<Tr> <Th> MeSH </Th> <Td> D008661 </Td> </Tr> <Tr> <Td_colspan="2"> (edit on Wikidata) </Td> </Tr> <P> Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of metabolism . The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into others (products). In most of the disorders, problems arise due to accumulation of substances which are toxic or interfere with normal function, or to the effects of reduced ability to synthesize essential compounds . Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic disorders . The term inborn errors of metabolism was coined by a British physician, Archibald Garrod (1857--1936), in 1908 . He is known for work that prefigured the "one gene - one enzyme" hypothesis, based on his studies on the nature and inheritance of alkaptonuria . His seminal text, Inborn Errors of Metabolism was published in 1923 . </P> <P> Traditionally the inherited metabolic diseases were classified as disorders of carbohydrate metabolism, amino acid metabolism, organic acid metabolism, or lysosomal storage diseases . In recent decades, hundreds of new inherited disorders of metabolism have been discovered and the categories have proliferated . Following are some of the major classes of congenital metabolic diseases, with prominent examples of each class . Many others do not fall into these categories . </P>

Who wrote the book inborn errors of metabolism