<Tr> <Th> Followed by </Th> <Td> Pinky, Elmyra & the Brain </Td> </Tr> <P> Pinky and the Brain is an American animated television series . It was the first animated television series to be presented in Dolby Surround and the fourth collaboration of Steven Spielberg with his production company, Amblin Television, and produced by Warner Bros. Animation . The characters first appeared in 1993 as a recurring segment on Animaniacs . It was later picked up as a series due to its popularity, with 65 episodes produced . Later, they appeared in the series Steven Spielberg Presents Pinky, Elmyra & the Brain . </P> <P> Pinky and Brain are genetically enhanced laboratory mice who reside in a cage in the Acme Labs research facility . Brain is self - centered and scheming; Pinky is good - natured but feebleminded . In each episode, Brain devises a new plan to take over the world which ultimately ends in failure: usually due to Pinky's idiocy, the impossibility of Brain's plan, Brain's own arrogance, or just circumstances beyond their control . In common with many other Animaniacs shorts, many episodes are in some way a parody of something else, usually a film or novel . </P> <P> Many of the Pinky and the Brain episodes occur in the 1990s at Acme Labs, located in some large American city underneath a suspension bridge . Several episodes take place in historical times, with Pinky and the Brain in the laboratory of some scientifically - minded person, including Merlin, H.G. Wells, and Ivan Pavlov . There is very little continuity between episodes outside of the common fixtures of the mice, though some plans for world domination from early episodes are subsequently referred to in later seasons (for example, Brain's "human suit" used in "Win Big" reappears when Brain faces his rival Snowball in "Snowball"). </P>

Mouse who wants to take over the world