<P> Outside of Nate's apartment, Nate tells Dan (Penn Badgley) about his parents' divorce and their conversation is interrupted by Rufus (Matthew Settle) calling Dan about Serena, who has been hospitalized because of a potentially fatal overdose . Back in Hudson, Jenny receives news from Rufus about Serena's overdose and consequently drives Jenny's guilt, not realizing that Juliet had gone too far in her plans of destroying Serena, and Jenny sets off for New York . Vanessa, unaware that Serena is hospitalized, finds herself alone when she arrives at the van der Woodsen apartment and receives a text from Jenny implying that their plan to ruin had gone too far . </P> <P> At the hospital, the family receives news that Serena had been taking medication meant for treating depression . Believing that her daughter has returned to her old habits, Lily has Serena involuntarily committed to the Ostroff Center . At the Ostroff Center, Serena furiously refuses to be committed at the center, saying that she didn't drug herself . While everyone thinks that Serena is in denial, Dan chooses to believe Serena's sentiment . At Juliet's apartment, Jenny tells Juliet that she'll be telling the truth to everyone, prompting Juliet to pack her bags and leave . As Vanessa makes her way to the Ostroff Center to talk to Dan, she calls Juliet and expresses that they should tell the truth about what they did to Serena . Juliet tells Vanessa that if Jenny tells the truth, they'll eventually forgive her because she's a family member but Vanessa won't be given the same kind of forgiveness, further driving Vanessa to self - preservation by including that her involvement will drive Dan back to Serena . At the Ostroff Center, Blair and Chuck are surprised to see Jenny, who in turn is surprised when she receives a scolding from Rufus . Vanessa tells Jenny that she told Rufus everything and lays the blame on her . A shocked Lily enters when she realizes that Serena is missing from her room . </P> <P> At the prison, Nate is surprised to see his mother, who has changed her mind about visiting his father . Helping Serena escape, Dan rushes her off to the Humphrey loft and plan a road trip . Their plans are cut short when Lily catches them and Serena isolates herself from her mother while Lily confronts Dan, who expresses his frustrations at Lily's choosing to ignore Serena . Rufus continues to scold Jenny for what she did and as Jenny explains the truth, Rufus continues his scolding, causing Jenny to leave . As Blair convinces Serena to get better, Gossip Girl sends a blast consisting of photos of Juliet in Serena's guise doing drugs and partying, causing Serena to doubt herself and return to the Ostroff Center . While visiting her brother in prison, Juliet reveals that she drugged Serena and even shocks Ben (David Call) for what she has done, saying that drugging her is going to far in their plans to ruin her . Juliet expresses her anger at losing her place and her life in Columbia in her attempt at trying to ruin Serena and leaves her brother . On her way out, she spots Nate and his parents and hurriedly leaves . Hoping to find Juliet, Jenny sees trash bags on the floor of her empty apartment, picks up the mask that Juliet used to drug Serena, and realizes that Juliet has escaped . </P> <P> Despite his efforts, Anne Archibald (Francie Swift) continues to move forward with her divorce from his father (Sam Robards) and disappoints Nate . When a furious Blair sees Jenny walk into her apartment, Jenny confesses what she, Vanessa and Juliet did . Realizing the truth, Blair offers Jenny an opportunity to help her find Juliet but Jenny turns it down, telling Blair that she was right in banishing her and leaves . At a hotel bar, Lily pays Juliet for her silence in what seems to be one of Serena's past transgressions, unaware that of Juliet's plans of escaping . At the prison, Nate hears that his mother's visit was just in time for his father's parole approval while at the Empire Hotel, Chuck receives Blair's father's pumpkin pie as a sign of goodwill from Blair . Vanessa, in contrast, receives a text from Jenny that she confessed everything to Blair . Fearing Blair's wrath, Vanessa calls her mother and leaves town . Meanwhile, Serena and her family happily spend Thanksgiving at the Ostroff Center . </P>

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