<P> A topical medication is a medication that is applied to a particular place on or in the body . Most often topical administration means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments . Many topical medications are epicutaneous, meaning that they are applied directly to the skin . Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth . The word topical derives from Greek τοπικός topikos, "of a place". </P> <P> The definition of the topical route of administration sometimes states that both the application location and the pharmacodynamic effect thereof is local . </P> <P> In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect . By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic distribution . Such medications are generally hydrophobic chemicals, such as steroid hormones . Specific types include transdermal patches have become a popular means of administering some drugs for birth control, hormone replacement therapy, and prevention of motion sickness . One example of an antibiotic that may be applied topically is chloramphenicol . </P> <P> If defined strictly as having local effect, the topical route of administration can also include enteral administration of medications that are poorly absorbable by the gastrointestinal tract . One poorly absorbable antibiotic is vancomycin, which is recommended by mouth as a treatment for severe Clostridium difficile colitis . </P>

Method of administering a drug by topical friction over skin is called