<Li> G6P can continue on the glycolysis pathway and be used as fuel . </Li> <Li> G6P can enter the pentose phosphate pathway via the enzyme glucose - 6 - phosphate dehydrogenase to produce NADPH and 5 - carbon sugars . </Li> <Li> In the liver and kidney, G6P can be dephosphorylated back to glucose by the enzyme glucose 6 - phosphatase . This is the final step in the gluconeogenesis pathway . </Li> <P> The most common disease in which glycogen metabolism becomes abnormal is diabetes, in which, because of abnormal amounts of insulin, liver glycogen can be abnormally accumulated or depleted . Restoration of normal glucose metabolism usually normalizes glycogen metabolism, as well . </P>

Where does glycogen synthesis take place in the cell