<Tr> <Td> </Td> <Td> This article or section is currently undergoing a major edit by the Guild of Copy Editors . As a courtesy, please do not edit this page while this message is displayed . The copy editor who added this notice is listed in the page history . This page was last revised at 10: 15, 15 September 2017 (UTC) (0 seconds ago) by BroVic (talk contribs) (Click here to refresh this time calculation .). If you have any questions or concerns, please direct them to the Guild of Copy Editors' talk page . Thank you for your patience . </Td> </Tr> <P> The germ theory of disease states that many diseases are caused by microorganisms . These small organisms, too small to see without magnification, invade humans, animals, and other living hosts . Their growth and reproduction within their hosts can cause a disease . "Germ" may refer to not just a bacterium but to any type of microorganisms, especially one which causes disease, such as protista, fungi, virus, prion, or viroid . Microorganisms that cause disease are called pathogens, and the diseases they cause are called infectious diseases . Even when a pathogen is the principal cause of a disease, environmental and hereditary factors often influence the severity of the disease, and whether a potential host individual becomes infected when exposed to the pathogen . </P> <P> The germ theory was proposed by Girolamo Fracastoro in 1546, and expanded upon by Marcus von Plenciz in 1762 . Such views were held in disdain, however, and Galen's miasma theory remained dominant among scientists and doctors . The nature of this doctrine prevented them from understanding how diseases actually progressed, with predictable consequences . By the early nineteenth century, smallpox vaccination was commonplace in Europe, though doctors were unaware of how it worked or how to extend the principle to other diseases . Similar treatments had been prevalent in India from just before 1000 A.D. A transitional period began in the late 1850s as the work of Louis Pasteur and Robert Koch provided convincing evidence; by 1880, the miasma theory was struggling to compete with the germ theory of disease . Eventually, a "golden era" of bacteriology ensued, during which the theory quickly led to the identification of the actual organisms that cause many diseases . Viruses were discovered in the 1890s . </P> <P> The miasma theory of disease transmission held that diseases such as cholera, chlamydia, or the Black Death were caused by a miasma (μίασμα, Ancient Greek: "pollution"), a noxious form of "bad air". The theory held that the origin of these epidemic diseases was a miasma, emanating from rotting organic matter . Miasma was considered to be a poisonous vapor or mist filled with particles from decomposed matter (miasmata) that caused illnesses . The miasmatic position was that diseases were the product of environmental factors such as contaminated water, foul air, and poor hygienic conditions . Such infection was not passed between individuals but would affect individuals within the locale that gave rise to such vapors . It was identifiable by its foul smell . </P>

Who was responsible for establishing the idea that microorganisms play a role in disease