<Table> <Tr> <Td_colspan="2"> View / Edit Human </Td> <Td_colspan="2"> View / Edit Mouse </Td> </Tr> </Table> <Tr> <Td_colspan="2"> View / Edit Human </Td> <Td_colspan="2"> View / Edit Mouse </Td> </Tr> <P> Human hemochromatosis protein also known as the HFE protein is a protein which in humans is encoded by the HFE gene . The HFE gene is located on short arm of chromosome 6 at location 6p21. 3 Unusually, the official gene symbol (HFE for High Iron Fe) is not an abbreviation of the official name (hemochromatosis). </P> <P> Protein encoded by this gene is a membrane protein that is similar to MHC class I - type proteins and associates with beta - 2 microglobulin (beta2M). It is thought that this protein functions to regulate circulating iron uptake by regulating the interaction of the transferrin receptor with transferrin . </P>

What protein does the hfe gene code for