<P> Descriptions of these can be found at the FDA's web site . </P> <Ul> <Li> Durham - Humphrey Amendment, Public Law 82 - 215 (October 26, 1951) created prescription - only status for some drugs </Li> <Li> Drug Efficacy Amendment ("Kefauver Harris Amendment") PL 87 - 781 (October 10, 1962) </Li> <Li> Vitamin - Mineral Amendment ("Proxmire Amendment") (April 22, 1976) prohibited the FDA from establishing standards to limit the potency of vitamins and minerals in food supplements or regulating them as drugs based solely on their potency . </Li> <Li> Medical Device Amendments of 1976 PL 94 - 295 (May 28, 1976) </Li> <Li> Infant Formula Act of 1980, PL 96 - 359 (October 26, 1980) </Li> <Li> Orphan Drug Act, PL 97 - 414 (January 4, 1983) </Li> <Li> Drug Price Competition and Patent Term Restoration Act of 1984, PL 98 - 417 (aka Hatch - Waxman) (September 24, 1984) </Li> <Li> Prescription Drug Marketing Act of 1987, PL 100 - 293 (August 18, 1988) </Li> <Li> Generic Animal Drug and Patent Term Restoration Act of 1988, PL 100 - 670 (November 16, 1988) </Li> <Li> Nutrition Labeling and Education Act of 1990, PL 101 - 535 (November 8, 1990) </Li> <Li> Safe Medical Device Amendments of 1990, PL 101 - 629 (November 28, 1990) </Li> <Li> Medical Device Amendments of 1992, PL 102 - 300 (June 16, 1992) </Li> <Li> Prescription Drug User Fee Act (PDUFA) of 1992, PL 102 - 571 (October 29, 1992) </Li> <Li> Animal Medicinal Drug Use Clarification Act (AMDUCA) of 1994, PL 103 - 396 (October 22, 1994) </Li> <Li> Dietary Supplement Health And Education Act of 1994, PL 103 - 417 (October 25, 1994) </Li> <Li> Food Quality Protection Act of 1996, PL 104 - 170 (August 3, 1996) </Li> <Li> Animal Drug Availability Act of 1996, PL 104 - 250 (October 9, 1996) </Li> <Li> Best Pharmaceuticals for Children Act, PL 107 - 109 (January 4, 2002) </Li> <Li> Medical Device User Fee and Modernization Act (MDUFMA) of 2002, PL 107 - 250 (October 26, 2002) </Li> <Li> Animal Drug User Fee Act of 2003, PL 108 - 130 (February 20, 2003) </Li> <Li> Pediatric Research Equity Act of 2003, PL 108 - 155 (December 3, 2003) </Li> <Li> Minor Use and Minor Species Animal Health Act of 2004 </Li> <Li> Food Allergen Labeling and Consumer Protection Act of 2004, PL 108 - 282 (August 2, 2004) </Li> <Li> FDA Food Safety Modernization Act (January 4, 2011) </Li> <Li> Generic Drug User Fee Amendment of 2012 </Li> </Ul> <Li> Durham - Humphrey Amendment, Public Law 82 - 215 (October 26, 1951) created prescription - only status for some drugs </Li> <Li> Drug Efficacy Amendment ("Kefauver Harris Amendment") PL 87 - 781 (October 10, 1962) </Li>

Prohibited by the food drug and cosmetic act (fdca) with regard to food