<Tr> <Th_colspan="2"> Pharmacokinetic data </Th> </Tr> <Tr> <Th> Bioavailability </Th> <Td> 26--50% </Td> </Tr> <Tr> <Th> Protein binding </Th> <Td> 85--90% </Td> </Tr> <Tr> <Th> Metabolism </Th> <Td> Liver </Td> </Tr>

Where in the body do direct-acting vasodilators act to decrease blood pressure