<Li> Missense mutations or nonsynonymous mutations are types of point mutations where a single nucleotide is changed to cause substitution of a different amino acid . This in turn can render the resulting protein nonfunctional . Such mutations are responsible for diseases such as Epidermolysis bullosa, sickle - cell disease, and SOD1 - mediated ALS . </Li> <Li> A neutral mutation is a mutation that occurs in an amino acid codon that results in the use of a different, but chemically similar, amino acid . The similarity between the two is enough that little or no change is often rendered in the protein . For example, a change from AAA to AGA will encode arginine, a chemically similar molecule to the intended lysine . </Li> <Li> Silent mutations are mutations that do not result in a change to the amino acid sequence of a protein but do change the nucleotide sequence, unless the changed amino acid is sufficiently similar to the original . They may occur in a region that does not code for a protein, or they may occur within a codon in a manner that does not alter the final amino acid sequence . Silent mutations are also called silent substitutions, since they are not palpable changes as the changes in phenotype . The phrase silent mutation is often used interchangeably with the phrase synonymous mutation; however, synonymous mutations are a subcategory of the former, occurring only within exons (and necessarily exactly preserving the amino acid sequence of the protein). Synonymous mutations occur due to the degenerate nature of the genetic code . There can also be silent mutations in nucleotides outside of the coding regions, such as the introns, because the exact nucleotide sequence is not as crucial as it is in the coding regions . </Li> <P> In multicellular organisms with dedicated reproductive cells, mutations can be subdivided into germline mutations, which can be passed on to descendants through their reproductive cells, and somatic mutations (also called acquired mutations), which involve cells outside the dedicated reproductive group and which are not usually transmitted to descendants . </P>

Name the type of mutation that does not effect protein synthesis