<P> Partially hydrogenated vegetable oils have been an increasingly significant part of the human diet for about 100 years (in particular, since the later half of the 20th century and where more processed foods are consumed), and some deleterious effects of trans fat consumption are scientifically accepted, forming the basis of the health guidelines discussed above . </P> <P> The exact biochemical process by which trans fats produce specific health problems are a topic of continuing research . One theory is that the human lipase enzyme works only on the cis configuration and cannot metabolize a trans fat although this theory has been overturned by the recognition that trans fat is metabolized but competitively inhibits the metabolism of other fatty acids . Intake of dietary trans fat perturbs the body's ability to metabolize essential fatty acids (EFAs including Omega 3) leading to changes in the phospholipid fatty acid composition in the aorta, the main artery of the heart, thereby increasing risk of coronary artery disease . </P> <P> While the mechanisms through which trans fats contribute to coronary artery disease are fairly well understood, the mechanism for trans fat's effect on diabetes is still under investigation . Trans fatty acids may impair the metabolism of long - chain polyunsaturated fatty acids (LCPUFAs), but maternal pregnancy trans fatty acid intake has been inversely associated with LCPUFAs levels in infants at birth thought to underlie the positive association between breastfeeding and intelligence . </P> <P> High intake of trans fatty acids can lead to many health problems throughout one's life . Trans fat is abundant in fast food restaurants . It is consumed in greater quantities by people who do not have access to a diet consisting of fewer hydrogenated fats, or who often consume fast food . A diet high in trans fats can contribute to obesity, high blood pressure, and a greater risk for heart disease . Trans fat has also been implicated in the development of Type 2 diabetes . </P>

Where do trans fats go in the body