<P> In 2007, two teams--the Los Angeles Dodgers and the Baltimore Orioles--played six games with more than one interleague opponent . The Dodgers played both the Toronto Blue Jays and the Los Angeles Angels of Anaheim while the Orioles played both the Arizona Diamondbacks and the Washington Nationals . This happened again in 2012 as the New York Yankees played both the New York Mets and the Atlanta Braves for six games . The Miami Marlins also did this, playing both the Tampa Bay Rays and Boston Red Sox for six games each . </P> <P> The first Civil Rights Game was an exhibition interleague game between the Cleveland Indians and St. Louis Cardinals at AutoZone Park in Memphis on March 31, 2007 . The first regular season Civil Rights Game was an interleague game between the Chicago White Sox and Cincinnati Reds at Great American Ball Park on June 20, 2009 . </P> <P> Since the introduction of interleague play, two teams have shifted leagues: the Milwaukee Brewers from the American League to the National League in 1998, and the Houston Astros from the National League to the American League in 2013 . As a result, a 2013 interleague series between the two teams made it the first time that two teams faced each other in an interleague series after both teams previously faced each other in an interleague series representing opposite leagues: the two teams met from September 1--3, 1997 (Houston in NL, Milwaukee in AL), then again from June 18--20, 2013 (Houston in AL, Milwaukee in NL). In both instances, the series took place in Houston, with the team representing the American League winning 2 - 1 . From 1998 to 2012, both teams were division opponents in the National League Central . </P> <P> Interleague play has largely favored the American League in terms of win - loss records . In 22 years of play, the AL has won the season series 17 times, including 14 straight from 2004 - 2017 . With the Pirates sweeping the Royals on September 19, 2018, the National League is guaranteed the series win for the first time since 2003 . </P>

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