<P> Malignant transformation of B cells and their precursors can cause a host of cancers, including chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), hairy cell leukemia, follicular lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, and plasma cell malignancies such as multiple myeloma, Waldenström's macroglobulinemia, and certain forms of amyloidosis . </P> <P> A study that investigated the methylome of B cells along their differentiation cycle, using whole - genome bisulfite sequencing (WGBS), showed that there is a hypomethylation from the earliest stages to the most differentiated stages . The largest methylation difference is between the stages of germinal center B cells and memory B cells . Furthermore, this study showed that there is a similarity between B cell tumors and long - lived B cells in their DNA methylation signatures . </P>

Describe the interaction between the b cell and helper t cell