<P> Input of water is regulated mainly through ingested fluids, which, in turn, depends on thirst . An insufficiency of water results in an increased osmolarity in the extracellular fluid . This is sensed by osmoreceptors in the organum vasculosum of the lamina terminalis, which trigger thirst . Thirst can to some degree be voluntarily resisted, as during fluid restriction . </P> <P> The human kidneys will normally adjust to varying levels of water intake . The kidneys will require time to adjust to the new water intake level . This can cause someone who drinks a lot of water to become dehydrated more easily than someone who routinely drinks less . </P> <Ul> <Li> The majority of fluid output occurs via the urine, approximately 1500 ml / day (approx 1.59 qt / day) in the normal adult resting state . </Li> <Li> Some fluid is lost through perspiration (part of the body's temperature control mechanism) and as water vapor in exhaled air . These are termed "insensible fluid losses" as they cannot be easily measured . Some sources say insensible losses account for 500 to 650 ml / day (0.5 to 0.6 qt .) of water in adults, while other sources put the minimum value at 800 ml (0.8 qt .). In children, one calculation used for insensible fluid loss is 400 ml / m body surface area . </Li> <Li> In addition, an adult loses approximately 100 ml / day of fluid through feces . </Li> <Li> For females, an additional 50 ml / day is lost through vaginal secretions . </Li> </Ul> <Li> The majority of fluid output occurs via the urine, approximately 1500 ml / day (approx 1.59 qt / day) in the normal adult resting state . </Li>

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