<Li> Fibrotic phase - collagenous fibrosis with lack of marrow elements </Li> <P> These disorders are still being revised according to more specific genetic mutations and how often patients end in a fibrotic marrow event . </P> <P> Polycythemia vera (PV) is associated most often with the JAK2 V617F mutation in greater than 95% of cases, whereas the remainder have a JAK2 exon 12 mutation: </P> <Ul> <Li> Cellular phase - increased megakaryocytes which cluster, reticulin fibrosis, later trichrome fibrosis, and increased myeloid and erythroid precursors </Li> <Li> Fibrotic phase - collagenous fibrosis with lack of marrow elements </Li> </Ul>

Icd 10 code for jak2 positive myeloproliferative neoplasm