<Li> Hemiballismus, spontaneous flinging limb movements due to contra - lateral subthalamic nucleus damage </Li> <P> The most common adverse reactions, which have occurred in at least 10% of subjects in studies and at least 5% greater than in subjects who received placebo, have been: sedation or somnolence, fatigue, insomnia, depression, suicidal thoughts, akathisia, anxiety and nausea . </P> <P> There is a boxed warning associated with the use of tetrabenazine: </P> <Ul> <Li> Increases the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease </Li> <Li> Balance risks of depression and suicidality with the clinical need for control of chorea when considering the use of tetrabenazine </Li> <Li> Monitor patients for emergence or worsening of depression, suicidality or unusual changes in behavior </Li> <Li> Inform patients, caregivers and families of the risk of depression and suicidality and instruct to report behaviours of concern promptly to the treating physician </Li> <Li> Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation </Li> <Li> Tetrabenazine is contraindicated in patients who are actively suicidal and in patients with untreated or inadequately treated depression </Li> </Ul>

Tetrabenazine for the treatment of chorea and other hyperkinetic movement disorders