<P> Nurse Jackie was created by Liz Brixius, Linda Wallem, and Evan Dunsky . Brixius and Wallem served as showrunners for the first four seasons and shared executive producer duties with Caryn Mandabach and John Melfi . Showtime ordered an initial 12 episodes . Before the premiere, Brixius told the New York Daily News that "Guys' stories tend to be about conquests--getting the job, winning the Olympics, whatever . Women ('s) stories aren't as immediately climactic so they need to play out over the course of three months...And every medical show out there has been about doctors . Doctors are absolutely unable to do what they have to do without nurses . We want to tell those stories ." </P> <P> The June 8, 2009, series premiere was Showtime's most successful ever, with 1 million viewers for the premiere and over 350,000 for the repeat broadcast . Showtime immediately picked up the series for a second season . Season Three premiered on Showtime on March 28, 2011 . On May 23, 2011, Showtime ordered a fourth season . A fifth season was ordered on May 31, 2012, and production began in late 2012 . The season 4 finale aired on June 17, 2012 . Season 5 premiered on April 14, 2013, with new showrunner and executive producer Clyde Phillips . On June 6, 2013, Showtime renewed the show for a sixth season, which premiered on April 13, 2014 . </P> <P> On March 31, 2014, Showtime renewed Nurse Jackie for a seventh season, which was announced the following September as being the show's final season . It premiered April 12, 2015 . </P> <P> Main character Jackie Peyton was described by Showtime as a "strong - willed, iconoclastic New York City nurse juggling the frenzied grind of an urban hospital and an equally challenging personal life," noting that the character had "an occasional weakness for Vicodin, Percocet, and Xanax to get her through the days ." The main characters included Dr. Eleanor O'Hara (Eve Best), a British doctor and Jackie's best friend at work; Zoey Barkow (Merritt Wever), a spunky, but inexperienced, nursing student from a community college, who "is the perfect foil for Jackie's sharp angles"; Dr. Fitch Cooper (Peter Facinelli), "a likable' golden boy' whose calm façade hides a nervous disposition"; and Eddie Walzer (Paul Schulze), a pharmacist with whom Jackie was having an affair at the beginning of the series . </P>

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