<P> Capacitation is the penultimate step in the maturation of mammalian spermatozoa and is required to render them competent to fertilize an oocyte . This step is a biochemical event; the sperm move normally and look mature prior to capacitation . In vivo, capacitation typically occurs after ejaculation into the female reproductive tract . In vitro, capacitation can occur by incubating sperm that have either undergone ejaculation or have been extracted from the epididymis in a defined medium for several hours . </P> <P> The uterus aids in the steps of capacitation by secreting sterol - binding albumin, lipoproteins, and proteolytic and glycosidasic enzymes such as heparin . </P>

Where does capacitation of sperm normally take place
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