<Tr> <Td> There is no well - tested treatment for this difficult problem and no data to confidently inform clinical practice . </Td> </Tr> <Tr> <Td> <Table> <Tr> <Th> (show) Outcome </Th> <Th> Findings in words </Th> <Th> Findings in numbers </Th> <Th> Quality of evidence </Th> </Tr> <Tr> <Th_colspan="4"> Hypersalivation </Th> </Tr> <Tr> <Td> No effect / not cured / not markedly improved Control: propantheline </Td> <Td> Astemizole probably is probably worse than propantheline - increasing the risk of having' no effect' . Data are based on moderate quality evidence . </Td> <Td> RR 2.46 (1.63 to 3.72) </Td> <Td> Moderate </Td> </Tr> <Tr> <Td> Change in hypersalivation scores (high = good) Control: propantheline </Td> <Td> On average, people receiving astemizole scored a little lower than people treated with control for clozapine - induced hypersalivation . There was a clear difference between the groups, but, at present the meaning of this in day - to - day care is unclear . </Td> <Td> MD 0.64 lower (1.14 lower to 0.14 lower) </Td> <Td> Low </Td> </Tr> <Tr> <Th_colspan="4"> Adverse effects </Th> </Tr> <Tr> <Td> Tachycardia Control: doxepin </Td> <Td> Astemizole may increase the risk of experiencing fast heart rate, but, at present it is not possible to be confident about the difference between the two treatments because data supporting this finding are very limited . </Td> <Td> RR 5.00 (0.25 to 99.16) </Td> <Td> Very low </Td> </Tr> <Tr> <Td> Constipation Control: propantheline </Td> <Td> Astemizole may reduce constipation but there is no clear difference between people given astemizole and those receiving propanthelinecontrol for clozapine - induced hypersalivation . These findings are based on data of low quality . </Td> <Td> RR 0.60 (0.26 to 1.39) </Td> <Td> Low </Td> </Tr> <Tr> <Th_colspan="4"> Missing outcomes </Th> </Tr> <Tr> <Td> </Td> <Td> No study reported any data on outcomes such as mental state, quality of life and information relating to time in services </Td> <Td> </Td> <Td> </Td> </Tr> </Table> </Td> </Tr> <Table> <Tr> <Th> (show) Outcome </Th> <Th> Findings in words </Th> <Th> Findings in numbers </Th> <Th> Quality of evidence </Th> </Tr> <Tr> <Th_colspan="4"> Hypersalivation </Th> </Tr> <Tr> <Td> No effect / not cured / not markedly improved Control: propantheline </Td> <Td> Astemizole probably is probably worse than propantheline - increasing the risk of having' no effect' . Data are based on moderate quality evidence . </Td> <Td> RR 2.46 (1.63 to 3.72) </Td> <Td> Moderate </Td> </Tr> <Tr> <Td> Change in hypersalivation scores (high = good) Control: propantheline </Td> <Td> On average, people receiving astemizole scored a little lower than people treated with control for clozapine - induced hypersalivation . There was a clear difference between the groups, but, at present the meaning of this in day - to - day care is unclear . </Td> <Td> MD 0.64 lower (1.14 lower to 0.14 lower) </Td> <Td> Low </Td> </Tr> <Tr> <Th_colspan="4"> Adverse effects </Th> </Tr> <Tr> <Td> Tachycardia Control: doxepin </Td> <Td> Astemizole may increase the risk of experiencing fast heart rate, but, at present it is not possible to be confident about the difference between the two treatments because data supporting this finding are very limited . </Td> <Td> RR 5.00 (0.25 to 99.16) </Td> <Td> Very low </Td> </Tr> <Tr> <Td> Constipation Control: propantheline </Td> <Td> Astemizole may reduce constipation but there is no clear difference between people given astemizole and those receiving propanthelinecontrol for clozapine - induced hypersalivation . These findings are based on data of low quality . </Td> <Td> RR 0.60 (0.26 to 1.39) </Td> <Td> Low </Td> </Tr> <Tr> <Th_colspan="4"> Missing outcomes </Th> </Tr> <Tr> <Td> </Td> <Td> No study reported any data on outcomes such as mental state, quality of life and information relating to time in services </Td> <Td> </Td> <Td> </Td> </Tr> </Table> <Tr> <Th> (show) Outcome </Th> <Th> Findings in words </Th> <Th> Findings in numbers </Th> <Th> Quality of evidence </Th> </Tr>

Why does my mouth produce so much spit