<Tr> <Td_colspan="2"> CREST syndrome (calcinosis and sclerodactyly) </Td> </Tr> <Tr> <Th> Specialty </Th> <Td> Rheumatology </Td> </Tr> <P> CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder . The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia . It is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension . </P> <P> CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). </P>

Raynaud phenomenon is a symptom or complication of what disorders