<Tr> <Th> Spouse (s) </Th> <Td> Edgar Bethune Ward (m . 1935; his death 2000) </Td> </Tr> <Tr> <Th> Children </Th> <Td> </Td> </Tr> <P> Jane Waddington Wyatt (August 12, 1910--October 20, 2006) was an American actress . She starred in a number of Hollywood films, but is likely best known for her role as the housewife and mother Margaret Anderson on the CBS and NBC television comedy series, Father Knows Best, and as Amanda Grayson, the human mother of Spock on the science - fiction television series Star Trek . Wyatt was a three - time Emmy Award - winner . </P> <P> Jane Waddington Wyatt was born on August 12, 1910, in Mahwah, New Jersey, but raised in Manhattan . Her father, Christopher Billopp Wyatt, Jr., was a Wall Street investment banker, and her mother, the former Euphemia Van Rensselaer Waddington, was a drama critic for the Catholic World . Both of her parents were Roman Catholic converts . </P>

Who played the mother on father knows best