<Tr> <Th> MeSH </Th> <Td> D015427 </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Reperfusion injury or reperfusion insult, sometimes called ischemia - reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re - + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia). The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than (or along with) restoration of normal function . </P> <P> Reperfusion of ischemic tissues is often associated with microvascular injury, particularly due to increased permeability of capillaries and arterioles that lead to an increase of diffusion and fluid filtration across the tissues . Activated endothelial cells produce more reactive oxygen species but less nitric oxide following reperfusion, and the imbalance results in a subsequent inflammatory response . The inflammatory response is partially responsible for the damage of reperfusion injury . White blood cells, carried to the area by the newly returning blood, release a host of inflammatory factors such as interleukins as well as free radicals in response to tissue damage . The restored blood flow reintroduces oxygen within cells that damages cellular proteins, DNA, and the plasma membrane . Damage to the cell's membrane may in turn cause the release of more free radicals . Such reactive species may also act indirectly in redox signaling to turn on apoptosis . White blood cells may also bind to the endothelium of small capillaries, obstructing them and leading to more ischemia . Another hypothesis would be that normally, tissues contain free radical scavengers to avoid damage by oxidizing species normally contained in the blood . Ischemic tissue would have decreased function of these scavengers because of cell injury . Once blood flow is reestablished, oxygen species contained in the blood will damage the ischemic tissue because the function of the scavengers is decreased . </P>

Once oxygen is returned to a damaged heart reperfusion injury occurs as a result of
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