<P> Wheaton, LeVar Burton, Leonard Nimoy, Brent Spiner, and George Takei have all appeared on the show, making the Star Trek franchise the most represented franchise on the show in terms of guest appearances . </P> <P> Mrs. Debbie Malvina Wolowitz (voiced by Carol Ann Susi) is Howard's over-protective, controlling, belittling, but loving and caring stereotypical Jewish mother . The character is not shown on - screen with the exception of one episode in season six in which her body, but not face is briefly shown . Mrs. Wolowitz's raspy voice is heard usually in scenes at her house, which she shares with Howard . She talks to Howard always by yelling at him from another room, which results in awkward conversations with Howard yelling back at her . In a flashback, when the guys hear her yelling in a masculine voice, they ask Howard if that was his father, to which Howard replies, "If she grows any more hair on her face, yes". </P> <P> Mrs. Wolowitz is also described as being enormously obese and wearing a wig and painted - on eyebrows . She seems to be oblivious to Howard's work as an engineer and treats him as though he is still a child . She is aa master at jeopardy and guessing answers at game shows . She frequently refers to Leonard, Sheldon, and Raj as Howard's "little friends" (as in, "I made some cookies and Hawaiian Punch for you and your little friends!") and often refers to Caltech as a "school". Howard often makes references to his mother as being a "crazy old lady", but deep down, he is deeply attached to his mother and quite happy to be treated like a child . However, in one episode, Howard attempts to move out after a fight with his mother, but has serious delusions that she is trying to force him to stay, when in actuality, she is urging him to move out, which leads to him staying . She is also noted to be on hormone replacement therapy, and she wants to "play doctor" with Raj when he asks to sleep over . </P> <P> When Howard reveals that he has proposed to Bernadette and she has accepted, she collapses, causing Howard to panic and dislocate his shoulder while trying to barge into the bathroom to help her . The timing leads him to believe that she may not like Bernadette (who is Catholic) and has suffered a heart attack from the shock of the news . In actuality, her fainting was due to food poisoning from the food she ate while meeting Bernadette and was completely unrelated to Howard's news . She has graciously accepted Bernadette as her daughter - in - law and is impressed by Bernadette's doctorate . </P>

Where did big bang theory characters go to college