<Tr> <Td> Zone of proliferation </Td> <Td> Chondrocytes undergo rapid mitosis under influence of growth hormone </Td> </Tr> <Tr> <Td> Zone of maturation and hypertrophy </Td> <Td> Chondrocytes stop mitosis, and begin to hypertrophy by accumulating glycogen, lipids, and alkaline phosphatase </Td> </Tr> <Tr> <Td> Zone of calcification </Td> <Td> Chondrocytes undergo apoptosis . Cartilagenous matrix begins to calcify . </Td> </Tr> <Tr> <Td> Zone of ossification </Td> <Td> Osteoclasts and osteoblasts from the diaphyseal side break down the calcified cartilage and replace with mineralized bone tissue . </Td> </Tr>

Epiphyses increase in size because of growth at the epiphyseal line