<Tr> <Th> Children </Th> <Td> </Td> </Tr> <Tr> <Th> Awards </Th> <Td> Emmy Awards Tony Award </Td> </Tr> <P> Laura Elizabeth "Laurie" Metcalf (born June 16, 1955) is an American actress . She is known for her television roles as Jackie Harris on the ABC sitcom Roseanne (1988--97); Carolyn Bigsby on Desperate Housewives (2006); the recurring role of Mary Cooper on The Big Bang Theory (2007--present); Dr. Jenna James on Getting On (2013--15), and Marjorie McCarthy in The McCarthys (2014--15). She voiced the role of Mrs. Davis in the Toy Story film series . Her other film appearances include Making Mr. Right (1987), JFK (1991), Mistress (1992), and as Debbie Salt / Mrs. Loomis in Scream 2 (1997). She has also appeared in commercials for Plan USA, a humanitarian organization which helps children in need around the world . </P> <P> Metcalf began her career with the Steppenwolf Theater Company and frequently works in Chicago theater, including the 1983 revival of Balm in Gilead . A ten - time Emmy Award nominee, she won three consecutive Emmys for Roseanne from 1992 to 1994 . In 2012, she starred as Mary Tyrone in a London production of Eugene O'Neill's Long Day's Journey into Night at the Apollo Theatre . She has received a Theatre World Award and two Obie Awards for her Off - Broadway work . A four - time Tony Award nominee for her work on Broadway, Metcalf won the Tony Award for Best Actress in a Play in 2017 for her role in A Doll's House, Part 2 . </P>

Who plays sheldons sister on big bang theory