<P> Diethylaminoethyl cellulose (DEAE - C) is a positively charged resin used in ion - exchange chromatography, a type of column chromatography, for the separation and purification of proteins and nucleic acids . Gel matrix beads are derivatized with diethylaminoethanol (DEAE) and lock negatively charged proteins or nucleic acids into the matrix . The proteins are released from the resin by increasing the salt concentration of the solvent or changing the pH of the solution as to change the charge on the protein . </P> <P> DEAE - C is commonly commercially available as DE52 and DE53 . These resins are prepared preswollen although cellulose exchangers swell in a strong basic environment to increase access to binding sites . </P>

Deae cellulose or cm cellulose are only effective in the ph range of