<P> In the brain, the parenchyma refers to the functional tissue in the brain that is made up of the two types of brain cell, neurons and glial cells . Damage or trauma to the brain parenchyma often results in a loss of cognitive ability or even death . </P> <P> Lung parenchyma is the substance of the lung outside of the circulation system that is involved with gas exchange and includes the alveoli and respiratory bronchioles . </P> <P> In cancer, the parenchyma refers to "The portion of a tissue that lies outside the circulatory system and is often responsible for carrying out the specialized functions of the tissue". </P> <P> In plants, "parenchyma" is one of the three main types of ground tissue, and the most common . It can be distinguished through their thin cell wall as compared to other cells . Parenchyma cells make up the bulk of the soft parts of plants, including the insides of leaves, flowers and fruits (but not the epidermis or veins of these structures). </P>

Damage to the parenchyma cells can lead to which of the following issues