<P> In 2013 researchers first reported DMT in the pineal gland microdialysate of rodents . </P> <P> A study published in 2014 reported the biosynthesis of N, N - dimethyltryptamine (DMT) in the human melanoma cell line SK - Mel - 147 including details on its metabolism by peroxidases . </P> <P> In a 2014 paper a group first demonstrated the immunomodulatory potential of DMT and 5 - MeO - DMT through the Sigma - 1 receptor of human immune cells . This immunomodulatory activity may contribute to significant anti-inflammatory effects and tissue regeneration . </P> <P> The first claimed detection of mammalian endogenous DMT was published in June 1965: German researchers F. Franzen and H. Gross report to have evidenced and quantified DMT, along with its structural analog bufotenin (5 - HO - DMT), in human blood and urine . In an article published four months later, the method used in their study was strongly criticized, and the credibility of their results challenged . </P>

What is the function of dmt in humans