<Li> Sodium oxybate - benzodiazepines enhance effects of sodium oxybate (avoid concomitant use) </Li> <P> Chlordiazepoxide acts on benzodiazepine allosteric sites that are part of the GABA receptor / ion - channel complex and this results in an increased binding of the inhibitory neurotransmitter GABA to the GABA receptor thereby producing inhibitory effects on the central nervous system and body similar to the effects of other benzodiazepines . Chlordiazepoxide is anticonvulsant . There is preferential storage of chlordiazepoxide in some organs including the heart of the neonate . Absorption by any administered route and the risk of accumulation is significantly increased in the neonate . The withdrawal of chlordiazepoxide during pregnancy and breast feeding is recommended, as chlordiazepoxide rapidly crosses the placenta and also is excreted in breast milk . Chlordiazepoxide also decreases prolactin release in rats . Benzodiazepines act via micromolar benzodiazepine binding sites as Ca2+ channel blockers and significantly inhibit depolarization - sensitive Calcium uptake in animal nerve terminal preparations . Chlordiazepoxide inhibits acetylcholine release in mouse hippocampal synaptosomes in vivo . This has been found by measuring sodium - dependent high affinity choline uptake in vitro after pretreatment of the mice in vivo with chlordiazepoxide . This may play a role in chlordiazepoxide's anticonvulsant properties . </P> <P> Chlordiazepoxide is a long - acting benzodiazepine drug . The half - life of Chlordiazepoxide is 5--30 hours but has an active benzodiazepine metabolite (desmethyldiazepam), which has a half - life of 36--200 hours . The half - life of chlordiazepoxide increases significantly in the elderly, which may result in prolonged action as well as accumulation of the drug during repeated administration . Delayed body clearance of the long half - life active metabolite also occurs in those over 60 years of age, which further prolongs the effects of the drugs with additional accumulation after repeated dosing . </P> <P> Chlordiazepoxide (initially called methaminodiazepoxide) was the first benzodiazepine to be synthesised in the mid-1950s . Chlordiazepoxide was synthesised from work on a chemical dye, quinazolone - 3 - oxides . It was discovered by accident when in 1957 tests revealed that the compound had hypnotic, anxiolytic and muscle relaxant effects . Three years later chlordiazepoxide was marketed as a therapeutic benzodiazepine medication under the brand name Librium . Following chlordiazepoxide, in 1963 diazepam hit the market under the brand name Valium - and was followed by many further benzodiazepine compounds over the subsequent years and decades . </P>

How long do the effects of chlordiazepoxide last
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