<Li> Reactions are non-synthetic in nature and in general produce a more water - soluble and less active metabolites . </Li> <Li> The majority of metabolites are generated by a common hydroxylating enzyme system known as Cytochrome P450 . </Li> <Ul> <Li> These reactions involve covalent attachment of small polar endogenous molecule such as glucuronic acid, sulfate, or glycine to form water - soluble compounds . </Li> <Li> This is also known as a conjugation reaction . </Li> <Li> The final compounds have a larger molecular weight . </Li> </Ul> <Li> These reactions involve covalent attachment of small polar endogenous molecule such as glucuronic acid, sulfate, or glycine to form water - soluble compounds . </Li>

The role of liver as an organ of biotransformation