<Tr> <Td> </Td> <Td> 56.2 </Td> <Td> Agonist </Td> </Tr> <Tr> <Td> </Td> <Td> 22.4 </Td> <Td> Unknown </Td> </Tr> <P> Following a single oral dose, resorption of cabergoline from the gastrointestinal (GI) tract is highly variable, typically occurring within 0.5 to 4 hours . Ingestion with food does not alter its absorption rate . Human bioavailability has not been determined since the drug is intended for oral use only . In mice and rats the absolute bioavailability has been determined to be 30 and 63 percent, respectively . Cabergoline is rapidly and extensively metabolized in the liver and excreted in bile and to a lesser extent in urine . All metabolites are less active than the parental drug or inactive altogether . The human elimination half - life is estimated to be 63 to 68 hours in patients with Parkinson's disease and 79 to 115 hours in patients with pituitary tumors . Average elimination half - life is 80 hours . </P> <P> The therapeutic effect in treatment of hyperprolactinemia will typically persist for at least 4 weeks after cessation of treatment . </P>

How long does cabergoline stay in your system
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