<Tr> <Td_colspan="2"> In Wikidata </Td> </Tr> <P> Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones . Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor, that is present in almost every vertebrate animal cell . The name "glucocorticoid" is a portmanteau (glucose + cortex + steroid) and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). A less common synonym is glucocorticosteroid . </P> <P> Glucocorticoids are part of the feedback mechanism in the immune system which reduces certain aspects of immune function, such as inflammation . They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, and sepsis . Glucocorticoids have many diverse (pleiotropic) effects, including potentially harmful side effects, and as a result are rarely sold over the counter . They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer . This includes inhibitory effects on lymphocyte proliferation, as in the treatment of lymphomas and leukemias, and the mitigation of side effects of anticancer drugs . </P> <P> Glucocorticoids affect cells by binding to the glucocorticoid receptor . The activated glucocorticoid receptor - glucocorticoid complex up - regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression). </P>

What is the effect of glucocorticoids on the immune system
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