<P> Smoking is known to increase levels of liver enzymes that break down drugs and toxins . That means that drugs cleared by these enzymes are cleared more quickly in smokers, which may result in the drugs not working . Specifically, levels of CYP1A2 and CYP2A6 are induced: substrates for 1A2 include caffeine and tricyclic antidepressants such as amitriptyline; substrates for 2A6 include the anticonvulsant, valproic acid . </P> <P> Studies suggest that smoking decreases appetite, but did not conclude that overweight people should smoke or that their health would improve by smoking . This is also a cause of heart diseases . Smoking also decreases weight by overexpressing the gene AZGP1 which stimulates lipolysis . </P> <P> Smoking causes about 10% of the global burden of fire deaths, and smokers are placed at an increased risk of injury - related deaths in general, partly due to also experiencing an increased risk of dying in a motor vehicle crash . </P> <P> Smoking increases the risk of symptoms associated with Crohn's disease (a dose - dependent effect with use of greater than 15 cigarettes per day). There is some evidence for decreased rates of endometriosis in infertile smoking women, although other studies have found that smoking increases the risk in infertile women . There is little or no evidence of a protective effect in fertile women . Some preliminary data from 1996 suggested a reduced incidence of uterine fibroids, but overall the evidence is unconvincing . </P>

Information on awareness about tobacco consumption and cancer