<Li> General transcription factor binding sites, e.g. TATA box </Li> <Li> Proximal promoter--the proximal sequence upstream of the gene that tends to contain primary regulatory elements <Ul> <Li> Approximately 250 base pairs upstream of the start site </Li> <Li> Specific transcription factor binding sites </Li> </Ul> </Li> <Ul> <Li> Approximately 250 base pairs upstream of the start site </Li> <Li> Specific transcription factor binding sites </Li> </Ul> <Li> Approximately 250 base pairs upstream of the start site </Li>

How will transcription be affected if the promoter region malfunctions