<P> The Cahill cycle, also known as the alanine cycle or glucose - alanine cycle, is the series of reactions in which amino groups and carbons from muscle are transported to the liver . It is quite similar to the Cori cycle in the cycling of nutrients between skeletal muscle and the liver . When muscles degrade amino acids for energy needs, the resulting nitrogen is transaminated to pyruvate to form alanine . This is performed by the enzyme alanine transaminase, which converts L - glutamate and pyruvate into α - ketoglutarate and L - alanine . The resulting L - alanine is shuttled to the liver where the nitrogen enters the urea cycle and the pyruvate is used to make glucose . </P> <P> The Cahill cycle is less productive than the Cori cycle, which uses lactate, since a byproduct of energy production from alanine is production of urea . Removal of the urea is energy - dependent, requiring four "high - energy" phosphate bonds (3 ATP hydrolyzed to 2 ADP and one AMP), thus the net ATP produced is less than that found in the Cori cycle . However, unlike in the Cori cycle, NADH is conserved because lactate is not formed . This allows for it to be oxidized via the electron transport chain . This pathway requires the presence of alanine aminotransferase, which is restricted to tissues such as muscle, liver, and the intestine . Therefore, this pathway is used instead of the Cori cycle only when an aminotransferase is present, when there is a need to transfer ammonia to the liver and when the body is in a state of catabolism (muscle breakdown). </P> <P> The alanine cycle also serves other purposes: </P>

Difference between cori cycle and glucose alanine cycle
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