<P> Scream Queens is an American comedy horror television series that aired on Fox from September 22, 2015, to December 20, 2016 . The series was created by Ryan Murphy, Brad Falchuk, and Ian Brennan and produced by Murphy, Falchuk, Brennan, and Alexis Martin Woodall . Scream Queens is produced by 20th Century Fox Television, Ryan Murphy Productions, Brad Falchuck Teley - vision, and Prospect Films . The first season takes place at the fictional Wallace University, being produced in New Orleans, Louisiana . One of the sororities, Kappa Kappa Tau, becomes plagued by a serial killer, who uses the university's Red Devil mascot as a disguise in an attempt to kill people . </P> <P> On January 15, 2016, Fox renewed the series for a second season, which premiered on September 20, 2016 . Emma Roberts, Jamie Lee Curtis, Billie Lourd, Lea Michele, Abigail Breslin, Niecy Nash, Glen Powell, Keke Palmer, and Oliver Hudson reprise their roles while John Stamos, Taylor Lautner, James Earl, and Kirstie Alley were added to the cast, and the season wasn't set in a university, instead it was a hospital, produced in Los Angeles, California . </P> <P> The show was canceled on May 15, 2017, after two seasons . </P> <P> The first season focuses on the Kappa Kappa Tau sorority at Wallace University, led by Chanel Oberlin (Emma Roberts) and her fellow Chanels #2 (Ariana Grande), #3 (Billie Lourd), and #5 (Abigail Breslin), that is threatened by Dean Cathy Munsch (Jamie Lee Curtis). Events reignite a 20 - year - old murder mystery, with the reemergence of the serial killer dressed as the Red Devil mascot, who begins targeting the sorority members . </P>

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