<Li> Absorption--How is the API absorbed (through the skin, the intestine, the oral mucosa)? </Li> <Li> Distribution--How does the API spread through the organism? </Li> <Li> Metabolism--Is the API converted chemically inside the body, and into which substances . Are these active (as well)? Could they be toxic? </Li> <Li> Excretion--How is the API excreted (through the bile, urine, breath, skin)? </Li>

The principal forms of drug administration include which of the following