<P> The history of scientific method considers changes in the methodology of scientific inquiry, as distinct from the history of science itself . The development of rules for scientific reasoning has not been straightforward; scientific method has been the subject of intense and recurring debate throughout the history of science, and eminent natural philosophers and scientists have argued for the primacy of one or another approach to establishing scientific knowledge . Despite the disagreements about approaches, scientific method has advanced in definite steps . Rationalist explanations of nature, including atomism, appeared both in ancient Greece in the thought of Leucippus and Democritus, and in ancient India, in the Nyaya, Vaisesika and Buddhist schools, while Charvaka materialism rejected inference as a source of knowledge in favour of an empiricism that was always subject to doubt . Aristotle pioneered scientific method in ancient Greece alongside his empirical biology and his work on logic, rejecting a purely deductive framework in favour of generalisations made from observations of nature . </P> <P> Some of the most important debates in the history of scientific method center on: rationalism, especially as advocated by René Descartes; inductivism, which rose to particular prominence with Isaac Newton and his followers; and hypothetico - deductivism, which came to the fore in the early 19th century . In the late 19th and early 20th centuries, a debate over realism vs. antirealism was central to discussions of scientific method as powerful scientific theories extended beyond the realm of the observable, while in the mid-20th century some prominent philosophers argued against any universal rules of science at all . </P> <P> There are few explicit discussions of scientific methodologies in surviving records from early cultures . The most that can be inferred about the approaches to undertaking science in this period stems from descriptions of early investigations into nature, in the surviving records . An Egyptian medical textbook, the Edwin Smith papyrus, (c. 1600 BCE), applies the following components: examination, diagnosis, treatment and prognosis, to the treatment of disease, which display strong parallels to the basic empirical method of science and according to G.E.R. Lloyd played a significant role in the development of this methodology . The Ebers papyrus (c. 1550 BCE) also contains evidence of traditional empiricism . </P> <P> By the middle of the 1st millennium BCE in Mesopotamia, Babylonian astronomy had evolved into the earliest example of a scientific astronomy, as it was "the first and highly successful attempt at giving a refined mathematical description of astronomical phenomena ." According to the historian Asger Aaboe, "all subsequent varieties of scientific astronomy, in the Hellenistic world, in India, in Islam, and in the West--if not indeed all subsequent endeavour in the exact sciences--depend upon Babylonian astronomy in decisive and fundamental ways ." </P>

Who was the first to use the scientific method