<P> Cystic fibrosis is caused by mutations in the CFTR gene on chromosome 7, the most common mutation being ΔF508 (a deletion of a codon coding for phenylalanine, which occupies the 508th amino acid position in the normal CFTR polypeptide). Any of these mutations can prevent the proper folding of the protein and subsequent degradation, resulting in decreased numbers of chloride channels in the body . This causes the buildup of mucus in the body and chronic infections . </P> <Ul> <Li> GABA </Li> <Li> Glycine Receptor </Li> <Li> Calcium - activated chloride channel </Li> <Li> Anion - conducting channelrhodopsin </Li> </Ul> <Li> Calcium - activated chloride channel </Li> <Li> Anion - conducting channelrhodopsin </Li>

Molecular structure and physiological function of chloride channels