<P> The 1933 K.B.S. Productions Sherlock Holmes film A Study in Scarlet follows a strikingly similar plot; it includes a scene where Holmes is shown a card with the hint: "Six little Indians...bee stung one and then there were five". In this case, the rhyme refers to "Ten Little Fat Boys". (The film's plot bears no resemblance to Arthur Conan Doyle's original story of the same name .) The author of the movie's screenplay, Robert Florey, "doubted that (Christie) had seen A Study in Scarlet, but he regarded it as a compliment if it had helped inspire her". </P> <P> And Then There Were None has had more adaptations than any other single work by Agatha Christie . It is the isolated location where all the players on scene are murdered, never knowing who their murderer is, that is the idea . "It was an idea which is now the basis for many Hollywood horror films and has become a cliché to modern audiences, but it was Agatha Christie who was the first to do it and so successfully that the story has become her most adapted piece ." She changed the bleak ending to a more palatable one for theatre audiences when she adapted the novel for the stage in 1943 . Many adaptations incorporate changes to the story, such as using Christie's alternative ending from her stage play or changing the setting to locations other than an island . </P> <P> With a plot line so well known, parodies and references to the novel or the play are frequent . Many television programs use the essence of the plot, a group of characters cut off from the outside world with a murderer in their midst, but with innocent victims in place of guilty victims, and give no credit to Agatha Christie for the many differences in plot and motivation . </P> <P> There have been numerous film adaptations of the novel, some comedic . Examples include: </P>

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