<Li> The inflammasome during pyroptosis </Li> <P> Once appropriately dimerised, the Caspases cleaves at inter domain linker regions, forming a large and small subunit . This cleavage allows the active - site loops to take up a conformation favourable for enzymatic activity . </P> <P> Cleavage of Initiator and Executioner caspases occur by different methods outlined in the table below . </P> <Ul> <Li> Initiator caspases auto - proteolytically cleave whereas Executioner caspases are cleaved by initiator caspases . This hierarchy allows an amplifying chain reaction or cascade for degrading cellular components, during controlled cell death . </Li> </Ul>

Activation of initiator pro-caspases 8 9 and 10 requires