<P> Instead of accumulating inside the muscle cells, lactate produced by anaerobic fermentation is taken up by the liver . This initiates the other half of the Cori cycle . In the liver, gluconeogenesis occurs . From an intuitive perspective, gluconeogenesis reverses both glycolysis and fermentation by converting lactate first into pyruvate, and finally back to glucose . The glucose is then supplied to the muscles through the bloodstream; it is ready to be fed into further glycolysis reactions . If muscle activity has stopped, the glucose is used to replenish the supplies of glycogen through glycogenesis . </P> <P> Overall, the glycolysis part of the cycle produces 2 ATP molecules at a cost of 6 ATP molecules consumed in the gluconeogenesis part . Each iteration of the cycle must be maintained by a net consumption of 4 ATP molecules . As a result, the cycle cannot be sustained indefinitely . The intensive consumption of ATP molecules indicates that the Cori cycle shifts the metabolic burden from the muscles to the liver . </P> <P> The cycle's importance is based on the prevention of lactic acidosis in the muscle under anaerobic conditions . However, normally before this happens the lactic acid is moved out of the muscles and into the liver . </P> <P> The cycle is also important in producing ATP, an energy source, during muscle activity . The Cori cycle functions more efficiently when muscle activity has ceased . This allows the oxygen debt to be repaid such that the Krebs cycle and electron transport chain can produce energy at peak efficiency . </P>

What is the importance of the cori cycle
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