<P> The fourteenth season of the American television medical drama Grey's Anatomy was ordered on February 10, 2017, by American Broadcasting Company (ABC), and premiered on September 28, 2017 with a special two - hour premiere . The season will consist of 24 episodes, with the season's seventh episode marking the 300th episode for the series overall . The season is produced by ABC Studios, in association with Shondaland Production Company and The Mark Gordon Company; the showrunners being Krista Vernoff and William Harper . </P> <P> The fourteenth season is the first not to feature Jerrika Hinton as Dr. Stephanie Edwards since her introduction in the ninth season, following her departure at the conclusion of the previous season . The season marks the last appearance of Martin Henderson, Jason George, Jessica Capshaw, and Sarah Drew as series regulars, as well as the first appearance of Jaina Lee Ortiz as Andy Herrera, the lead character of Grey's Anatomy's second spin - off series, Station 19 . </P> <P> On April 20, 2018, ABC officially renewed Grey's Anatomy for a network primetime drama record - setting fifteenth season . </P> <P> The season follows the story of surgical residents, fellows, and attendings as they experience the difficulties of the competitive careers they have chosen . It is set in the surgical wing of the fictional Grey Sloan Memorial Hospital, located in Seattle, Washington . </P>

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