<P> Synapsis (also called syndesis) is the pairing of two homologous chromosomes that occurs during meiosis . It allows matching - up of homologous pairs prior to their segregation, and possible chromosomal crossover between them . Synapsis takes place during prophase I of meiosis . When homologous chromosomes synapse, their ends are first attached to the nuclear envelope . These end - membrane complexes then migrate, assisted by the extranuclear cytoskeleton, until matching ends have been paired . Then the intervening regions of the chromosome are brought together, and may be connected by a protein - RNA complex called the synaptonemal complex . Autosomes undergo synapsis during meiosis, and are held together by a protein complex along the whole length of the chromosomes called the synaptonemal complex . Sex chromosomes also undergo synapsis; however, the synaptonemal protein complex that holds the homologous chromosomes together is only present at one end of each sex chromosome . </P> <P> This is not to be confused with mitosis . Mitosis also has prophase, but does not ordinarily do pairing of two homologous chromosomes . </P> <P> When the non-sister chromatids intertwine, segments of chromatids with similar sequence may break apart and be exchanged in a process known as genetic recombination or "crossing - over". This exchange produces a chiasma, a region that is shaped like an X, where the two chromosomes are physically joined . At least one chiasma per chromosome often appears to be necessary to stabilise bivalents along the metaphase plate during separation . The crossover of genetic material also provides a possible defence against' chromosome killer' mechanisms, by removing the distinction between' self' and' non-self' through which such a mechanism could operate . A further consequence of recombinant synapsis is to increase genetic variability within the offspring . Repeated recombination also has the general effect of allowing genes to move independently of each other through the generations, allowing for the independent concentration of beneficial genes and the purging of the detrimental . </P>

Does pairing of homologous chromosomes take place in mitosis
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