<P> Haemochromatosis may present with the following clinical syndromes: </P> <Ul> <Li> Cirrhosis of the liver: Varies from zonal iron deposition to fibrosis (cirrhosis). </Li> <Li> Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death . </Li> <Li> Cardiomyopathy </Li> <Li> Arthritis, from calcium pyrophosphate deposition in joints . The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers . </Li> <Li> Testicular failure </Li> <Li> Bronzing of the skin . This deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: "bronze diabetes". </Li> <Li> Joint pain and bone pain </Li> </Ul> <Li> Cirrhosis of the liver: Varies from zonal iron deposition to fibrosis (cirrhosis). </Li> <Li> Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death . </Li>

Which of the following is a direct result of overload