<Tr> <Td_colspan="2"> ← Previous Season 10 Next → Season 12 </Td> </Tr> <Tr> <Td_colspan="2"> List of Grey's Anatomy episodes </Td> </Tr> <P> The eleventh season of the American television medical drama Grey's Anatomy premiered on September 25, 2014 in the United States on the American Broadcasting Company (ABC) and consists of 25 episodes . The season was produced by ABC Studios, in association with Shondaland Production Company and The Mark Gordon Company; the showrunners being Stacy McKee and William Harper . The season commenced airing with the episode "I Must Have Lost it on the Wind" and concluded with the season finale "You're My Home" airing on May 14, 2015 . The season was officially released on DVD as a six - disc boxset under the title of Grey's Anatomy: The Complete Eleventh Season--Life Changes on August 18, 2015 by Buena Vista Home Entertainment . </P> <P> The season is the first in which Dr. Cristina Yang, portrayed by Sandra Oh, is not included in the main cast of characters following her departure in previous season's finale . The season's main storylines include Meredith Grey (Ellen Pompeo) dealing with "her person's" departure, her problematic love - life with male - lead of the show Derek Shepherd (Patrick Dempsey), and new replacement for Yang, Dr. Maggie Pierce (Kelly McCreary) learning that Meredith is her half - sister . The biggest storyline of Season 11 was the death of Derek who is involved in a car accident in "How to Save a Life ." Other story - arcs include Amelia Shepherd (Caterina Scorsone) moving to Seattle, learning the ropes at Grey Sloan Memorial Hospital, Callie Torres (Sara Ramirez) and Arizona Robbins (Jessica Capshaw) try to save their marriage by going to marriage counseling, April Kepner (Sarah Drew) and Jackson Avery (Jesse Williams) end up having a boy, named Samuel, who dies moments after birth having been diagnosed to have Osteogenesis imperfecta, a lethal birth defect . The season also focuses on the deepening friendship between Meredith and Alex Karev (Justin Chambers) causing problems for him and girlfriend Jo Wilson (Camilla Luddington). </P>

When did season 11 of grey's anatomy air