<Tr> <Th> Relatives </Th> <Td> Adam West (brother - in - law) Thelma Griffin (mother - in - law) Francis Griffin (father - in - law) Karen Griffin (sister - in - law) </Td> </Tr> <Tr> <Th> Nationality </Th> <Td> American </Td> </Tr> <P> Lois Patrice Griffin (née Pewterschmidt) is one of the main characters of the American animated television series Family Guy . She is voiced by writer Alex Borstein and first appeared on television, along with the rest of the Griffin family, in the 15 - minute short on December 20, 1998 . Lois was created and designed by series creator Seth MacFarlane . MacFarlane was asked to pitch a pilot to the Fox Broadcasting Company based on Larry and Steve, a short he made which featured a middle - aged character named Larry and an intellectual dog, Steve . After the pilot was given the green light, the Griffin family appeared on the episode "Death Has a Shadow". </P> <P> Lois is the mother of the Griffin family . She and husband, Peter, have three children: Meg, Chris, and Stewie, along with the family dog, Brian . Lois is often portrayed as a stereotypical television mother, despite her admitting to being a recovering methamphetamine addict and a kleptomaniac . Lois has also had several affairs, one of which allegedly resulted in the conception of Meg . She has appeared in other media relating to Family Guy--including a video game, commercials and books--and inspired an entire line of merchandise . Lois's distinctive New York accent originated from a character in a stage show that Alex Borstein performed in, which was largely inspired by a relative who grew up on Long Island, New York . </P>

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