<P> If defined strictly as having local effect, the topical route of administration can also include enteral administration of medications that are poorly absorbable by the gastrointestinal tract . One poorly absorbable antibiotic is vancomycin, which is recommended by mouth as a treatment for severe Clostridium difficile colitis . </P> <P> The reason for choice of routes of drug administration are governing by various factors: </P> <Ul> <Li> Physical and chemical properties of the drug . The physical properties are solid, liquid and gas . The chemical properties are solubility, stability, pH, irritancy etc . </Li> <Li> Site of desired action: the action may be localised and approachable or generalised and not approachable . </Li> <Li> Rate of extent of absorption of the drug from different routes . </Li> <Li> Effect of digestive juices and the first phase of metabolism . </Li> <Li> Condition of the patient . </Li> </Ul> <Li> Physical and chemical properties of the drug . The physical properties are solid, liquid and gas . The chemical properties are solubility, stability, pH, irritancy etc . </Li>

Factors affecting choice of route of drug administration
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