<P> A major city of the Ohio Valley, Cincinnati is situated on the north bank of the Ohio River in Hamilton County, which is the extreme southwestern county of the state of Ohio . It is midway by river between the cities of Pittsburgh, Pennsylvania and Cairo, Illinois . The city lies opposite the mouth of the Licking River, an important factor in its being sited where it is . </P> <P> Cincinnati's core metro area spans parts of southern Ohio and northern Kentucky . According to the United States Census Bureau, the city has a total area of 79.54 square miles (206.01 km), of which 77.94 square miles (201.86 km) are land and 1.60 square miles (4.14 km) are water . The city spreads over a number of hills, bluffs, and low ridges overlooking the Ohio River in the Bluegrass region of the country . Cincinnati is geographically located within the Midwest and is on the far northern periphery of the Upland South . Two - thirds of the American population live within a one - day drive of the city . </P> <P> Three enclaves lie within Cincinnati's city limits: Norwood, Elmwood Place, and Saint Bernard . Norwood is a significant business and industrial city, while Elmwood Place and Saint Bernard are small, primarily residential, villages . Cincinnati does not have an exclave, but the city government does own several properties outside the corporation limits: French Park in Amberley Village, the disused runway at the former Blue Ash Airport in Blue Ash, and the 337 - mile - long (542 km) Cincinnati Southern Railway, which runs between Cincinnati and Chattanooga, Tennessee . </P> <P> Downtown Cincinnati is focused around Fountain Square, a public square and event location . </P>

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