<Li> Kevin James as Frank / Frankenstein, Eunice's husband and one of Dracula's best friends who acts as an uncle to Mavis and mostly hangs out with Murray . </Li> <Li> Fran Drescher as Eunice, Frankenstein's wife and Wanda's best friend . </Li> <Li> Steve Buscemi as Wayne, a male werewolf who is also one of Dracula's best friends and Wanda's husband . </Li> <Li> Molly Shannon as Wanda, a female werewolf, Wayne's heavily - pregnant wife and Eunice's best friend . </Li>

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