<P> In 1822, the first animal protection law was enacted in the British parliament, followed by the Cruelty to Animals Act (1876), the first law specifically aimed at regulating animal testing . The legislation was promoted by Charles Darwin, who wrote to Ray Lankester in March 1871: </P> <P> You ask about my opinion on vivisection . I quite agree that it is justifiable for real investigations on physiology; but not for mere damnable and detestable curiosity . It is a subject which makes me sick with horror, so I will not say another word about it, else I shall not sleep to - night ." </P> <P> Opposition to the use of animals in medical research arose in the United States during the 1860s, when Henry Bergh founded the American Society for the Prevention of Cruelty to Animals (ASPCA), with America's first specifically anti-vivisection organization being the American AntiVivisection Society (AAVS), founded in 1883 . </P> <P> In the UK, an article in the Medical Times and Gazette on April 28, 1877, indicates that anti-vivisectionist campaigners, mainly clergymen, had prepared a number of posters entitled, "This is vivisection," "This is a living dog," and "This is a living rabbit," depicting animals in a poses that they said copied the work of Elias von Cyon in St. Petersburg, though the article says the images differ from the originals . It states that no more than 10 or a dozen men were actively involved in animal testing on living animals in the UK at that time . </P>

How long has animal testing been a problem
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