<P> Next day sedation can be worsened if people take zolpidem while they are also taking antipsychotics, other sedatives, anxiolytics, antidepressant agents, antiepileptic drugs, and antihistamines . Some people taking antidepressants have had visual hallucinations when they also took zolpidem . </P> <P> Cytochrome P450 inhibitors, particularly CYP3A4 and CYP1A2 inhibitors, fluvoxamine and ciprofloxacin will increase the effects of a given dose of zolpidem . </P> <P> Cytochrome P450 activators like St. John's Wort may decrease the activity of zolpidem . </P> <P> Three syntheses of zolpidem are common . 4 - methylacetophenone is used as a common precursor . This is brominated and reacted with 2 - amino - 5 - methylpyridine to give the imidazopyridine . From here the reactions use a variety of reagents to complete the synthesis, either involving thionyl chloride or sodium cyanide . These reagents are challenging to handle and require thorough safety assessments . Though such safety procedures are common in industry, they make clandestine manufacture difficult . </P>

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