<P> Izzie's cancer storyline received a mixed response from the medical community . Otis Brawley, chief medical officer at the American Cancer Society, commented that Izzie's treatment options were unrealistic . Whereas in the show she was offered the drug interleukin - 2, in reality the drug is never recommended to patients when melanoma has spread to the brain, as it can cause bleeding and strokes . Brawley explained that such patients would instead be offered radiosurgery . Conversely however, Tim Turnham, executive director of the Melanoma Research Foundation, praised Grey's Anatomy for bringing about greater public awareness of melanoma, stating: "We welcome the national spotlight Grey's Anatomy has created for melanoma and its efforts to encourage viewers to learn more about the importance of prevention, early detection and research ." </P> <P> The number in the "No. in series" column refers to the episode's number within the overall series, whereas the number in the "No. in season" column refers to the episode's number within this particular season . "U.S. viewers in millions" refers to the number of Americans in millions who watched the episodes live . The fifth season's episodes are altogether 1080 minutes in length . </P> <Table> <Tr> <Th> No . overall </Th> <Th> No. in season </Th> <Th> Title </Th> <Th> Directed by </Th> <Th> Written by </Th> <Th> Original air date </Th> <Th> U.S. viewers (millions) </Th> </Tr> <Tr> <Th> 79 80 </Th> <Td> </Td> <Td> "Dream a Little Dream of Me" </Td> <Td> Rob Corn Michael Pressman </Td> <Td> Shonda Rhimes </Td> <Td> September 25, 2008 (2008 - 09 - 25) </Td> <Td> 18.30 </Td> </Tr> <Tr> <Td_colspan="7"> A military doctor piques Cristina's interest and she helps him . In turn, he helps her when she gets stabbed by an icicle . Meredith and Derek attempt to work on their "happily ever after" and the attendings are stressed over Seattle Grace's ranking of number twelve . Alex is offended when Izzie talks to Meredith about how great a man Alex is . While a deadly ice storm ravages Seattle, Derek is stabbed with the scalpel in the palm of his hand by Rose and the Chief is stunned over Mercy West's increase in the number of patients . </Td> </Tr> <Tr> <Th> 81 </Th> <Td> </Td> <Td> "Here Comes the Flood" </Td> <Td> Michael Pressman </Td> <Td> Krista Vernoff </Td> <Td> October 9, 2008 (2008 - 10 - 09) </Td> <Td> 14.54 </Td> </Tr> <Tr> <Td_colspan="7"> Meredith quits therapy explaining to Dr. Wyatt that she doesn't need it anymore and that her life is fine how it is . Dr. Webber holds a meeting with all of the doctors and explains the new teaching system . After the meeting he shakes up all of the doctors' specialties, taking them off their own cases and putting them on to different ones . George attempts to retake his intern exam only for his exam room to go underwater . Derek attempts to make Izzie and Alex move out, forcing Izzie to ask Cristina to buy an apartment with her, only for Callie and Cristina to assume she was giving it to them . While Erica tries to explain to Callie why she doesn't want Mark to know everything about their relationship, Mark fights his temptations with Lexie . </Td> </Tr> <Tr> <Th> 82 </Th> <Td> </Td> <Td> "Brave New World" </Td> <Td> Eric Stoltz </Td> <Td> Debora Cahn </Td> <Td> October 16, 2008 (2008 - 10 - 16) </Td> <Td> 14.57 </Td> </Tr> <Tr> <Td_colspan="7"> A disgruntled Chief Webber implements new rules that has everyone on edge and tense . Meredith freaks out when Derek discovers her mother's old diary in the house while Callie frets as she prepares for her first official date with Erica . George finds out he passed his intern exam and is now a resident, and Cristina stumbles into a part of the hospital where everything is run differently . </Td> </Tr> <Tr> <Th> 83 </Th> <Td> 5 </Td> <Td> "There's No' I' in Team" </Td> <Td> Randy Zisk </Td> <Td> Jenna Bans </Td> <Td> October 23, 2008 (2008 - 10 - 23) </Td> <Td> 14.21 </Td> </Tr> <Tr> <Td_colspan="7"> Bailey orchestrates a massive 12 - person simultaneous "domino" surgery with six separate kidney transplants . Alex and Izzie share a kiss, Callie sleeps with Mark, and a rift comes between Meredith and Derek when their clinical trial is published and called the Shepherd method with no inclusion of Meredith . </Td> </Tr> <Tr> <Th> 84 </Th> <Td> 6 </Td> <Td> "Life During Wartime" </Td> <Td> James Frawley </Td> <Td> Mark Wilding </Td> <Td> October 30, 2008 (2008 - 10 - 30) </Td> <Td> 15.05 </Td> </Tr> <Tr> <Td_colspan="7"> Dr. Owen Hunt returns to Seattle Grace, being named as the new Head of Trauma Surgery - all part of the Chief's effort to raise the #12 ranking, and it works, raising Seattle Grace back to a Level I Trauma Center . Hunt uses his unorthodox treatment and teaching methods, rubbing Izzie, Derek, Mark and Cristina the wrong way . In keeping with his spirit of raising the #12 rank, the Chief has Bailey and Hahn perform tumor resection deemed impossible by many other hospitals . Callie tries to find out who she really is . </Td> </Tr> <Tr> <Th> 85 </Th> <Td> 7 </Td> <Td> "Rise Up" </Td> <Td> Joanna Kerns </Td> <Td> William Harper </Td> <Td> November 6, 2008 (2008 - 11 - 06) </Td> <Td> 15.63 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie faces her past of Denny Duquette when a certain patient comes into the hospital . Hahn finds out about the Denny / Izzie relationship for the first time, and blames Izzie for the patient's current condition . While talking over the situation with Callie, Callie takes Izzie's side, leading Hahn to say she can't be "kind of" a lesbian, and she walks off . Meanwhile, Derek blackmails Mark into helping him by sleeping with Cristina so that she will stop calling Meredith in the middle of the night and Izzie begins to see hallucinations of Denny, and she can't figure out why . </Td> </Tr> <Tr> <Th> 86 </Th> <Td> 8 </Td> <Td> "These Ties That Bind" </Td> <Td> Eric Stoltz </Td> <Td> Stacy McKee </Td> <Td> November 13, 2008 (2008 - 11 - 13) </Td> <Td> 15.59 </Td> </Tr> <Tr> <Td_colspan="7"> Sadie Harris (Melissa George), Meredith's best friend from college, arrives as a surgical intern at Seattle Grace Hospital, making Cristina jealous of their special friendship . A man wants his transplanted heart removed for spiritual reasons . The interns continue to practice on each other . It is revealed that Hahn quit her job as the Chief of cardiothoracic surgery at Seattle Grace Hospital and moved away, leaving Callie devastated and Chief Webber baffled . </Td> </Tr> <Tr> <Th> 87 </Th> <Td> 9 </Td> <Td> "In the Midnight Hour" </Td> <Td> Tom Verica </Td> <Td> Tony Phelan & Joan Rater </Td> <Td> November 20, 2008 (2008 - 11 - 20) </Td> <Td> 15.74 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie reveals her passionate love to Denny and Mark discovers that he has feelings for Lexie . The interns open up Sadie to remove her appendix, but when things get complicated, they have to approach Cristina and Meredith for help . When the chief finds out about the appendix operation, tensions flare between Cristina and Meredith . </Td> </Tr> <Tr> <Th> 88 </Th> <Td> 10 </Td> <Td> "All By Myself" </Td> <Td> Arlene Sanford </Td> <Td> Peter Nowalk </Td> <Td> December 4, 2008 (2008 - 12 - 04) </Td> <Td> 15.15 </Td> </Tr> <Tr> <Td_colspan="7"> Cristina is awarded the first solo surgery among the residents, but she has to relinquish it and choose her replacement; Mark performs a cutting - edge procedure to restore a patient's speech, impressing Lexie in the process . Callie cannot figure out if Sadie is flirting with her or just being friendly and Mark desperately tries to get Lexie out of his head . </Td> </Tr> <Tr> <Th> 89 </Th> <Td> 11 </Td> <Td> "Wish You Were Here" </Td> <Td> Rob Corn </Td> <Td> Debora Cahn </Td> <Td> January 8, 2009 (2009 - 01 - 08) </Td> <Td> 13.71 </Td> </Tr> <Tr> <Td_colspan="7"> Meredith and Cristina are still at odds with each other while George has a young patient who put her life on hold because she keeps having accidents . While Dr. Webber mourns the sudden death of the pediatric surgeon, Dr. Bailey is unhappy with the new one, and Derek and Meredith disagree about the treatment of a death - row prisoner . Izzie tries to tell Alex about Denny and Mark finally stops fighting his attraction to Lexie . First appearance of Dr. Arizona Robbins . </Td> </Tr> <Tr> <Th> 90 </Th> <Td> 12 </Td> <Td> "Sympathy for the Devil" </Td> <Td> Jeannot Szwarc </Td> <Td> Jenna Bans </Td> <Td> January 15, 2009 (2009 - 01 - 15) </Td> <Td> 12.95 </Td> </Tr> <Tr> <Td_colspan="7"> Derek still doesn't approve of Meredith showing sympathy for the death - row prisoner and Dr. Bailey continues aiding Dr. Robbins to save a boy who needs a new liver . Callie treats a short man who underwent a risky procedure for two extra inches and Meredith freaks out about Derek's mom (Tyne Daly) visiting Seattle Grace . Hunt asks Cristina out and Izzie breaks up with Denny . </Td> </Tr> <Tr> <Th> 91 </Th> <Td> 13 </Td> <Td> "Stairway to Heaven" </Td> <Td> Allison Liddi - Brown </Td> <Td> Mark Wilding </Td> <Td> January 22, 2009 (2009 - 01 - 22) </Td> <Td> 14.25 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie is trying to figure out what Denny means by "I'm here for you". In the meantime, matters around the death - row patient get really rough while Bailey's patient continues to get worse, causing Bailey and Webber to cross the line . Lexie "breaks" Mark and Izzie comes to realize that she is sick . </Td> </Tr> <Tr> <Th> 92 </Th> <Td> 14 </Td> <Td> "Beat Your Heart Out" </Td> <Td> Julie Anne Robinson </Td> <Td> William Harper </Td> <Td> February 5, 2009 (2009 - 02 - 05) </Td> <Td> 15.20 </Td> </Tr> <Tr> <Td_colspan="7"> Bailey is promoted to attending by the chief, but when she finds herself having another child - patient, she seriously doubts herself . Dr. Webber treats a couple who tried to spice up their sex - life and Derek prepares to propose . Dr. Dixon has a nervous breakdown when her patient's parents try to hug her, causing Bailey and Yang to give her a special treatment, and Sadie makes a bad mistake . Hunt and Cristina find themselves engaged in old - fashioned courting, and Dixon and Robbins both suggest that Dr. Bailey will make a good pediatric surgeon . Shepherd decides to postpone the proposal when he receives a call from Addison, and Arizona Robbins hits on Callie . </Td> </Tr> <Tr> <Th> 93 </Th> <Td> 15 </Td> <Td> "Before and After" </Td> <Td> Dan Attias </Td> <Td> Tony Phelan & Joan Rater </Td> <Td> February 12, 2009 (2009 - 02 - 12) </Td> <Td> 15.70 </Td> </Tr> <Tr> <Td_colspan="7"> <P> Addison (Kate Walsh) arrives with her brother Archer (Grant Show), who has worms in his brain . Cristina learns of Owen's pre-Iraq past and Bailey considers a pediatric surgery fellowship . Izzie enlists the help of the attendings and her fellow residents in a game to boost camaraderie amongst the interns, and George finds out that Sadie is behind with her skills, forcing her to make a decision . Derek and Mark spend the evening reminiscing on their med school days with Addison, Naomi Bennett, and Sam Bennett . </P> This episode begins a crossover with Private Practice that concludes on "Ex-Life". </Td> </Tr> <Tr> <Th> 94 </Th> <Td> 16 </Td> <Td> "An Honest Mistake" </Td> <Td> Randy Zisk </Td> <Td> Peter Nowalk </Td> <Td> February 19, 2009 (2009 - 02 - 19) </Td> <Td> 15.39 </Td> </Tr> <Tr> <Td_colspan="7"> Addison stays to help delivering the baby of one of Derek's patients and Cristina gets into trouble with a senior doctor . Callie is being called a baby and Bailey has trouble getting a decent letter of recommendation from the chief . Izzie gets the news about her false test - result and investigates the matter further . Mark tells Derek about his seeing Lexie . </Td> </Tr> <Tr> <Th> 95 </Th> <Td> 17 </Td> <Td> "I Will Follow You Into the Dark" </Td> <Td> James Frawley </Td> <Td> Jenna Bans </Td> <Td> March 12, 2009 (2009 - 03 - 12) </Td> <Td> 13.54 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie walks the interns through diagnosing Patient X after receiving her troubling test results . Bailey and Meredith perform a surgery where they remove a woman's stomach to protect her from a very invasive form of stomach cancer that runs in her family . Hunt and Karev treat a high school marching band player with seizures . Shepherd faces a lawsuit after his patient from the previous episode dies . Cristina receives some disturbing news from one of her colleagues . </Td> </Tr> <Tr> <Th> 96 </Th> <Td> 18 </Td> <Td> "Stand By Me" </Td> <Td> Jessica Yu </Td> <Td> Zoanne Clack </Td> <Td> March 19, 2009 (2009 - 03 - 19) </Td> <Td> 14.36 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie doesn't want to fight the brain tumor, despite Cristina's efforts to help her . This starts affecting Cristina's surgery performance so she tells everyone and Izzie is admitted at the hospital as a patient . Big surgery going on, facial transplant . George and Meredith try to mediate a fight between two interns caused by a love triangle . Meanwhile, Chief Webber stresses over Derek's absence and how to dissuade him from quitting . </Td> </Tr> <Tr> <Th> 97 </Th> <Td> 19 </Td> <Td> "Elevator Love Letter" </Td> <Td> Edward Ornelas </Td> <Td> Stacy McKee </Td> <Td> March 26, 2009 (2009 - 03 - 26) </Td> <Td> 15.81 </Td> </Tr> <Tr> <Td_colspan="7"> Derek prepares for Izzie's surgery to remove her brain tumor, with the attention of the hospital rising . Owen has another PTSD episode that leads him to strangle Cristina, which traumatizes her . Derek proposes to Meredith in the elevator, while Cristina breaks up with Owen . </Td> </Tr> <Tr> <Th> 98 </Th> <Td> 20 </Td> <Td> "Sweet Surrender" </Td> <Td> Tony Phelan </Td> <Td> Sonay Washington </Td> <Td> April 23, 2009 (2009 - 04 - 23) </Td> <Td> 13.22 </Td> </Tr> <Tr> <Td_colspan="7"> Bailey learns of the heart - wrenching practices in pediatrics . Callie's father (Héctor Elizondo) visits her at work, and after learning of her relationship with Arizona, he tries to take her home (by transferring her to another hospital, in exchange for a donation to the hospital), but ends up having no success . Izzie undergoes chemotherapy as she begins to plan Derek and Meredith's wedding . Owen tells George that his specialty is definitely trauma surgery . </Td> </Tr> <Tr> <Th> 99 </Th> <Td> 21 </Td> <Td> "No Good at Saying Sorry (One More Chance)" </Td> <Td> Tom Verica </Td> <Td> Krista Vernoff </Td> <Td> April 30, 2009 (2009 - 04 - 30) </Td> <Td> 13.94 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie's mother comes to visit her . Callie is dealing with loss of her trust fund, which her father took away when he found out her new lesbian status . Meredith and Lexie's father shows up . He's recovering and getting sobered up, but Meredith's not able to forgive him and gets caught up in drama with the chief over how to handle a case involving a man shot by his young daughter . Mark gains the courage to meet Lexie's father . </Td> </Tr> <Tr> <Th> 100 </Th> <Td> 22 </Td> <Td> "What a Difference a Day Makes" </Td> <Td> Rob Corn </Td> <Td> Shonda Rhimes </Td> <Td> May 7, 2009 (2009 - 05 - 07) </Td> <Td> 15.33 </Td> </Tr> <Tr> <Td_colspan="7"> As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER . Meanwhile, Izzie fears the worst when it is discovered that she has another brain tumor . Callie and Arizona have a fight over their previous date, while George learns the consequences of being a trauma surgeon . Meredith performs her first solo surgery, and later gives her and Derek's wedding to Izzie and Alex as a result of Izzie having another brain tumor . </Td> </Tr> <Tr> <Th> 101 </Th> <Td> 23 </Td> <Td> "Here's to Future Days" </Td> <Td> Bill D'Elia </Td> <Td> Allan Heinberg </Td> <Td> May 14, 2009 (2009 - 05 - 14) </Td> <Td> 15.58 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level . A patient makes Owen reassess his place at Seattle Grace, leading him to visit his mother for the first time since he came back from the war . George, after working on the case with Owen, decides to join the army, and Izzie undergoes surgery after signing a DNR chart . </Td> </Tr> <Tr> <Th> 102 </Th> <Td> 24 </Td> <Td> "Now or Never" </Td> <Td> Rob Corn </Td> <Td> Debora Cahn </Td> <Td> May 14, 2009 (2009 - 05 - 14) </Td> <Td> 17.12 </Td> </Tr> <Tr> <Td_colspan="7"> Izzie finally wakes up from surgery, only for everyone to realize that her short - term memory has gone bad; this worries Alex to a point where he yells at her, only to have her remember everything he said . Arizona offers Bailey the peds fellowship, but Bailey's not too happy about it . News spreads about George joining the army . The doctors (besides Izzie) focus on a "John Doe" who jumped in front of a bus to save a woman's life . Derek and Meredith plan to go to city hall to get married, only to be so busy that they write their vows on a post-it note . Mark tries to ask Lexie to move in with him only to be shot down . Dr. Bailey and Callie organize an intervention to talk George out of joining the army . However, when "John Doe" writes "O-O - 7" on Meredith's hand, she realizes that it's George . Izzie loses consciousness again . </Td> </Tr> </Table> <Tr> <Th> No . overall </Th> <Th> No. in season </Th> <Th> Title </Th> <Th> Directed by </Th> <Th> Written by </Th> <Th> Original air date </Th> <Th> U.S. viewers (millions) </Th> </Tr>

When do izzie and alex get together in season 5
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