<Li> Rainn Wilson as Gargamel, an evil wizard who seeks to find the Smurfs and destroy them . </Li> <Li> Mandy Patinkin as Papa Smurf, the fatherly Smurf leader of Smurf Village and Smurf Willow's former arch - rival . Patinkin also narrates the film . </Li> <Li> Joe Manganiello as Hefty Smurf, a strong Smurf who has a crush on Smurfette . </Li> <Li> Jack McBrayer as Clumsy Smurf, an accident - prone Smurf . </Li>

Who plays hefty in smurfs the lost village