<P> The precursor for fatty acids is acetyl coA and it occurs in the cytosol of the cell . The overall net reaction, using palmitate (16: 0) as a model substrate is: </P> <P> 8 Acetyl - coA + 7 ATP + 14 NADH + 6H+ → palmitate + 14 NADP+ + 6H2O + 7ADP + 7P ¡ </P> <P> Cholesterol can be made from acetyl - CoA through a multiple - step pathway known as Isoprenoid Pathway . Cholesterols are essential because they can be modified to form different hormones in the body such as progesteron 70% of Choleserol biosynthesis occurs in the cytosol of liver cells . </P> <P> Lipid Metabolism Disorders are illnesses where trouble occurs in breaking down or synthesizing fats (or fat - like substances). Lipid metabolism disorders are associated with an increase in the concentrations of plasma lipids in the blood such as LDL cholesterol, VLDL, and triglycerides which most commonly lead to cardiovascular diseases . A good deal of the time these disorders are hereditary, meaning it's a condition that is passed along from parent to child through their genes . Gaucher's Disease (Type I, Type II, and Type III), Neimann - Pick Disease, Tay - Sachs Disease, and Fabry's Disease are all diseases where those afflicted can have a disorder of their body's lipid metabolism . Rarer diseases concerning a disorder of the lipid metabolism are Sitosterolemia, Wolman's Disease, Refsum's Disease, and Cerebrotendinous Xanthomatosis . </P>

Where does lipid synthesis occur in a cell