<Dd> Δ G / N = 10 R T σ 2 (\ displaystyle (\ Delta G / N = 10RT \ sigma ^ (2))) </Dd> <P> The difference in Gibbs free energy between the supercoiled circular DNA and uncoiled circular DNA with N> 2000 bp is approximated by: </P> <Dl> <Dd> Δ G / N = 700 K c a l / b p ∗ (Δ L k / N) (\ displaystyle (\ Delta G / N = 700Kcal / bp * (\ Delta Lk / N))) </Dd> </Dl> <Dd> Δ G / N = 700 K c a l / b p ∗ (Δ L k / N) (\ displaystyle (\ Delta G / N = 700Kcal / bp * (\ Delta Lk / N))) </Dd>

Briefly describe the cellular need for a type of enzyme that can relax supercoils