<Tr> <Th> Significant other (s) </Th> <Td> Lexie Grey (deceased) Addison Montgomery Callie Torres Teddy Altman Reed Adamson (deceased) Amelia Shepherd Julia Canner Nancy Shepherd </Td> </Tr> <P> Mark Everett Sloan, M.D., F.A.C.S. is a fictional surgeon from the ABC medical drama television series Grey's Anatomy, portrayed by Eric Dane . Dr. Sloan is an attending specializing in plastic surgery . Dr. Sloan earned the nickname "McSteamy" for his good looks by the female interns of Seattle Grace later Seattle Grace Mercy West Hospital . He was good friends with Dr. Derek Shepherd, a fellow physician at Seattle Grace, but was the catalyst for the end of Shepherd's marriage when Shepherd caught Sloan sleeping with his wife, Addison . Later, he pursues a' forbidden' relationship with Dr. Lexie Grey, straining his relationship with Derek yet again . He reveals that he loves Lexie in episodes "Migration", "Flight", "Going, Going, Gone", and "Remember The Time" In the show's ninth season, he dies of injuries sustained in a jet plane crash that also injured or killed several of his colleagues from the hospital . </P> <P> Mark first appears in season two, introduced as a highly respected otolaryngologist sub-specialized in plastic surgery and the childhood best friend of neurosurgeon Derek Shepherd (Patrick Dempsey). In his first appearance, he flirts with Meredith Grey, and Derek punches him in the face . Derek explains that Mark had an affair with his wife, Addison (Kate Walsh) while they were living in New York . Mark travels to Seattle, intent on convincing Addison to return with him, but his offer is rejected and Derek declines to renew their friendship . Mark returns during season three at Addison's drunken behest, but she again rejects him once sober . Undeterred, Mark sells his successful private practice (which he previously shared with Derek) and takes over the plastics program at Seattle Grace Hospital . During Meredith's morphine rampage, Mark finds out about his nickname McSteamy which was given to him by her during his first trip to Seattle back when he attempted to get Addison back and earn Derek's friendship back . It is later revealed that Mark has at some point slept with all of Derek's sisters . Mark has a brief fling with Addison's friend, orthopedic surgeon Callie Torres (Sara Ramirez), and develops a friendship with Derek's girlfriend, intern Meredith Grey (Ellen Pompeo). It is revealed that after Derek left New York, Mark and Addison continued their relationship for two months, during which she conceived and aborted his child . Just weeks after moving to Seattle he quickly observes that Derek's true love was Meredith and tries to convince Addison that her marriage with Derek was over . Mark enters into a sixty - day abstinence pact with Addison, agreeing that if they can remain celibate for that time, Addison will give their relationship another chance . Addison ultimately breaks the pact by having sex with intern Alex Karev (Justin Chambers), and soon thereafter departs from Seattle to work in Los Angeles . </P> <P> Mark supports Derek when Meredith comes close to dying after drowning, and the two are able to rekindle their friendship . It is eventually revealed that he and Derek grew up together and that he, having lost his mother as a child and emotionally neglected by his father, considered Derek's mother as his maternal figure . As he was an only child and Derek was the only son, they became close friends and he was Derek's best man at the latter's wedding to Addison . He also forms a friendship with Callie, and develops an attraction to cardiothoracic surgeon Erica Hahn (Brooke Smith). Erica does not reciprocate his feelings, and he is supportive of Callie when she and Erica have a brief relationship . When Addison shows up at Seattle Grace for a case, Mark attempts to sleep with Addison again but she refuses . The nurses later start a club against him called Nurses United Against Mark Sloan . After a string of unresolved sexual tension on his part, Mark then finds himself seduced by Lexie Grey (Chyler Leigh), despite Derek's request that he keep their relationship platonic even before their relationship had begun . They begin a sexual relationship, which Lexie halts until he is willing to publicly admit to being her partner . Mark eventually agrees and tells Derek, who attacks him . Animosity exists between them for several episodes, before they once more repair their friendship . Mark and Lexie's relationship becomes increasingly serious . He meets her father, Thatcher (Jeff Perry); and at the end of season five, asks her to move in with him . Though Lexie initially declines, he remains committed to their relationship, and she agrees early in season six . </P>

When does mark come in grey's anatomy