<Tr> <Th> Box office </Th> <Td> $61.4 million </Td> </Tr> <P> Isle of Dogs (犬 ヶ 島, Inugashima) is a 2018 stop - motion animated film written, produced and directed by Wes Anderson . Set in a dystopian near - future Japan, the film follows a group of dogs who helps a young boy searching for his dog after the whole species is banished to an island after a canine - flu outbreak . The ensemble voice cast includes Bryan Cranston, Edward Norton, Bill Murray, Jeff Goldblum, Bob Balaban, Greta Gerwig, Frances McDormand, Courtney B. Vance, Fisher Stevens, Harvey Keitel, Liev Schreiber, Scarlett Johansson, Tilda Swinton, F. Murray Abraham, Frank Wood, Kunichi Nomura and Yoko Ono . </P> <P> A US - German co-production, Isle of Dogs was produced by Indian Paintbrush and Anderson's own production company, American Empirical Pictures . The film opened the 68th Berlin International Film Festival, where Anderson was awarded the Silver Bear for Best Director . It was given a limited release in the United States on March 23, 2018, by Fox Searchlight Pictures, and went on wide release on April 13 . It has grossed $61 million worldwide, and received praise for its animation, story, and deadpan humor; some critics, however, have accused it of cultural appropriation . </P> <P> In a dystopian near - future Japan, a dog - flu virus spreads throughout the canine population . Though one scientist, Professor Watanabe, is close to finding a cure, the authoritarian mayor of Megasaki City, Kobayashi, signs a decree banishing all dogs to Trash Island . The first exile is Spots, who belonged to Atari Kobayashi, the orphaned nephew and ward of the mayor . </P>

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