<Tr> <Td> ← Previous "Deterioration of the Fight or Flight Response" </Td> <Td> Next → "Time Has Come Today" </Td> </Tr> <Tr> <Td_colspan="2"> Grey's Anatomy (season 2) List of Grey's Anatomy episodes </Td> </Tr> <P> "Losing My Religion" is the twenty - seventh and final episode of the second season of the American television medical drama Grey's Anatomy, and the show's 36th episode overall . Written by Shonda Rhimes and directed by Mark Tinker, the episode was originally broadcast with "Deterioration of the Fight or Flight Response", in a two - hour season finale event on the American Broadcasting Company (ABC) in the United States on May 15, 2006 . Grey's Anatomy centers around a group of young doctors in training . In this episode, Dr. Izzie Stevens (Katherine Heigl) and her fellow interns have to plan a prom for Dr. Richard Webber's (James Pickens, Jr .) niece Camille Travis (Tessa Thompson). Further storylines include Dr. Preston Burke (Isaiah Washington) recovering from his gunshot wound and Denny Duquette's (Jeffrey Dean Morgan) death following his seemingly successful heart transplant surgery . </P> <P> The episode marked Sara Ramirez's (Dr. Callie Torres) final appearance with recurring billing, as she would be upgraded to a series regular in season three . Morgan, Ramirez, Thompson, Brooke Smith, Sarah Utterback, Loretta Devine, and Chris O'Donnell reprised their roles as guest stars, while Hallee Hirsh and Tiffany Hines made their first and only appearances . The episode received mixed to negative reviews from television critics, who disapproved of the storyline involving Grey and Shepherd and the show's lack of repercussions for the interns, but lauded Dr. Cristina Yang's (Sandra Oh) storyline along with Heigl's performance . "Losing My Religion" was also included in several "best episodes" lists . Upon its initial airing, the episode was viewed 22.50 million Americans, garnered an 8.0 / 22 Nielsen rating / share in the 18--49 demographic, ranking fifth for the week in terms of viewership, and registering as the week's second highest - rated drama . </P>

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