<Tr> <Td> NADH </Td> <Td> NAD </Td> </Tr> <Tr> <Td> </Td> <Td_colspan="2"> </Td> <Td> </Td> </Tr> <P> Pyruvate is sold as a weight - loss supplement, though evidence supporting this use is lacking . A systematic review of six trials found a statistically significant difference in body weight with pyruvate compared to placebo . However, all of the trials had methodological weaknesses and the magnitude of the effect was small . The review also identified adverse events associated with pyruvate such as diarrhea, bloating, gas, and increase in low - density lipoprotein (LDL) cholesterol . The authors concluded that there was insufficient evidence to support the use of pyruvate for weight loss . </P> <P> There is also in vitro as well as in vivo evidence in hearts that pyruvate improves metabolism by NADH production stimulation and increases cardiac function . </P>

Where is lactic acid converted to pyruvic acid