<Tr> <Th> Vasodilation and increased permeability </Th> <Td> <Ul> <Li> Histamine </Li> <Li> PAF </Li> <Li> Leukotriene C4, D4, and E4 </Li> <Li> Prostaglandin D2 </Li> <Li> Neutral proteases </Li> </Ul> </Td> </Tr> <Ul> <Li> Histamine </Li> <Li> PAF </Li> <Li> Leukotriene C4, D4, and E4 </Li> <Li> Prostaglandin D2 </Li> <Li> Neutral proteases </Li> </Ul> <Li> Leukotriene C4, D4, and E4 </Li> <Tr> <Th> Smooth muscle spasm </Th> <Td> <Ul> <Li> Histamine </Li> <Li> PAF </Li> <Li> Leukotriene C4, D4, and E4 </Li> <Li> Prostaglandin </Li> </Ul> </Td> </Tr>

Which of the following is the most severe form of type i immediate hypersensitivity