<P> Chronic administration is associated with hyperglycemia . </P> <P> Thiazides cause loss of blood potassium, while conserving blood calcium . </P> <P> Thiazides can decrease placental perfusion and adversely affect the fetus so should be avoided in pregnancy . </P> <P> There are several mechanisms by which thiazide diuretics cause hypokalemia (decreased plasma potassium concentration): </P>

Where do thiazide diuretics work in the nephron