<Table> <Tr> <Td> </Td> <Td> This article needs additional citations for verification . Please help improve this article by adding citations to reliable sources . Unsourced material may be challenged and removed . (May 2013) (Learn how and when to remove this template message) </Td> </Tr> </Table> <Tr> <Td> </Td> <Td> This article needs additional citations for verification . Please help improve this article by adding citations to reliable sources . Unsourced material may be challenged and removed . (May 2013) (Learn how and when to remove this template message) </Td> </Tr> <P> Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796 . He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox . The word "vaccine" is derived from Variolae vaccinae (i.e. smallpox of the cow), the term devised by Jenner to denote cowpox and used in the long title of his An enquiry into the causes and effects of Variolae vaccinae, known by the name of cow pox . Vaccination, the term which soon replaced cowpox inoculation and vaccine inoculation, was first used in print by Jenner's friend, Richard Dunning in 1800 . Initially, the terms vaccine / vaccination referred only to smallpox, but in 1881 Louis Pasteur proposed that to honour Jenner the terms be widened to cover the new protective inoculations being introduced . </P> <P> The mortality of the severe form of smallpox--variola major--was very high without vaccination, up to 35% in some outbreaks . A method of inducing immunity known as inoculation, insufflation or "variolation" was practiced before the development of a modern vaccine and likely occurred in Africa and China well before the practice arrived in Europe . It may also have occurred in India, but this is disputed; other investigators contend the ancient Sanskrit medical texts of India do not describe these techniques . The first clear reference to smallpox inoculation was made by the Chinese author Wan Quan (1499--1582) in his Douzhen xinfa (痘 疹 心 法) published in 1549 . Inoculation for smallpox does not appear to have been widespread in China until the reign era of the Longqing Emperor (r . 1567--1572) during the Ming Dynasty . In China, powdered smallpox scabs were blown up the noses of the healthy . The patients would then develop a mild case of the disease and from then on were immune to it . The technique did have a 0.5--2.0% mortality rate, but that was considerably less than the 20--30% mortality rate of the disease itself . Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of the East India Company stationed in China and another by Clopton Havers . According to Voltaire (1742), the Turks derived their use of inoculation to neighbouring Circassia . Voltaire does not speculate on where the Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". </P>

Who came up with the vaccine for smallpox