<P> Meta - analyses conclude that fluoroquinolones pose little or no additional risk to children compared to other antibiotic classes . </P> <P> Fluoroquinolines use in children may be appropriate when the infection is caused by multidrug - resistant bacteria, or when alternative treatment options require parenteral administration and oral therapy is preferred . </P> <P> While typical drug side effects reactions are mild to moderate; sometimes serious adverse effects occur . </P> <P> In 2016, the U.S. FDA stated that serious side effects generally outweighed the benefits for people with acute sinusitis, acute bronchitis, and uncomplicated urinary tract infections when there are other treatment options . In 2008 the FDA added black box warning on all fluoroquinolones, advising of the increased risk of tendon damage . In 2016 the FDA found that when used systemically (by mouth or injectable) "disabling and potentially permanent serious side effects" can involve the tendons, muscles, joints, nerves, and central nervous system . Concerns regarding low blood sugar and mental health problems were added in 2018 . </P>

Which of the following is an adverse reaction of floroquinolones