<Tr> <Td_colspan="2"> List of Agents of S.H.I.E.L.D. episodes </Td> </Tr> <P> The fifth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement, and Logistics Division), revolves around the character of Phil Coulson and other S.H.I.E.L.D. agents and allies as they try to save humanity while in deep space . It is set in the Marvel Cinematic Universe (MCU), sharing continuity with the films of the franchise . The season is produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners . </P> <P> The season was ordered in May 2017 . Alongside Clark Gregg, who reprises his role as Coulson from the film series, principal cast members Ming - Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, and Henry Simmons return from previous seasons, while Natalia Cordova - Buckley is promoted to the principal cast after appearing in a recurring role since season three . </P> <P> The fifth season is set to begin airing on December 1, 2017, after Marvel's Inhumans has finished airing its episodes, and run for 22 episodes . </P>

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