<P> Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug . In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss . The drug had previously been used off - label for this purpose . Topiramate was originally produced by Ortho - McNeil Neurologics and Noramco, Inc., both divisions of the Johnson & Johnson Corporation . This medication was discovered in 1979 by Bruce E. Maryanoff and Joseph F. Gardocki during their research work at McNeil Pharmaceuticals . </P> <P> Topiramate came into commercial use in 1996 . Generic versions are available in Canada and these were approved by the FDA in September 2006 . Mylan Pharmaceuticals was granted final approval for generic topiramate by the FDA for sale in the United States . The last patent for topiramate in the U.S. was for use in children and expired on February 28, 2009 . </P> <P> Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant . In children, it is indicated for the treatment of Lennox - Gastaut syndrome, a disorder that causes seizures and developmental delay . It is also Food and Drug Administration (FDA) approved for, and most frequently prescribed for, the prevention of migraines . The drug is also used to treat migraines due to the effect it has on the blood vessels in the brain . It has been found to be increasingly effective for migraine sufferers with limited side effects . </P> <Table> <Tr> <Td> </Td> <Td> This article needs more medical references for verification or relies too heavily on primary sources . Please review the contents of the article and add the appropriate references if you can . Unsourced or poorly sourced material may be challenged and removed . (April 2016) </Td> <Td> </Td> </Tr> </Table>

Topiramate (topamax trokendi) is used to treat which of the following diseases