<P> It was released theatrically on March 16, 2012, by Columbia Pictures and Metro - Goldwyn - Mayer and grossed $201 million . A sequel, titled 22 Jump Street, was released on June 13, 2014 . Two further films, MIB 23 (a crossover with the Men in Black franchise) and a female - led spin - off, are currently in development . </P> <P> In 2005, scholarly student Morton Schmidt (Jonah Hill) and popular underachieving jock Greg Jenko (Channing Tatum) miss their school prom; Schmidt being rejected by the girl he asked to be his date and Jenko being barred from attending because of his grades . Seven years later, the duo meets again at the Police Academy and become friends and partners on bicycle patrol . They catch a break when they arrest Domingo (DeRay Davis), the leader of a one - percenter motorcycle gang, but are forced to release him after they failed to read him his Miranda rights . </P> <P> The duo is reassigned to a revived scheme from the 1980s, which specializes in infiltrating high schools . Captain Dickson (Ice Cube) assigns them to contain the spread of a synthetic drug called HFS at Sagan High School . He gives them new identities and enrolls them as students, giving them class schedules fitting their previous academic performances; Jenko taking mostly arts and humanities, and Schmidt taking mostly science classes, but the duo mixes up their identities . Schmidt gets a lead on HFS from classmate Molly (Brie Larson), and he and Jenko meet the school's main dealer, popular student Eric (Dave Franco). The two take HFS in front of him to maintain their cover . After experiencing the drug's effects, the duo discovers that Schmidt's intelligence now makes him popular, while Jenko's lax attitude is frowned upon . </P> <P> Eric takes a liking to Schmidt, who develops a romantic interest in Molly . Jenko becomes friends with the students in his AP Chemistry class and finds himself becoming more interested in geeky hobbies and academic pursuits . Schmidt and Jenko throw a party at Schmidt's parents' house, where they are living during the course of their assignment, and invite Eric . During the party, a fight breaks out between Schmidt, Jenko, and some party crashers . Schmidt wins the fight, solidifying his social status and gaining Eric's trust . Jenko's friends hack Eric's phone to enable them to listen in on his conversations . </P>

What was the drug on 21 jump street