<Li> George P. Mahoney, a building contractor who undoubtedly with his candidacies led to the creation of a future Vice President . Mahoney, a conservative Democrat from Maryland who ran for U.S. Senate in 1952, 1956, 1958, 1968, and 1970 and for Governor of Maryland as a Democrat in 1950, 1954, 1962, and 1966 . Mahoney won the Democratic nomination for Governor in 1966 with just 30.21% of the vote . U.S. Representative Carlton R. Sickles (29.84%) and Attorney General of Maryland Thomas B. Finan (27.31%) split the vote and allowed Mahoney, who ran on a segregationist and anti-open housing campaign to triumph . In the general election, Mahoney's slogan, "Your home is your castle; protect it", as well as his stance on many civil rights issues, prompted Baltimore City Comptroller Hyman A. Pressman to enter the race as an Independent candidate . Mahoney's controversial stances caused many liberals in the Maryland Democratic Party to split their support between Spiro Agnew, due to his pro-civil rights, socially moderate views, and Pressman . This split helped Agnew to win the election with a plurality, taking 70% of the black vote . Agnew in 1969 became Vice President of the United States under Richard Nixon . </Li> <Li> Basil Marceaux, during the 2010 election cycle filed as a candidate for the Republican nominations for governor in the Tennessee gubernatorial election and U.S. House of Representatives in Tennessee's 3rd congressional district . Before his 2010 candidacies for Governor and the U.S. House, Marceaux had previously run as a candidate for the Tennessee State Senate three times, the United States Senate once and the Governor of Tennessee in three separate elections . </Li> <Li> Andy Martin (also known as Anthony Martin - Trigona), a journalist and self - described consumer advocate has run for several local, state and federal offices dating back to at least 1977, including two runs for president and six runs for Senate . He has run as a Democrat, a Republican and as an independent . </Li> <Li> James D. Martin, one of the first Republican politicians to make an electoral impact in the once solid - Democratic state of Alabama, ran for the U.S. Senate three times and governor of Alabama once in the 1960s and 1970s, and also unsuccessfully sought the office of state treasurer in 1994 . By the time of Martin's 1978 Senate campaign, his opponent had already acknowledged him as the "Harold Stassen of Alabama ." </Li>

Who has run for president the most times and lost