<P> Necrotizing fasciitis affects about 0.4 in every 100,000 people per year in the United States . There were about 1,000 cases of necrotising fasciitis cases per year in the United States, however, the rates have been increasing . This could be due to increasing awareness of this condition, leading to increased reporting, or there could be increasing bacterial virulence, or increasing bacterial resistance against antibiotics . In some areas of the world it is as common as 1 in every 100,000 people . </P> <P> Higher rates of necrotising fasciities are seen in those with obesity, diabetes, immunocompromised, alcholic, or with peripheral vascular disease . However, such disease may also occurs in young healthy adults with no underlying illnesses . Non-steroidal anti-inflammatory drug (NSAIDs) may have increase the rates of necrotising infections due to the modification of immune response in the body . This is because NSAIDs inbihits the cycloxygenase - 1 and cycloxygenase - 2 enzymes which are important in producing thromboxane and prostaglandin E2 . Prostaglandin has been responsible for fever, inflammation, and pain . The inhibition of prostangladin E2 production reduces inflammatory response and leukocyte adhesion, thus reduces immune response against bacterial invasion, giving rise to soft tissue infection . </P> <P> In the 5th century BC, Hippocrates described necrotising soft tissue infection as a disease which was the complication of Streptococcal infection where those affected would have "erysipelas all over the body while the cause was only a trivial accident . Bones, flesh, and sinew (cord, tendon, or nerve) would fall off from the body and there were many deaths". The first English description for necrotising soft tissue infection was by British surgeon Leonard Gillespie and British physicians Gilbert Blaine and Thomas Trotter in the 18th century . At that time, necrotising soft tissue infection was known as phagedaenic (gnaw - biting or chewing which gradually make a hole or destroying it) ulcer, phagedena gangrenous, gangrenous ulcer, malignant ulcer, putrid ulcer, or hospital gangrene . Later the word "hospital gangrene" become more commonly used . In 1871, Confederate States Army surgeon Joseph Jones reported 2,642 cases of hospital gangrene with mortality rate of 46% . In 1883, Dr Jean - Alfred Fournier described the necrotising infection of the perineum and scrotum which termed as Fournier gangrene today . The term "Necrotising fasciitis" was first coined by Wilson in 1952 . The definition of necrotising fasciitis has become broader, to include not only infection of fascia, but also other soft tissue infection . </P> <Ul> <Li> 1994 Lucien Bouchard, former premier of Québec, Canada, who became infected while leader of the federal official opposition Bloc Québécois party, lost a leg to the illness . </Li> <Li> 1994 A cluster of cases occurred in Gloucestershire, in the west of England . Of five confirmed and one probable infection, two died . The cases were believed to be connected . The first two had acquired the Streptococcus pyogenes bacteria during surgery, the remaining four were community - acquired . The cases generated much newspaper coverage, with lurid headlines such as "Flesh Eating Bug Ate My Face". </Li> <Li> 1997 Ken Kendrick, former agent and partial owner of the San Diego Padres and Arizona Diamondbacks, contracted the disease . He had seven surgeries in a little more than a week and later fully recovered . </Li> <Li> 2004 Eric Allin Cornell, winner of the 2001 Nobel Prize in Physics, lost his left arm and shoulder to the disease . </Li> <Li> 2005 Alexandru Marin, an experimental particle physicist, professor at MIT, Boston University and Harvard University, and researcher at CERN and JINR, died from the disease . </Li> <Li> 2006 Alan Coren, British writer and satirist, announced in his Christmas column for The Times that his long absence as a columnist had been caused by his contracting the disease while on holiday in France . </Li> <Li> 2009 R.W. Johnson, British journalist and historian, contracted the disease in March after injuring his foot while swimming . His leg was amputated above the knee . </Li> <Li> 2011 Jeff Hanneman, guitarist for the thrash metal band Slayer, contracted the disease . He died of liver failure two years later, on May 2, 2013, and it was speculated his infection might be the cause of death . However, on May 9, 2013, the official cause of death was announced as alcohol - related cirrhosis . Hanneman and his family had apparently been unaware of the extent of the condition until shortly before his death . </Li> <Li> 2011 Peter Watts, Canadian science fiction author, contracted the disease . On his blog, Watts reported, "I'm told I was a few hours away from being dead...If there was ever a disease fit for a science fiction writer, flesh - eating disease has got to be it . This...spread across my leg as fast as a Star Trek space disease in time - lapse ." </Li> <Li> 2014 Daniel Gildenlöw, Swedish singer and songwriter for the band Pain of Salvation spent several months in hospital after being diagnosed with necrotizing fasciitis on his back in early 2014 . After recovering he went to write the album' In the Passing Light of Day', a concept album about his experience during the hospitalization . </Li> <Li> 2015 Edgar Savisaar, Estonian politician . His right leg was amputated . He got the disease during a trip to Thailand . </Li> </Ul>

Where did the flesh eating bacteria come from
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