<Tr> <Td> Zone of ossification </Td> <Td> Osteoclasts and osteoblasts from the diaphyseal side break down the calcified cartilage and replace with mineralized bone tissue . </Td> </Tr> <P> A mnemonic for remembering the names of the epiphyseal plate growth zones is "Real People Have Career Options," standing for: Resting zone, Proliferative zone, Hypertrophic cartilage zone, Calcified cartilage zone, Ossification zone . The growth plate is clinically relevant in that it is often the primary site for infection, metastasis, fractures and the effects of endocrine bone disorders . </P> <P> Defects in the development and continued division of epiphyseal plates can lead to growth disorders . The most common defect is achondroplasia, where there is a defect in cartilage formation . Achondroplasia is the most common cause of dwarfism . </P> <P> Salter--Harris fractures are fractures involving epiphyseal plates and hence tend to interfere with growth, height or physiologic functions . </P>

Replacement of cartilage in the growth plate with bone tissue