<Tr> <Td> ← Previous "Sanctuary" </Td> <Td> Next → "With You I'm Born Again" </Td> </Tr> <Tr> <Td_colspan="2"> Grey's Anatomy (season 6) List of Grey's Anatomy episodes </Td> </Tr> <P> "Death and All His Friends" is the season finale of the sixth season of the American television medical drama Grey's Anatomy, and the show's 126th episode overall . It was written by Shonda Rhimes and directed by Rob Corn . The episode was originally broadcast on the American Broadcasting Company (ABC) in the United States on May 20, 2010 . The episode was the second part of the two - hour season six finale, the first being Sanctuary, and took place at the fictional Seattle Grace Hospital . The original episode broadcast in the United States had an audience of 16.13 million viewers and opened up to universal acclaim . The episode centers a shooting spree at the hospital by a former patient's husband Gary Clark (Michael O'Neill). The episode marked the last appearances for Nora Zehetner and Robert Baker as Dr. Reed Adamson and Dr. Charles Percy respectively as both the characters were killed in the shooting . </P> <P> In the episode Cristina Yang (Sandra Oh) and Jackson Avery (Jesse Williams) try to save the life of Chief Derek Shepherd (Patrick Dempsey) who was shot by Gary Clark in front of Meredith Grey (Ellen Pompeo) as she waits outside the OR with April Kepner (Sarah Drew). Miranda Bailey (Chandra Wilson) tries to save Charles along with her patient Mary Portman (Mandy Moore), while Richard Webber (James Pickens, Jr .) tries to get into the hospital . Callie Torres (Sara Ramirez) and Arizona Robbins (Jessica Capshaw) are stuck on a floor with all the younger patients of the hospital, Mark Sloan (Eric Dane) and Lexie Grey (Chyler Leigh) try to save the life of Alex Karev (Justin Chambers) who was shot as well and Owen Hunt (Kevin McKidd) and Teddy Altman (Kim Raver) try to get their patient to safety . </P>

Who died in season 6 of grey's anatomy