<P> In hypoglycemia caused by excessive insulin, liver glycogen levels are high, but the high insulin levels prevent the glycogenolysis necessary to maintain normal blood sugar levels . Glucagon is a common treatment for this type of hypoglycemia . </P> <P> Various inborn errors of metabolism are caused by deficiencies of enzymes necessary for glycogen synthesis or breakdown . These are collectively referred to as glycogen storage diseases . </P> <P> Long - distance athletes, such as marathon runners, cross-country skiers, and cyclists, often experience glycogen depletion, where almost all of the athlete's glycogen stores are depleted after long periods of exertion without sufficient carbohydrate consumption . This phenomenon is referred to as "hitting the wall". </P> <P> Glycogen depletion can be forestalled in three possible ways . First, during exercise, carbohydrates with the highest possible rate of conversion to blood glucose (high glycemic index) are ingested continuously . The best possible outcome of this strategy replaces about 35% of glucose consumed at heart rates above about 80% of maximum . Second, through endurance training adaptations and specialized regimens (e.g. fasting low - intensity endurance training), the body can condition type I muscle fibers to improve both fuel use efficiency and workload capacity to increase the percentage of fatty acids used as fuel, sparing carbohydrate use from all sources . Third, by consuming large quantities of carbohydrates after depleting glycogen stores as a result of exercise or diet, the body can increase storage capacity of intramuscular glycogen stores . This process is known as carbohydrate loading . In general, glycemic index of carbohydrate source does not matter since muscular insulin sensitivity is increased as a result of temporary glycogen depletion . </P>

When does the body experience the highest rate of glycogen storage