<P> As suggested by its specific epithet reclusa (recluse), the brown recluse spider is rarely aggressive, and bites from the species are uncommon . In 2001, more than 2,000 brown recluse spiders were removed from a heavily infested home in Kansas, yet the four residents who had lived there for years were never harmed by the spiders, despite many encounters with them . The spider usually bites only when pressed against the skin, such as when tangled within clothes, towels, bedding, inside work gloves, etc . Many human victims report having been bitten after putting on clothes that had not been worn recently, or had been left for many days undisturbed on the floor . The fangs of the brown recluse are not large enough to penetrate most fabric . </P> <P> When both types of loxoscelism do result, systemic effects may occur before necrosis, as the venom spreads throughout the body in minutes . Children, the elderly, and the debilitatingly ill may be more susceptible to systemic loxoscelism . The systemic symptoms most commonly experienced include nausea, vomiting, fever, rashes, and muscle and joint pain . Rarely, such bites can result in hemolysis, thrombocytopenia, disseminated intravascular coagulation, organ damage, and even death . Most fatalities are in children under the age of seven or those with a weak immune system . </P> <P> While the majority of brown recluse spider bites do not result in any symptoms, cutaneous symptoms occur more frequently than systemic symptoms . In such instances, the bite forms a necrotizing ulcer as the result of soft tissue destruction and may take months to heal, leaving deep scars . These bites usually become painful and itchy within 2 to 8 hours . Pain and other local effects worsen 12 to 36 hours after the bite, and the necrosis develops over the next few days . Over time, the wound may grow to as large as 25 cm (10 inches). The damaged tissue becomes gangrenous and eventually sloughs away . </P> <P> There is now an ELISA - based test for brown recluse venom that can determine whether a wound is a brown recluse bite, although it is not commercially available and not in routine clinical use . Clinical diagnoses often use Occam's razor principle in diagnosing bites based on what spiders the patient likely encountered and previous similar diagnoses . </P>

What does a brown lecluse spider bite look like
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