<P> The List of popes from the Medici family includes four men from the late - 15th century through the early - 17th century . The Medici family, also known as the House of Medici, first attained wealth and political power in Florence in the 13th century through its success in commerce and banking . They were closely associated with the Renaissance and cultural and artistic revival during this period . </P> <P> The Medici were a powerful and influential Florentine family from the 13th to 17th century . There were four popes who were related to the Medici and each other . </P> <Ul> <Li> Pope Leo X (December 11, 1475--December 1, 1521), born Giovanni de' Medici, was pope from 1513 to his death . </Li> <Li> Pope Clement VII (May 26, 1478--September 25, 1534), born Giulio di Giuliano de' Medici, was a cardinal from 1513 to 1523 and was pope from 1523 to 1534 . </Li> <Li> Pope Pius IV (31 March 1499--December 9, 1565), born Giovanni Angelo Medici, was pope from 1559 to 1565 . However, he was only distantly related to the other Medici Popes . </Li> <Li> Pope Leo XI (June 2, 1535--April 27, 1605), born Alessandro Ottaviano de' Medici, was pope from April 1, 1605, to April 27 of the same year . </Li> </Ul>

How many popes did the medici family produce