<P> March 2009 recommendations from the USPSTF on the use of aspirin for the primary prevention of coronary heart disease encourage men aged 45--79 and women aged 55--79 to use aspirin when the potential benefit of a reduction in MI for men or stroke for women outweighs the potential harm of an increase in gastrointestinal hemorrhage . The WHI study said regular low dose (75 or 81 mg) aspirin female users had a 25% lower risk of death from cardiovascular disease and a 14% lower risk of death from any cause . Low - dose aspirin use was also associated with a trend toward lower risk of cardiovascular events, and lower aspirin doses (75 or 81 mg / day) may optimize efficacy and safety for people requiring aspirin for long - term prevention . </P> <P> In children with Kawasaki disease, aspirin is taken at dosages based on body weight, initially four times a day for up to two weeks and then at a lower dose once daily for a further six to eight weeks . </P> <P> Aspirin should not be taken by people who are allergic to ibuprofen or naproxen, or who have salicylate intolerance or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID - precipitated bronchospasm . Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using aspirin . Even if none of these conditions is present, the risk of stomach bleeding is still increased when aspirin is taken with alcohol or warfarin . People with hemophilia or other bleeding tendencies should not take aspirin or other salicylates . Aspirin is known to cause hemolytic anemia in people who have the genetic disease glucose - 6 - phosphate dehydrogenase deficiency, particularly in large doses and depending on the severity of the disease . Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency . People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, thus may exacerbate these conditions . Aspirin should not be given to children or adolescents to control cold or influenza symptoms, as this has been linked with Reye's syndrome . </P> <P> Aspirin use has been shown to increase the risk of gastrointestinal bleeding . Although some enteric - coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk . Combining aspirin with other NSAIDs has also been shown to further increase this risk . Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding . </P>

When might the administration of aspirin be contraindicated
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