<P> First proposed in 1965 by Ronald Melzack and Patrick Wall, the theory offers a physiological explanation for the previously observed effect of psychology on pain perception . Combining early concepts derived from the specificity theory and the peripheral pattern theory, the gate control theory is considered to be one of the most influential theories of pain because it provided a neural basis which reconciled the specificity and pattern theories and ultimately revolutionized pain research . </P> <P> Although there are some important observations which the gate control theory cannot explain adequately, it remains the theory of pain that most accurately accounts for the physical and psychological aspects of pain perception . </P> <P> Willem Noordenbos (1910--1990), a Dutch researcher at the University of Amsterdam, was the first one to propose a model with an interaction between small (unmyelinated) and thick (myelinated) fibers in 1959 . The fast (myelinated) fibers block the slow (unmyelinated) fibers, "fast blocks slow". </P> <P> Ronald Melzack and Patrick Wall introduced their "gate control" theory of pain in the 1965 Science article "Pain Mechanisms: A New Theory". The authors proposed that both thin (pain) and large diameter (touch, pressure, vibration) nerve fibers carry information from the site of injury to two destinations in the dorsal horn of the spinal cord: transmission cells that carry the pain signal up to the brain, and inhibitory interneurons that impede transmission cell activity . Activity in both thin and large diameter fibers excites transmission cells . Thin fiber activity impedes the inhibitory cells (tending to allow the transmission cell to fire) and large diameter fiber activity excites the inhibitory cells (tending to inhibit transmission cell activity). So, the more large fiber (touch, pressure, vibration) activity relative to thin fiber activity at the inhibitory cell, the less pain is felt . The authors had drawn a neural "circuit diagram" to explain why we rub a smack . They pictured not only a signal traveling from the site of injury to the inhibitory and transmission cells and up the spinal cord to the brain, but also a signal traveling from the site of injury directly up the cord to the brain (bypassing the inhibitory and transmission cells) where, depending on the state of the brain, it may trigger a signal back down the spinal cord to modulate inhibitory cell activity (and so pain intensity). The theory offered a physiological explanation for the previously observed effect of psychology on pain perception . </P>

Where is the gate located that is referred to in the gate control theory of pain