<Ol> <Li> positive selection, in which those double - positive T cells that bind to foreign antigen in the presence of self MHC . They will differentiate into either CD4+ or CD8+ depending on which MHC is associated with the antigen presented (MHC1 for CD8, MHC2 for CD4). In this case, the cells would have been presented antigen in the context of MHC1 . Positive selection means selecting those TCRs capable of recognizing self MHC molecules . </Li> <Li> negative selection, in which those double - positive T cells that bind too strongly to MHC - presented self antigens undergo apoptosis because they could otherwise become autoreactive, leading to autoimmunity . </Li> </Ol> <Li> positive selection, in which those double - positive T cells that bind to foreign antigen in the presence of self MHC . They will differentiate into either CD4+ or CD8+ depending on which MHC is associated with the antigen presented (MHC1 for CD8, MHC2 for CD4). In this case, the cells would have been presented antigen in the context of MHC1 . Positive selection means selecting those TCRs capable of recognizing self MHC molecules . </Li> <Li> negative selection, in which those double - positive T cells that bind too strongly to MHC - presented self antigens undergo apoptosis because they could otherwise become autoreactive, leading to autoimmunity . </Li> <P> Only those T cells that bind to the MHC - self - antigen complexes weakly are positively selected . Those cells that survive positive and negative selection differentiate into single - positive T cells (either CD4+ or CD8+), depending on whether their TCR recognizes an MHC class I - presented antigen (CD8) or an MHC class II - presented antigen (CD4). It is the CD8+ T - cells that will mature and go on to become cytotoxic T cells following their activation with a class I - restricted antigen . </P>

Which of the following cells can be a target for cytotoxic t-cells