<Tr> <Th> Specialty </Th> <Td> Neurology </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a long term pain syndrome that often worsens with time . It is characterized by severe pain out of proportion to the original injury and is often accompanied by sensitivity, swelling, and changes in the skin . It may initially affect one limb and then spread throughout the body; 35% of affected people report symptoms throughout their whole body . </P> <P> The cause of CRPS is unknown though CRPS is associated with dysregulation of the central nervous system and autonomic nervous system resulting in abnormal temperature control and pain of the affected limb (s) resulting in functional impairment and disability . Precipitating factors include injury and surgery, although there are cases where no identifiable injury had occurred at the original site . CRPS is not caused by psychological factors, yet the constant pain and reduced quality of life are known to cause psychological problems (such as increased depression and anxiety). Although "research does not reveal support for specific personality or psychopathology predictors of the condition," CRPS is associated with psychosocial effects, including impaired social and occupational function . It is classified as an amplified musculoskeletal pain syndrome . </P>

Complex regional pain syndrome/reflex sympathetic dystrophy (crps)