morbius </Td> <Td> #101 (January 1971) </Td> <Td> Roy Thomas Gil Kane </Td> </Tr> <Tr> <Td> Gog </Td> <Td> N / A </Td> <Td> #103 (December 1973) </Td> <Td> Roy Thomas Gil Kane </Td> </Tr> <Tr> <Td> Gibbon </Td> <Td> Martin Blank </Td> <Td> #110 (July 1972) </Td> <Td> Stan Lee John Romita, Sr . </Td> </Tr> <Tr> <Td> Hammerhead </Td> <Td> Joseph (full name unknown) </Td> <Td> #113 (October 10, 1972) </Td> <Td> Gerry Conway John Romita, Sr . </Td> </Tr> <Tr> <Td> Man - Wolf </Td> <Td> John Jameson </Td> <Td> #124 (September 1973). </Td> <Td> Gerry Conway </Td> </Tr> <Tr> <Td> Jackal </Td> <Td> Miles Warren </Td> <Td> #129 (February 1974) </Td> <Td> Gerry Conway Ross Andru </Td> </Tr> <Tr> <Td> Tarantula </Td> <Td> Various </Td> <Td> #134 (July 1974) </Td> <Td> Gerry Conway Ross Andru </Td> </Tr> <Tr> <Td> Mindworm </Td> <Td> William Turner </Td> <Td> #138 (November 1974) </Td> <Td> Gerry Conway Ross Andru </Td> </Tr> <Tr> <Td> Grizzly </Td> <Td> Maxwell Markham </Td> <Td> #139 (December 1974) </Td> <Td> Gerry Conway Ross Andru </Td> </Tr> <Tr> <Td> Human Fly </Td> <Td> Richard Deacon </Td> <Td> Annual #10 (1976) </Td> <Td> Len Wein Bill Mantlo Gil Kane </Td> </Tr> <Tr> <Td> Will o' the Wisp </Td> <Td> Jackson Arvad </Td> <Td> #167 (April 1977) </Td> <Td> Len Wein Ross Andru </Td> </Tr> <Tr> <Td> Big Wheel </Td> <Td> Jackson Wheele </Td> <Td> #182 (July 1978) </Td> <Td> Marv Wolfman Ross Andru Mike Esposito </Td> </Tr> <Tr> <Td> Black Cat </Td> <Td> Felicia Hardy </Td> <Td> #194 (July 1979) </Td> <Td> Marv Wolfman Keith Pollard </Td> </Tr> <Tr> <Td> Calypso </Td> <Td> Calypso Ezili </Td> <Td> #209 (October 1980) </Td> <Td> Dennis O'Neil Alan Weiss </Td> </Tr> <Tr> <Td> Hydro - Man </Td> <Td> Morris Bench </Td> <Td> #212 (January 10, 1981) </Td> <Td> Denny O'Neil John Romita, Jr . </Td> </Tr> <Tr> <Td> Hobgoblin </Td> <Td> Roderick Kingsley Jason Macendale Phil Urich </Td> <Td> #238 (March 1983) </Td> <Td> Roger Stern John Romita Sr . </Td> </Tr> <Tr> <Td> Rose </Td> <Td> Richard Fisk </Td> <Td> #253 (June 1984) </Td> <Td> Tom DeFalco </Td> </Tr> <Tr> <Td> Alistair Smythe </Td> <Td> N / A </Td> <Td> Annual #19 (November 1985) </Td> <Td> Louise Simonson Mary Wilshire </Td> </Tr> <Tr> <Td> Slyde </Td> <Td> Jalome Beacher </Td> <Td> #272 (January 1986) </Td> <Td> Tom DeFalco Sal Buscema </Td> </Tr> <Tr> <Td> Venom </Td> <Td> Eddie Brock Mac Gargan </Td> <Td> #300 </Td> <Td> Todd McFarlane </Td> </Tr> <Tr> <Td> Styx and Stone </Td> <Td> Jacob Eishorn and Gerald Stone </Td> <Td> #309 (November 1988) </Td> <Td> David Michelinie Todd McFarlane </Td> </Tr> <Tr> <Td> Carnage </Td> <Td> Cletus Kasady </Td> <Td> #361 (April 1992) </Td> <Td> David Michelinie Erik Larsen Mark Bagley </Td> </Tr> <Tr> <Td> Black Tarantula </Td> <Td> Carlos LaMuerto </Td> <Td> #419 (January 1997) </Td> <Td> Tom DeFalco Steve Skroce </Td> </Tr> <Tr> <Td> Morlun </Td> <Td> N / A </Td> <Td> vol. 2 #30 (June 2001) </Td> <Td> J. Michael Straczynski John Romita, Jr . </Td> </Tr> <Tr> <Td> Shathra </Td> <Td> N / A </Td> <Td> vol. 2 #46 (December 2006 </Td> <Td> J. Michael Straczynski John Romita, Jr . Scott Hanna </Td> </Tr> <Tr> <Td> Grey Goblin </Td> <Td> Gabriel Stacy Lily Hollister (Menace) </Td> <Td> #509 (August 2004) #550 (April 2008) (Menace) </Td> <Td> J. Michael Straczynski Mike Deodato </Td> </Tr> <Tr> <Td> Mister Negative </Td> <Td> Martin Li </Td> <Td> #546 (January 2008) (full appearance) </Td> <Td> Dan Slott Phil Jimenez </Td> </Tr> <Tr> <Td> Overdrive </Td> <Td> N / A </Td> <Td> Swing Shift (May 2007) </Td> <Td> Dan Slott Phil Jimenez </Td> </Tr> <Tr> <Td> Massacre </Td> <Td> Marcus Lyman </Td> <Td> #655 (April 2011) </Td> <Td> Dan Slott Marcos Martín </Td> </Tr> </Table>

Who was the first villain spiderman ever fought