<Ul> <Li> Oprah Winfrey as Mrs. Which </Li> <Li> Reese Witherspoon as Mrs. Whatsit </Li> <Li> Mindy Kaling as Mrs. Who </Li> <Li> Storm Reid as Meg Murry, a gifted young girl </Li> <Li> Levi Miller as Calvin O'Keefe, Meg's classmate and friend </Li> <Li> Deric McCabe as Charles Wallace Murry, Meg's prodigious adoptive 6 - year - old brother </Li> <Li> Chris Pine as Dr. Alexander Murry, Meg and Charles Wallace's long - lost father </Li> <Li> Gugu Mbatha - Raw as Dr. Kate Murry, Meg and Charles Wallace's mother </Li> <Li> Zach Galifianakis as The Happy Medium </Li> <Li> Michael Peña as Red <Ul> <Li> David Oyelowo as the IT, Red's true diabolical form </Li> </Ul> </Li> <Li> André Holland as Principal James Jenkins </Li> <Li> Rowan Blanchard as Veronica Kiley </Li> <Li> Bellamy Young as Camazotz Woman </Li> <Li> Conrad Roberts as Elegant Man </Li> <Li> Yvette Cason as a teacher </Li> <Li> Will McCormack as another teacher </Li> <Li> Daniel MacPherson as Calvin's father </Li> </Ul> <Li> Oprah Winfrey as Mrs. Which </Li> <Li> Reese Witherspoon as Mrs. Whatsit </Li> <Li> Mindy Kaling as Mrs. Who </Li>

Who plays mrs. whatsit in a wrinkle in time