<Table> <Tr> <Td> </Td> <Td> This article includes a list of references, but its sources remain unclear because it has insufficient inline citations . Please help to improve this article by introducing more precise citations . (May 2011) (Learn how and when to remove this template message) </Td> </Tr> </Table> <Tr> <Td> </Td> <Td> This article includes a list of references, but its sources remain unclear because it has insufficient inline citations . Please help to improve this article by introducing more precise citations . (May 2011) (Learn how and when to remove this template message) </Td> </Tr> <P> The centromere is the specialized DNA sequence of a chromosome that links a pair of sister chromatids (a dyad). During mitosis, spindle fibers attach to the centromere via the kinetochore . Centromeres were first thought to be genetic loci that direct the behavior of chromosomes . </P> <P> The physical role of the centromere is to act as the site of assembly of the kinetochores--a highly complex multiprotein structure that is responsible for the actual events of chromosome segregation--i.e. binding microtubules and signalling to the cell cycle machinery when all chromosomes have adopted correct attachments to the spindle, so that it is safe for cell division to proceed to completion and for cells to enter anaphase . </P>

What is the major constituent of a chromosome