<Li> have bone pain, headache, back pain, or a nerve - related symptom (such as "shooting" pains in the leg) that is directly associated with the disease; </Li> <Li> have elevated levels of serum alkaline phosphatase (ALP) in their blood; </Li> <Li> display evidence that a bone fracture will occur; </Li> <Li> require pretreatment therapy for affected bones that require surgery; </Li>

Increased serum calcium level may indicate osteomalacia osteoporosis and bone tumors